rs17629798

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0174 (5237/29950,GnomAD)
C=0168 (4894/29118,TOPMED)
C=0167 (834/5008,1000G)
C=0202 (779/3854,ALSPAC)
C=0227 (840/3708,TWINSUK)
chr17:35219913 (GRCh38.p7) (17q12)
ND
GWASdb2
1   publication(s)
See rs on genome
22 Enhancers around
8 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 17NC_000017.11:g.35219913T>C
GRCh37.p13 chr 17NC_000017.10:g.33546932T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.906C=0.094
1000GenomesAmericanSub694T=0.690C=0.310
1000GenomesEast AsianSub1008T=0.891C=0.109
1000GenomesEuropeSub1006T=0.820C=0.180
1000GenomesGlobalStudy-wide5008T=0.833C=0.167
1000GenomesSouth AsianSub978T=0.790C=0.210
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.798C=0.202
The Genome Aggregation DatabaseAfricanSub8720T=0.888C=0.112
The Genome Aggregation DatabaseAmericanSub836T=0.740C=0.260
The Genome Aggregation DatabaseEast AsianSub1614T=0.898C=0.102
The Genome Aggregation DatabaseEuropeSub18478T=0.792C=0.207
The Genome Aggregation DatabaseGlobalStudy-wide29950T=0.825C=0.174
The Genome Aggregation DatabaseOtherSub302T=0.860C=0.140
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.831C=0.168
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.773C=0.227
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs176297980.000667nicotine dependence17158188

eQTL of rs17629798 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr17:33546932SLFN5ENSG00000166750.5T>C1.5951e-10-23123Hypothalamus
Chr17:33546932SLFN5ENSG00000166750.5T>C6.3373e-8-23123Hippocampus

meQTL of rs17629798 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr173358360233583988E06936670
chr173357961533579659E07132683
chr173357972433580014E07132792
chr173358026433580325E07133332
chr173358050133580567E07133569
chr173358076933580905E07133837
chr173358094733581012E07134015
chr173358112333581177E07134191
chr173358119733581779E07134265
chr173358227833582318E07135346
chr173358233533582402E07135403
chr173358246733582651E07135535
chr173358412433584705E07137192
chr173359122433591264E07144292
chr173359193033591996E07144998
chr173359204433592112E07145112
chr173359228433592642E07145352
chr173359265433593107E07145722
chr173359327133593339E07146339
chr173359337333593423E07146441
chr173358233533582402E08135403
chr173358246733582651E08135535



Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr173356882133572764E06721889
chr173356882133572764E06821889
chr173356882133572764E06921889
chr173356882133572764E07121889
chr173356882133572764E07221889
chr173356882133572764E07321889
chr173356882133572764E07421889
chr173356882133572764E08221889