rs17637986

Homo sapiens
T>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0062 (1868/29952,GnomAD)
G=0049 (1426/29118,TOPMED)
G=0095 (475/5008,1000G)
G=0085 (329/3854,ALSPAC)
G=0082 (304/3708,TWINSUK)
chr8:6776181 (GRCh38.p7) (8p23.1)
AD
GWASdb2
1   publication(s)
See rs on genome
151 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.6776181T>G
GRCh37.p13 chr 8NC_000008.10:g.6633702T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.977G=0.023
1000GenomesAmericanSub694T=0.950G=0.050
1000GenomesEast AsianSub1008T=0.923G=0.077
1000GenomesEuropeSub1006T=0.908G=0.092
1000GenomesGlobalStudy-wide5008T=0.905G=0.095
1000GenomesSouth AsianSub978T=0.760G=0.240
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.915G=0.085
The Genome Aggregation DatabaseAfricanSub8726T=0.969G=0.031
The Genome Aggregation DatabaseAmericanSub838T=0.950G=0.050
The Genome Aggregation DatabaseEast AsianSub1622T=0.909G=0.091
The Genome Aggregation DatabaseEuropeSub18464T=0.925G=0.074
The Genome Aggregation DatabaseGlobalStudy-wide29952T=0.937G=0.062
The Genome Aggregation DatabaseOtherSub302T=0.890G=0.110
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.951G=0.049
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.918G=0.082
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs176379860.0000517alcoholismpha002893
rs176379860.000052alcohol dependence20201924
rs176379860.0000545alcoholismpha002892
rs176379860.000055alcohol dependence(early age of onset)20201924

eQTL of rs17637986 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs17637986 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr865911596591295E067-42407
chr866021546602208E067-31494
chr866023376602502E067-31200
chr866025816602631E067-31071
chr866307976631081E067-2621
chr866311196631474E067-2228
chr866320616632111E067-1591
chr866321546632194E067-1508
chr866321956632300E067-1402
chr866325886632650E067-1052
chr866326786632807E067-895
chr865900786590258E068-43444
chr865902836590344E068-43358
chr865903556590577E068-43125
chr865906936591135E068-42567
chr865911596591295E068-42407
chr865939536594929E068-38773
chr866018176601934E068-31768
chr866032616603388E068-30314
chr866332216633413E068-289
chr866334806633811E0680
chr866338776633957E068175
chr866451976645852E06811495
chr866579706659071E06824268
chr865900786590258E069-43444
chr865902836590344E069-43358
chr865903556590577E069-43125
chr865906936591135E069-42567
chr865911596591295E069-42407
chr866021546602208E069-31494
chr866023376602502E069-31200
chr866325886632650E069-1052
chr866326786632807E069-895
chr866330056633106E069-596
chr866332216633413E069-289
chr866334806633811E0690
chr866451976645852E06911495
chr866459586646009E06912256
chr866510876651154E06917385
chr865903556590577E070-43125
chr865906936591135E070-42567
chr866073716607949E070-25753
chr866451976645852E07011495
chr866500716650131E07016369
chr866501336650183E07016431
chr866504016650495E07016699
chr866505116650847E07016809
chr865839706584045E071-49657
chr865841936584377E071-49325
chr865892916589699E071-44003
chr865898036589925E071-43777
chr865906936591135E071-42567
chr865911596591295E071-42407
chr866018176601934E071-31768
chr866021546602208E071-31494
chr866023376602502E071-31200
chr866032616603388E071-30314
chr866311196631474E071-2228
chr866314766631855E071-1847
chr866318566632013E071-1689
chr866320616632111E071-1591
chr866321546632194E071-1508
chr866321956632300E071-1402
chr866330056633106E071-596
chr866332216633413E071-289
chr866334806633811E0710
chr866367466637848E0713044
chr866451976645852E07111495
chr866516436651683E07117941
chr866517336651787E07118031
chr866520616652245E07118359
chr865867106587283E072-46419
chr865873576587558E072-46144
chr865903556590577E072-43125
chr866073716607949E072-25753
chr866210056621302E072-12400
chr866314766631855E072-1847
chr866330056633106E072-596
chr866332216633413E072-289
chr866334806633811E0720
chr866451976645852E07211495
chr866579706659071E07224268
chr865906936591135E073-42567
chr865911596591295E073-42407
chr866018176601934E073-31768
chr866021546602208E073-31494
chr866023376602502E073-31200
chr866073716607949E073-25753
chr866318566632013E073-1689
chr866320616632111E073-1591
chr866321546632194E073-1508
chr866321956632300E073-1402
chr866451976645852E07311495
chr866510876651154E07317385
chr866516436651683E07317941
chr866517336651787E07318031
chr866520616652245E07318359
chr866523736652474E07318671
chr865892916589699E074-44003
chr865898036589925E074-43777
chr865900786590258E074-43444
chr865902836590344E074-43358
chr865903556590577E074-43125
chr865906936591135E074-42567
chr865911596591295E074-42407
chr865939536594929E074-38773
chr866006406600712E074-32990
chr866007356600819E074-32883
chr866008276600923E074-32779
chr866018176601934E074-31768
chr866021546602208E074-31494
chr866032616603388E074-30314
chr866045036604570E074-29132
chr866046396604689E074-29013
chr866047666604926E074-28776
chr866314766631855E074-1847
chr866318566632013E074-1689
chr866320616632111E074-1591
chr866321546632194E074-1508
chr866321956632300E074-1402
chr866325886632650E074-1052
chr866326786632807E074-895
chr866332216633413E074-289
chr866334806633811E0740
chr866338776633957E074175
chr866442316644328E08110529
chr866443846644424E08110682
chr866444966644563E08110794
chr866449356644985E08111233
chr866451976645852E08111495
chr866459586646009E08112256
chr866504016650495E08116699
chr866505116650847E08116809
chr866579706659071E08124268
chr866745106674581E08140808
chr866747386674785E08141036
chr866748186674910E08141116
chr866749766675026E08141274
chr866753326675513E08141630
chr865906936591135E082-42567
chr866318566632013E082-1689
chr866320616632111E082-1591
chr866321546632194E082-1508
chr866321956632300E082-1402
chr866442316644328E08210529
chr866443846644424E08210682
chr866444966644563E08210794
chr866745106674581E08240808
chr866747386674785E08241036
chr866748186674910E08241116
chr866749766675026E08241274