rs17718330

Homo sapiens
T>C
GPR176 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0233 (6990/29932,GnomAD)
C=0218 (6353/29118,TOPMED)
C=0137 (687/5008,1000G)
C=0304 (1170/3854,ALSPAC)
C=0302 (1119/3708,TWINSUK)
chr15:39831148 (GRCh38.p7) (15q15.1)
AD
GWASdb2
1   publication(s)
See rs on genome
73 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.39831148T>C
GRCh37.p13 chr 15NC_000015.9:g.40123349T>C

Gene: GPR176, G protein-coupled receptor 176(minus strand)

Molecule type Change Amino acid[Codon] SO Term
GPR176 transcript variant 2NM_001271854.1:c.N/AIntron Variant
GPR176 transcript variant 1NM_007223.2:c.N/AIntron Variant
GPR176 transcript variant 3NM_001271855.1:c.N/AGenic Upstream Transcript Variant
GPR176 transcript variant X2XM_011521167.2:c.N/AIntron Variant
GPR176 transcript variant X1XM_011521168.2:c.N/AIntron Variant
GPR176 transcript variant X3XM_017021873.1:c.N/AIntron Variant
GPR176 transcript variant X4XM_017021874.1:c.N/AIntron Variant
GPR176 transcript variant X5XM_017021875.1:c.N/AIntron Variant
GPR176 transcript variant X7XM_017021876.1:c.N/AIntron Variant
GPR176 transcript variant X8XM_017021877.1:c.N/AIntron Variant
GPR176 transcript variant X8XM_017021878.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.900C=0.100
1000GenomesAmericanSub694T=0.830C=0.170
1000GenomesEast AsianSub1008T=0.994C=0.006
1000GenomesEuropeSub1006T=0.691C=0.309
1000GenomesGlobalStudy-wide5008T=0.863C=0.137
1000GenomesSouth AsianSub978T=0.870C=0.130
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.696C=0.304
The Genome Aggregation DatabaseAfricanSub8718T=0.865C=0.135
The Genome Aggregation DatabaseAmericanSub838T=0.820C=0.180
The Genome Aggregation DatabaseEast AsianSub1604T=0.994C=0.006
The Genome Aggregation DatabaseEuropeSub18470T=0.699C=0.300
The Genome Aggregation DatabaseGlobalStudy-wide29932T=0.766C=0.233
The Genome Aggregation DatabaseOtherSub302T=0.680C=0.320
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.781C=0.218
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.698C=0.302
PMID Title Author Journal
22072270Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms.Wang KSJ Neural Transm (Vienna)

P-Value

SNP ID p-value Traits Study
rs177183305.67E-05alcohol withdrawal symptoms22072270

eQTL of rs17718330 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs17718330 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr154007637640076588E067-46761
chr154007778740077984E067-45365
chr154007807140078179E067-45170
chr154007820440078534E067-44815
chr154007854540079127E067-44222
chr154007637640076588E068-46761
chr154007778740077984E068-45365
chr154007820440078534E068-44815
chr154007854540079127E068-44222
chr154012040840120458E068-2891
chr154012051640120901E068-2448
chr154007807140078179E069-45170
chr154007820440078534E069-44815
chr154007854540079127E069-44222
chr154012040840120458E069-2891
chr154012051640120901E069-2448
chr154007807140078179E070-45170
chr154011231540112475E070-10874
chr154011250840112676E070-10673
chr154012040840120458E070-2891
chr154012051640120901E070-2448
chr154014349840143659E07020149
chr154014370440144287E07020355
chr154014439840144864E07021049
chr154007637640076588E071-46761
chr154007820440078534E071-44815
chr154007854540079127E071-44222
chr154007637640076588E072-46761
chr154007807140078179E072-45170
chr154007820440078534E072-44815
chr154007854540079127E072-44222
chr154012040840120458E072-2891
chr154012051640120901E072-2448
chr154007750040077608E073-45741
chr154007778740077984E073-45365
chr154007807140078179E073-45170
chr154007820440078534E073-44815
chr154007854540079127E073-44222
chr154007637640076588E074-46761
chr154007820440078534E074-44815
chr154007854540079127E074-44222
chr154007637640076588E081-46761
chr154007661740076735E081-46614
chr154007684540076914E081-46435
chr154007693540077027E081-46322
chr154007706140077111E081-46238
chr154007725840077316E081-46033
chr154007750040077608E081-45741
chr154007778740077984E081-45365
chr154007807140078179E081-45170
chr154007820440078534E081-44815
chr154007854540079127E081-44222
chr154014349840143659E08120149
chr154014370440144287E08120355
chr154014439840144864E08121049
chr154014487940145002E08121530
chr154016201240162098E08138663
chr154016210040162523E08138751
chr154016255740162603E08139208
chr154016284040162890E08139491
chr154016293540163092E08139586
chr154016981840170687E08146469
chr154017074140170876E08147392
chr154017106340171113E08147714
chr154017130440171364E08147955
chr154007807140078179E082-45170
chr154011820340118479E082-4870
chr154012040840120458E082-2891
chr154012051640120901E082-2448
chr154014349840143659E08220149
chr154014370440144287E08220355
chr154014439840144864E08221049
chr154014487940145002E08221530










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr154007385640076375E067-46974
chr154007385640076375E068-46974
chr154007385640076375E069-46974
chr154007385640076375E070-46974
chr154007385640076375E071-46974
chr154007385640076375E072-46974
chr154007385640076375E073-46974
chr154007385640076375E074-46974
chr154007385640076375E081-46974
chr154007385640076375E082-46974