SNP Detail Info-rs17735215

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 11	NC_000011.10:g.84627241T>C
GRCh37.p13 chr 11	NC_000011.9:g.84338284T>C
DLG2 RefSeqGene	NG_021375.1:g.1005031A>G

Gene: DLG2, discs large homolog 2(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
DLG2 transcript variant 1	NM_001142699.1:c.	N/A	Intron Variant
DLG2 transcript variant 6	NM_001300983.1:c.	N/A	Intron Variant
DLG2 transcript variant 2	NM_001364.3:c.	N/A	Intron Variant
DLG2 transcript variant 3	NM_001142700.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant 4	NM_001142702.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant 5	NM_001206769.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X4	XM_011544778.2:c.	N/A	Intron Variant
DLG2 transcript variant X6	XM_011544780.2:c.	N/A	Intron Variant
DLG2 transcript variant X15	XM_011544782.2:c.	N/A	Intron Variant
DLG2 transcript variant X1	XM_017017254.1:c.	N/A	Intron Variant
DLG2 transcript variant X2	XM_017017255.1:c.	N/A	Intron Variant
DLG2 transcript variant X3	XM_017017256.1:c.	N/A	Intron Variant
DLG2 transcript variant X5	XM_017017257.1:c.	N/A	Intron Variant
DLG2 transcript variant X7	XM_017017258.1:c.	N/A	Intron Variant
DLG2 transcript variant X8	XM_017017259.1:c.	N/A	Intron Variant
DLG2 transcript variant X9	XM_017017260.1:c.	N/A	Intron Variant
DLG2 transcript variant X10	XM_017017261.1:c.	N/A	Intron Variant
DLG2 transcript variant X12	XM_017017263.1:c.	N/A	Intron Variant
DLG2 transcript variant X13	XM_017017264.1:c.	N/A	Intron Variant
DLG2 transcript variant X14	XM_017017265.1:c.	N/A	Intron Variant
DLG2 transcript variant X17	XM_017017267.1:c.	N/A	Intron Variant
DLG2 transcript variant X18	XM_017017268.1:c.	N/A	Intron Variant
DLG2 transcript variant X19	XM_017017269.1:c.	N/A	Intron Variant
DLG2 transcript variant X20	XM_017017270.1:c.	N/A	Intron Variant
DLG2 transcript variant X21	XM_017017271.1:c.	N/A	Intron Variant
DLG2 transcript variant X22	XM_017017272.1:c.	N/A	Intron Variant
DLG2 transcript variant X23	XM_017017274.1:c.	N/A	Intron Variant
DLG2 transcript variant X25	XM_017017276.1:c.	N/A	Intron Variant
DLG2 transcript variant X29	XM_017017279.1:c.	N/A	Intron Variant
DLG2 transcript variant X31	XM_017017280.1:c.	N/A	Intron Variant
DLG2 transcript variant X32	XM_017017281.1:c.	N/A	Intron Variant
DLG2 transcript variant X35	XM_017017285.1:c.	N/A	Intron Variant
DLG2 transcript variant X28	XM_005273810.4:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X32	XM_005273811.4:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X36	XM_011544788.2:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X11	XM_017017262.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X16	XM_017017266.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X23	XM_017017273.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X24	XM_017017275.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X26	XM_017017277.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X27	XM_017017278.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X34	XM_017017282.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X33	XM_017017283.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X34	XM_017017284.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X39	XM_017017286.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X38	XM_017017287.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X39	XM_017017288.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X40	XM_017017289.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X41	XM_017017290.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X42	XM_017017291.1:c.	N/A	Genic Upstream Transcript Variant
DLG2 transcript variant X43	XM_017017292.1:c.	N/A	Genic Upstream Transcript Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	T=0.986	C=0.014
1000Genomes	American	Sub	694	T=0.840	C=0.160
1000Genomes	East Asian	Sub	1008	T=0.970	C=0.030
1000Genomes	Europe	Sub	1006	T=0.907	C=0.093
1000Genomes	Global	Study-wide	5008	T=0.931	C=0.069
1000Genomes	South Asian	Sub	978	T=0.910	C=0.090
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	T=0.889	C=0.111
The Genome Aggregation Database	African	Sub	8730	T=0.974	C=0.026
The Genome Aggregation Database	American	Sub	838	T=0.850	C=0.150
The Genome Aggregation Database	East Asian	Sub	1618	T=0.966	C=0.034
The Genome Aggregation Database	Europe	Sub	18498	T=0.892	C=0.107
The Genome Aggregation Database	Global	Study-wide	29986	T=0.918	C=0.081
The Genome Aggregation Database	Other	Sub	302	T=0.850	C=0.150
Trans-Omics for Precision Medicine	Global	Study-wide	29118	T=0.925	C=0.074
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	T=0.887	C=0.113

PMID	Title	Author	Journal
19268276	Genome-wide association study of smoking initiation and current smoking.	Vink JM	Am J Hum Genet

P-Value

SNP ID	p-value	Traits	Study
rs17735215	0.000275	nicotine smoking	19268276

eQTL of rs17735215 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs17735215 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr11	84299052	84299159	E067	-39125
chr11	84299183	84299274	E067	-39010
chr11	84299052	84299159	E068	-39125
chr11	84299183	84299274	E068	-39010
chr11	84301760	84301810	E068	-36474
chr11	84301931	84302049	E068	-36235
chr11	84319053	84319351	E068	-18933
chr11	84386402	84386456	E068	48118
chr11	84386544	84386673	E068	48260
chr11	84319376	84320310	E069	-17974
chr11	84366574	84366624	E070	28290
chr11	84366627	84366724	E070	28343
chr11	84366867	84367254	E070	28583
chr11	84386544	84386673	E072	48260
chr11	84386898	84387015	E072	48614
chr11	84305469	84305521	E081	-32763
chr11	84305789	84306100	E081	-32184
chr11	84306197	84306274	E081	-32010
chr11	84356845	84356958	E081	18561
chr11	84356994	84357044	E081	18710
chr11	84357163	84357286	E081	18879
chr11	84357290	84357462	E081	19006
chr11	84359255	84359305	E081	20971
chr11	84359387	84359516	E081	21103
chr11	84359554	84359801	E081	21270
chr11	84359820	84359954	E081	21536
chr11	84360111	84360265	E081	21827
chr11	84360744	84360944	E081	22460
chr11	84365951	84366001	E081	27667
chr11	84383301	84383377	E081	45017

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr11	84291410	84291858	E068	-46426
chr11	84291410	84291858	E069	-46426
chr11	84291410	84291858	E071	-46426
chr11	84291410	84291858	E072	-46426
chr11	84291410	84291858	E074	-46426

rs17735215

Genomic Coordinates

Gene: DLG2, discs large homolog 2(minus strand)

Population Frequency

P-Value

eQTL of rs17735215 in Brain tissues (GTEx Analysis Release V7)

meQTL of rs17735215 in Fetal Brain

Genomic View

Chromatin Interaction

Enhancer Annotation (GRCh37.p13)

Promoter Annotation (GRCh37.p13)