rs17778162

Homo sapiens
G>A
KSR1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0221 (6633/29916,GnomAD)
A=0211 (6169/29118,TOPMED)
A=0152 (760/5008,1000G)
A=0260 (1001/3854,ALSPAC)
A=0247 (916/3708,TWINSUK)
chr17:27523483 (GRCh38.p7) (17q11.2)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 17NC_000017.11:g.27523483G>A
GRCh37.p13 chr 17NC_000017.10:g.25850509G>A

Gene: KSR1, kinase suppressor of ras 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
KSR1 transcriptNM_014238.1:c.N/AIntron Variant
KSR1 transcript variant X7XM_006722154.3:c.N/AIntron Variant
KSR1 transcript variant X1XM_011525429.2:c.N/AIntron Variant
KSR1 transcript variant X5XM_011525430.2:c.N/AIntron Variant
KSR1 transcript variant X6XM_011525431.2:c.N/AIntron Variant
KSR1 transcript variant X2XM_017025267.1:c.N/AIntron Variant
KSR1 transcript variant X3XM_017025268.1:c.N/AIntron Variant
KSR1 transcript variant X9XM_017025269.1:c.N/AIntron Variant
KSR1 transcript variant X11XM_017025271.1:c.N/AIntron Variant
KSR1 transcript variant X12XM_017025272.1:c.N/AIntron Variant
KSR1 transcript variant X13XM_017025273.1:c.N/AIntron Variant
KSR1 transcript variant X15XM_017025274.1:c.N/AIntron Variant
KSR1 transcript variant X16XM_017025275.1:c.N/AIntron Variant
KSR1 transcript variant X16XM_017025276.1:c.N/AIntron Variant
KSR1 transcript variant X19XM_017025279.1:c.N/AIntron Variant
KSR1 transcript variant X21XM_017025280.1:c.N/AIntron Variant
KSR1 transcript variant X11XM_017025270.1:c.N/AGenic Upstream Transcript Variant
KSR1 transcript variant X17XM_017025277.1:c.N/AGenic Upstream Transcript Variant
KSR1 transcript variant X18XM_017025278.1:c.N/AGenic Upstream Transcript Variant
KSR1 transcript variant X4XR_934587.2:n.N/AIntron Variant
KSR1 transcript variant X8XR_934588.2:n.N/AIntron Variant
KSR1 transcript variant X10XR_934589.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.829A=0.171
1000GenomesAmericanSub694G=0.840A=0.160
1000GenomesEast AsianSub1008G=0.974A=0.026
1000GenomesEuropeSub1006G=0.734A=0.266
1000GenomesGlobalStudy-wide5008G=0.848A=0.152
1000GenomesSouth AsianSub978G=0.870A=0.130
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.740A=0.260
The Genome Aggregation DatabaseAfricanSub8712G=0.817A=0.183
The Genome Aggregation DatabaseAmericanSub836G=0.860A=0.140
The Genome Aggregation DatabaseEast AsianSub1618G=0.973A=0.027
The Genome Aggregation DatabaseEuropeSub18448G=0.740A=0.259
The Genome Aggregation DatabaseGlobalStudy-wide29916G=0.778A=0.221
The Genome Aggregation DatabaseOtherSub302G=0.690A=0.310
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.788A=0.211
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.753A=0.247
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs177781620.000177alcohol dependence21314694

eQTL of rs17778162 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs17778162 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr172580758725807731E067-42778
chr172580780625807868E067-42641
chr172580788925807997E067-42512
chr172581270425812748E067-37761
chr172581314225813341E067-37168
chr172581603625816471E067-34038
chr172581663725816681E067-33828
chr172581676225816821E067-33688
chr172581865425819401E067-31108
chr172581945125819801E067-30708
chr172581983325820179E067-30330
chr172582021425820305E067-30204
chr172582048925820630E067-29879
chr172582064025820717E067-29792
chr172582076525820815E067-29694
chr172582095225822157E067-28352
chr172582226725822356E067-28153
chr172582243925822489E067-28020
chr172582254425822797E067-27712
chr172582282525822868E067-27641
chr172582291525823028E067-27481
chr172582308025824051E067-26458
chr172582417925824247E067-26262
chr172582433325824433E067-26076
chr172582636525826425E067-24084
chr172582658225826782E067-23727
chr172582679325826843E067-23666
chr172582687725826931E067-23578
chr172582707625827148E067-23361
chr172582717525827215E067-23294
chr172582744125827507E067-23002
chr172582792225828074E067-22435
chr172582910425829325E067-21184
chr172582935125829467E067-21042
chr172582949525830212E067-20297
chr172583025225830453E067-20056
chr172583053125830581E067-19928
chr172583063225831031E067-19478
chr172583108625831253E067-19256
chr172583125925831543E067-18966
chr172583161925831980E067-18529
chr172583212825832248E067-18261
chr172583226325832668E067-17841
chr172583786225837917E067-12592
chr172583805525838108E067-12401
chr172583813925838332E067-12177
chr172583835225838515E067-11994
chr172583857125838721E067-11788
chr172583873825838926E067-11583
chr172583896025839156E067-11353
chr172583927525839372E067-11137
chr172583960525839655E067-10854
chr172583969825839809E067-10700
chr172583981425839984E067-10525
chr172584002925840239E067-10270
chr172584048325840533E067-9976
chr172584058825841469E067-9040
chr172584175125842133E067-8376
chr172584221425842289E067-8220
chr172584238125842607E067-7902
chr172584282425843103E067-7406
chr172584311425843465E067-7044
chr172584351325843563E067-6946
chr172584451125844551E067-5958
chr172584457425844672E067-5837
chr172584501825845096E067-5413
chr172584525525845305E067-5204
chr172584571525846061E067-4448
chr172584608925846460E067-4049
chr172584652725846791E067-3718
chr172584680325846856E067-3653
chr172584690225846999E067-3510
chr172584702025847087E067-3422
chr172584709625847146E067-3363
chr172584717725847562E067-2947
chr172584759225847802E067-2707
chr172584783825848207E067-2302
chr172584821525848288E067-2221
chr172584829625848340E067-2169
chr172584843225848589E067-1920
chr172584867525849078E067-1431
chr172584916525849251E067-1258
chr172584936725849594E067-915
chr172585339425853482E0672885
chr172585353725854144E0673028
chr172585439925854453E0673890
chr172585770925860268E0677200
chr172586027325860352E0679764
chr172586076525861038E06710256
chr172586105025861533E06710541
chr172586226125863410E06711752
chr172586342625863619E06712917
chr172586494025864990E06714431
chr172586512925865223E06714620
chr172586532425865403E06714815
chr172586541125865468E06714902
chr172586547725865601E06714968
chr172586564625865840E06715137
chr172586586625866020E06715357
chr172586603325866190E06715524
chr172586621125866319E06715702
chr172586638225866503E06715873
chr172586656425866809E06716055
chr172586689725868325E06716388
chr172586836125868448E06717852
chr172586847725868527E06717968
chr172586988225870240E06719373
chr172587037925870419E06719870
chr172587065425870858E06720145
chr172587598725876371E06725478
chr172587638325876556E06725874
chr172587663425876852E06726125
chr172587777125877987E06727262
chr172587817725878248E06727668
chr172587831625878393E06727807
chr172588614325888184E06735634
chr172589362725894127E06743118
chr172589523925895289E06744730
chr172589533425895426E06744825
chr172589544725895541E06744938
chr172589560925895659E06745100
chr172589574625895837E06745237
chr172589591025896077E06745401
chr172589622825896818E06745719
chr172589687925897754E06746370
chr172589824625899199E06747737
chr172589927925899372E06748770
chr172580179625802020E068-48489
chr172580211925802362E068-48147
chr172580242025802674E068-47835
chr172580280725802918E068-47591
chr172580341125803494E068-47015
chr172580360625803810E068-46699
chr172580410125804152E068-46357
chr172580423725804555E068-45954
chr172580758725807731E068-42778
chr172580780625807868E068-42641
chr172580788925807997E068-42512
chr172581201825812104E068-38405
chr172581222725812312E068-38197
chr172581236325812542E068-37967
chr172581270425812748E068-37761
chr172581280725812902E068-37607
chr172581292125812973E068-37536
chr172581301625813070E068-37439
chr172581314225813341E068-37168
chr172581344325813501E068-37008
chr172581516525815258E068-35251
chr172581535925815590E068-34919
chr172581603625816471E068-34038
chr172581663725816681E068-33828
chr172581676225816821E068-33688
chr172581865425819401E068-31108
chr172581945125819801E068-30708
chr172581983325820179E068-30330
chr172582021425820305E068-30204
chr172582048925820630E068-29879
chr172582064025820717E068-29792
chr172582076525820815E068-29694
chr172582226725822356E068-28153
chr172582243925822489E068-28020
chr172582254425822797E068-27712
chr172582282525822868E068-27641
chr172582291525823028E068-27481
chr172582308025824051E068-26458
chr172582417925824247E068-26262
chr172582433325824433E068-26076
chr172582636525826425E068-24084
chr172582658225826782E068-23727
chr172582679325826843E068-23666
chr172582687725826931E068-23578
chr172582707625827148E068-23361
chr172582717525827215E068-23294
chr172582744125827507E068-23002
chr172582792225828074E068-22435
chr172582822025828316E068-22193
chr172582855925828609E068-21900
chr172582910425829325E068-21184
chr172582935125829467E068-21042
chr172582949525830212E068-20297
chr172583025225830453E068-20056
chr172583053125830581E068-19928
chr172583063225831031E068-19478
chr172583108625831253E068-19256
chr172583125925831543E068-18966
chr172583161925831980E068-18529
chr172583212825832248E068-18261
chr172583226325832668E068-17841
chr172583709525837187E068-13322
chr172583759725837663E068-12846
chr172583786225837917E068-12592
chr172583805525838108E068-12401
chr172583813925838332E068-12177
chr172583835225838515E068-11994
chr172583857125838721E068-11788
chr172583873825838926E068-11583
chr172583896025839156E068-11353
chr172583927525839372E068-11137
chr172583960525839655E068-10854
chr172583969825839809E068-10700
chr172583981425839984E068-10525
chr172584002925840239E068-10270
chr172584048325840533E068-9976
chr172584058825841469E068-9040
chr172584175125842133E068-8376
chr172584221425842289E068-8220
chr172584238125842607E068-7902
chr172584282425843103E068-7406
chr172584311425843465E068-7044
chr172584351325843563E068-6946
chr172584451125844551E068-5958
chr172584457425844672E068-5837
chr172584501825845096E068-5413
chr172584525525845305E068-5204
chr172584571525846061E068-4448
chr172584608925846460E068-4049
chr172584652725846791E068-3718
chr172584680325846856E068-3653
chr172584690225846999E068-3510
chr172584702025847087E068-3422
chr172584709625847146E068-3363
chr172584717725847562E068-2947
chr172584759225847802E068-2707
chr172584783825848207E068-2302
chr172584821525848288E068-2221
chr172584829625848340E068-2169
chr172584843225848589E068-1920
chr172584867525849078E068-1431
chr172584916525849251E068-1258
chr172584936725849594E068-915
chr172585180425851884E0681295
chr172585223725852314E0681728
chr172585231925852386E0681810
chr172585239025852917E0681881
chr172585329725853355E0682788
chr172585339425853482E0682885
chr172585439925854453E0683890
chr172585607225857168E0685563
chr172585746425857646E0686955
chr172585770925860268E0687200
chr172586027325860352E0689764
chr172586076525861038E06810256
chr172586105025861533E06810541
chr172586153925861784E06811030
chr172586185525862125E06811346
chr172586226125863410E06811752
chr172586342625863619E06812917
chr172586384725863901E06813338
chr172586391725863989E06813408
chr172586512925865223E06814620
chr172586532425865403E06814815
chr172586541125865468E06814902
chr172586547725865601E06814968
chr172586564625865840E06815137
chr172586586625866020E06815357
chr172586603325866190E06815524
chr172586621125866319E06815702
chr172586638225866503E06815873
chr172586656425866809E06816055
chr172586689725868325E06816388
chr172586836125868448E06817852
chr172586847725868527E06817968
chr172586854825868816E06818039
chr172586883925868921E06818330
chr172586894625869155E06818437
chr172586953025869582E06819021
chr172586960325869666E06819094
chr172586968525869850E06819176
chr172586988225870240E06819373
chr172587037925870419E06819870
chr172587065425870858E06820145
chr172587230825872540E06821799
chr172587254125872670E06822032
chr172587270025873239E06822191
chr172587335825873408E06822849
chr172587358225873743E06823073
chr172587638325876556E06825874
chr172587663425876852E06826125
chr172587689025876961E06826381
chr172587746125877672E06826952
chr172587777125877987E06827262
chr172587985925880527E06829350
chr172588053525880815E06830026
chr172588087225880997E06830363
chr172589362725894127E06843118
chr172589430425894360E06843795
chr172589442425894486E06843915
chr172589452625894915E06844017
chr172589507925895133E06844570
chr172589523925895289E06844730
chr172589533425895426E06844825
chr172589544725895541E06844938
chr172589560925895659E06845100
chr172589574625895837E06845237
chr172589591025896077E06845401
chr172589622825896818E06845719
chr172589687925897754E06846370
chr172589779825897855E06847289
chr172589786725897935E06847358
chr172589800325898156E06847494
chr172580341125803494E069-47015
chr172580360625803810E069-46699
chr172580691325806971E069-43538
chr172580758725807731E069-42778
chr172580780625807868E069-42641
chr172580788925807997E069-42512
chr172580810825808162E069-42347
chr172580833125808748E069-41761
chr172580875325808825E069-41684
chr172581236325812542E069-37967
chr172581270425812748E069-37761
chr172581280725812902E069-37607
chr172581292125812973E069-37536
chr172581301625813070E069-37439
chr172581314225813341E069-37168
chr172581603625816471E069-34038
chr172581663725816681E069-33828
chr172581676225816821E069-33688
chr172581695125817034E069-33475
chr172582021425820305E069-30204
chr172582048925820630E069-29879
chr172582064025820717E069-29792
chr172582076525820815E069-29694
chr172582095225822157E069-28352
chr172582226725822356E069-28153
chr172582243925822489E069-28020
chr172582254425822797E069-27712
chr172582282525822868E069-27641
chr172582291525823028E069-27481
chr172582308025824051E069-26458
chr172582417925824247E069-26262
chr172582433325824433E069-26076
chr172582448925824539E069-25970
chr172582636525826425E069-24084
chr172582658225826782E069-23727
chr172582679325826843E069-23666
chr172582687725826931E069-23578
chr172582707625827148E069-23361
chr172582717525827215E069-23294
chr172582744125827507E069-23002
chr172582910425829325E069-21184
chr172582935125829467E069-21042
chr172582949525830212E069-20297
chr172583025225830453E069-20056
chr172583053125830581E069-19928
chr172583063225831031E069-19478
chr172583108625831253E069-19256
chr172583125925831543E069-18966
chr172583161925831980E069-18529
chr172583212825832248E069-18261
chr172583226325832668E069-17841
chr172583285025832941E069-17568
chr172583498725835067E069-15442
chr172583508325835133E069-15376
chr172583539325835457E069-15052
chr172583557325835613E069-14896
chr172583603125836346E069-14163
chr172583759725837663E069-12846
chr172583786225837917E069-12592
chr172583805525838108E069-12401
chr172583813925838332E069-12177
chr172583835225838515E069-11994
chr172583857125838721E069-11788
chr172583873825838926E069-11583
chr172583896025839156E069-11353
chr172583927525839372E069-11137
chr172583960525839655E069-10854
chr172583969825839809E069-10700
chr172583981425839984E069-10525
chr172584002925840239E069-10270
chr172584048325840533E069-9976
chr172584058825841469E069-9040
chr172584175125842133E069-8376
chr172584221425842289E069-8220
chr172584238125842607E069-7902
chr172584282425843103E069-7406
chr172584311425843465E069-7044
chr172584501825845096E069-5413
chr172584525525845305E069-5204
chr172584571525846061E069-4448
chr172584608925846460E069-4049
chr172584652725846791E069-3718
chr172584680325846856E069-3653
chr172584690225846999E069-3510
chr172584702025847087E069-3422
chr172584709625847146E069-3363
chr172584717725847562E069-2947
chr172584759225847802E069-2707
chr172584783825848207E069-2302
chr172584821525848288E069-2221
chr172584829625848340E069-2169
chr172584843225848589E069-1920
chr172584867525849078E069-1431
chr172584916525849251E069-1258
chr172584936725849594E069-915
chr172585223725852314E0691728
chr172585231925852386E0691810
chr172585239025852917E0691881
chr172585329725853355E0692788
chr172585339425853482E0692885
chr172585353725854144E0693028
chr172585770925860268E0697200
chr172586027325860352E0699764
chr172586076525861038E06910256
chr172586105025861533E06910541
chr172586153925861784E06911030
chr172586185525862125E06911346
chr172586226125863410E06911752
chr172586342625863619E06912917
chr172586384725863901E06913338
chr172586391725863989E06913408
chr172586512925865223E06914620
chr172586532425865403E06914815
chr172586541125865468E06914902
chr172586547725865601E06914968
chr172586564625865840E06915137
chr172586586625866020E06915357
chr172586603325866190E06915524
chr172586621125866319E06915702
chr172586638225866503E06915873
chr172586656425866809E06916055
chr172586689725868325E06916388
chr172586836125868448E06917852
chr172586847725868527E06917968
chr172586854825868816E06918039
chr172586883925868921E06918330
chr172586894625869155E06918437
chr172586953025869582E06919021
chr172586960325869666E06919094
chr172586968525869850E06919176
chr172586988225870240E06919373
chr172587037925870419E06919870
chr172587065425870858E06920145
chr172587270025873239E06922191
chr172587335825873408E06922849
chr172587358225873743E06923073
chr172587375025874160E06923241
chr172587598725876371E06925478
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