rs1778365

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0266 (7941/29754,GnomAD)
A==0247 (7195/29118,TOPMED)
A==0330 (1653/5008,1000G)
A==0285 (1099/3854,ALSPAC)
A==0286 (1059/3708,TWINSUK)
chr14:41297358 (GRCh38.p7) (14q21.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.41297358A>G
GRCh37.p13 chr 14NC_000014.8:g.41766561A>G
LOC100533628 pseudogeneNG_028872.1:g.1049A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.170G=0.830
1000GenomesAmericanSub694A=0.280G=0.720
1000GenomesEast AsianSub1008A=0.532G=0.468
1000GenomesEuropeSub1006A=0.268G=0.732
1000GenomesGlobalStudy-wide5008A=0.330G=0.670
1000GenomesSouth AsianSub978A=0.430G=0.570
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.285G=0.715
The Genome Aggregation DatabaseAfricanSub8708A=0.214G=0.786
The Genome Aggregation DatabaseAmericanSub824A=0.270G=0.730
The Genome Aggregation DatabaseEast AsianSub1570A=0.501G=0.499
The Genome Aggregation DatabaseEuropeSub18350A=0.272G=0.727
The Genome Aggregation DatabaseGlobalStudy-wide29754A=0.266G=0.733
The Genome Aggregation DatabaseOtherSub302A=0.250G=0.750
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.247G=0.752
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.286G=0.714
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs17783650.000393nicotine dependence17158188

eQTL of rs1778365 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1778365 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr144175450541754720E070-11841
chr144174720041747372E081-19189
chr144174720041747372E082-19189