rs1778400

Homo sapiens
T>A
None
Check p-value
SNV (Single Nucleotide Variation)
T==0242 (7248/29934,GnomAD)
T==0225 (6578/29118,TOPMED)
T==0248 (1242/5008,1000G)
T==0283 (1092/3854,ALSPAC)
T==0279 (1033/3708,TWINSUK)
chr14:41250935 (GRCh38.p7) (14q21.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.41250935T>A
GRCh37.p13 chr 14NC_000014.8:g.41720138T>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.148A=0.852
1000GenomesAmericanSub694T=0.210A=0.790
1000GenomesEast AsianSub1008T=0.303A=0.697
1000GenomesEuropeSub1006T=0.264A=0.736
1000GenomesGlobalStudy-wide5008T=0.248A=0.752
1000GenomesSouth AsianSub978T=0.340A=0.660
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.283A=0.717
The Genome Aggregation DatabaseAfricanSub8708T=0.186A=0.814
The Genome Aggregation DatabaseAmericanSub838T=0.170A=0.830
The Genome Aggregation DatabaseEast AsianSub1616T=0.306A=0.694
The Genome Aggregation DatabaseEuropeSub18472T=0.266A=0.733
The Genome Aggregation DatabaseGlobalStudy-wide29934T=0.242A=0.757
The Genome Aggregation DatabaseOtherSub300T=0.240A=0.760
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.225A=0.774
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.279A=0.721
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs17784000.000143nicotine dependence17158188

eQTL of rs1778400 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1778400 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr144175450541754720E07034367
chr144174720041747372E08127062
chr144174720041747372E08227062