rs1778408

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0266 (7956/29814,GnomAD)
T==0246 (7190/29116,TOPMED)
T==0330 (1651/5008,1000G)
T==0285 (1098/3854,ALSPAC)
T==0285 (1057/3708,TWINSUK)
chr14:41274991 (GRCh38.p7) (14q21.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.41274991T>C
GRCh37.p13 chr 14NC_000014.8:g.41744194T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.169C=0.831
1000GenomesAmericanSub694T=0.280C=0.720
1000GenomesEast AsianSub1008T=0.532C=0.468
1000GenomesEuropeSub1006T=0.267C=0.733
1000GenomesGlobalStudy-wide5008T=0.330C=0.670
1000GenomesSouth AsianSub978T=0.430C=0.570
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.285C=0.715
The Genome Aggregation DatabaseAfricanSub8710T=0.214C=0.786
The Genome Aggregation DatabaseAmericanSub836T=0.270C=0.730
The Genome Aggregation DatabaseEast AsianSub1560T=0.501C=0.499
The Genome Aggregation DatabaseEuropeSub18406T=0.272C=0.727
The Genome Aggregation DatabaseGlobalStudy-wide29814T=0.266C=0.733
The Genome Aggregation DatabaseOtherSub302T=0.260C=0.740
Trans-Omics for Precision MedicineGlobalStudy-wide29116T=0.246C=0.753
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.285C=0.715
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs17784080.000437nicotine dependence17158188

eQTL of rs1778408 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1778408 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr144175450541754720E07010311
chr144174720041747372E0813006
chr144174720041747372E0823006