rs17784945

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0058 (1746/29968,GnomAD)
G=0063 (1844/29118,TOPMED)
G=0044 (219/5008,1000G)
G=0077 (296/3854,ALSPAC)
G=0081 (302/3708,TWINSUK)
chr8:23833760 (GRCh38.p7) (8p21.2)
AD
GWASdb2
1   publication(s)
See rs on genome
31 Enhancers around
6 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.23833760A>G
GRCh37.p13 chr 8NC_000008.10:g.23691273A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.987G=0.013
1000GenomesAmericanSub694A=0.920G=0.080
1000GenomesEast AsianSub1008A=0.945G=0.055
1000GenomesEuropeSub1006A=0.929G=0.071
1000GenomesGlobalStudy-wide5008A=0.956G=0.044
1000GenomesSouth AsianSub978A=0.980G=0.020
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.923G=0.077
The Genome Aggregation DatabaseAfricanSub8732A=0.977G=0.023
The Genome Aggregation DatabaseAmericanSub836A=0.900G=0.100
The Genome Aggregation DatabaseEast AsianSub1612A=0.948G=0.052
The Genome Aggregation DatabaseEuropeSub18486A=0.926G=0.073
The Genome Aggregation DatabaseGlobalStudy-wide29968A=0.941G=0.058
The Genome Aggregation DatabaseOtherSub302A=0.960G=0.040
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.936G=0.063
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.919G=0.081
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs177849450.00055Alcohol dependence (early age of onset)20201924
rs177849450.00098alcohol dependence20201924

eQTL of rs17784945 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs17784945 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr82370695723707088E07015684
chr82370712023707174E07015847
chr82370767923707837E07016406
chr82370792523708347E07016652
chr82370912523709179E07017852
chr82370933423709386E07018061
chr82371295223712992E07021679
chr82371650123717242E07025228
chr82371751823718220E07026245
chr82371826323719119E07026990
chr82371926023719453E07027987
chr82371949223719753E07028219
chr82371980423719925E07028531
chr82371995823720008E07028685
chr82372003823720088E07028765
chr82372020223720377E07028929
chr82370767923707837E08116406
chr82370792523708347E08116652
chr82371557323715920E08124300
chr82371624123716299E08124968
chr82371650123717242E08125228
chr82371751823718220E08126245
chr82371826323719119E08126990
chr82371926023719453E08127987
chr82371949223719753E08128219
chr82371980423719925E08128531
chr82371995823720008E08128685
chr82370792523708347E08216652
chr82371295223712992E08221679
chr82371650123717242E08225228
chr82371751823718220E08226245



Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr82371058623712716E07019313
chr82371058623712716E07219313
chr82371058623712716E07319313
chr82371058623712716E07419313
chr82371058623712716E08119313
chr82371058623712716E08219313