rs17786105

Homo sapiens
A>G
SLC9A8 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0271 (8125/29950,GnomAD)
G=0287 (8357/29118,TOPMED)
G=0222 (1112/5008,1000G)
G=0339 (1305/3854,ALSPAC)
G=0337 (1250/3708,TWINSUK)
chr20:49850348 (GRCh38.p7) (20q13.13)
AD
GWASdb2
1   publication(s)
See rs on genome
256 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 20NC_000020.11:g.49850348A>G
GRCh37.p13 chr 20NC_000020.10:g.48466885A>G

Gene: SLC9A8, solute carrier family 9 member A8(plus strand)

Molecule type Change Amino acid[Codon] SO Term
SLC9A8 transcript variant 1NM_001260491.1:c.N/AIntron Variant
SLC9A8 transcript variant 2NM_015266.2:c.N/AIntron Variant
SLC9A8 transcript variant 3NR_048537.1:n.N/AIntron Variant
SLC9A8 transcript variant 4NR_048538.1:n.N/AIntron Variant
SLC9A8 transcript variant 5NR_048539.1:n.N/AIntron Variant
SLC9A8 transcript variant 6NR_048540.1:n.N/AIntron Variant
SLC9A8 transcript variant X2XM_006723756.1:c.N/AIntron Variant
SLC9A8 transcript variant X1XM_011528736.1:c.N/AIntron Variant
SLC9A8 transcript variant X3XM_011528737.1:c.N/AIntron Variant
SLC9A8 transcript variant X4XM_011528738.1:c.N/AIntron Variant
SLC9A8 transcript variant X5XM_011528739.1:c.N/AIntron Variant
SLC9A8 transcript variant X7XM_011528740.1:c.N/AIntron Variant
SLC9A8 transcript variant X8XM_011528741.1:c.N/AIntron Variant
SLC9A8 transcript variant X10XM_011528742.1:c.N/AIntron Variant
SLC9A8 transcript variant X14XM_011528745.1:c.N/AIntron Variant
SLC9A8 transcript variant X6XM_017027754.1:c.N/AIntron Variant
SLC9A8 transcript variant X9XM_017027755.1:c.N/AIntron Variant
SLC9A8 transcript variant X12XM_017027756.1:c.N/AIntron Variant
SLC9A8 transcript variant X11XM_011528743.2:c.N/AGenic Upstream Transcript Variant
SLC9A8 transcript variant X13XM_011528744.2:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.820G=0.180
1000GenomesAmericanSub694A=0.740G=0.260
1000GenomesEast AsianSub1008A=0.843G=0.157
1000GenomesEuropeSub1006A=0.636G=0.364
1000GenomesGlobalStudy-wide5008A=0.778G=0.222
1000GenomesSouth AsianSub978A=0.830G=0.170
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.661G=0.339
The Genome Aggregation DatabaseAfricanSub8720A=0.783G=0.217
The Genome Aggregation DatabaseAmericanSub834A=0.740G=0.260
The Genome Aggregation DatabaseEast AsianSub1618A=0.834G=0.166
The Genome Aggregation DatabaseEuropeSub18478A=0.693G=0.306
The Genome Aggregation DatabaseGlobalStudy-wide29950A=0.728G=0.271
The Genome Aggregation DatabaseOtherSub300A=0.700G=0.300
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.713G=0.287
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.663G=0.337
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs177861050.00015alcohol dependence(early age of onset)20201924
rs177861050.00068alcohol dependence20201924

eQTL of rs17786105 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr20:48466885SLC9A8ENSG00000197818.7A>G2.4780e-1137635Cerebellum
Chr20:48466885SLC9A8ENSG00000197818.7A>G1.9733e-837635Cerebellar_Hemisphere

meQTL of rs17786105 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr204846682148467353E0670
chr204846738048467443E067495
chr204846745048467740E067565
chr204846775548468209E067870
chr204846823348468545E0671348
chr204846860648468760E0671721
chr204846888748468988E0672002
chr204846919348469318E0672308
chr204848484048484954E06717955
chr204848508848485254E06718203
chr204850330448503454E06736419
chr204850349348505502E06736608
chr204850557648505698E06738691
chr204850571948505787E06738834
chr204850590648506188E06739021
chr204850695848508069E06740073
chr204850815448508481E06741269
chr204850859848508648E06741713
chr204850866148508731E06741776
chr204850874548508795E06741860
chr204850881048509120E06741925
chr204850918048509422E06742295
chr204850949548509844E06742610
chr204851003748510103E06743152
chr204851014148510188E06743256
chr204851020448510285E06743319
chr204851031648510557E06743431
chr204851064748510687E06743762
chr204851069548510777E06743810
chr204851080548510980E06743920
chr204851617948516300E06749294
chr204851633548516386E06749450
chr204851642148516535E06749536
chr204851654348516781E06749658
chr204846682148467353E0680
chr204846738048467443E068495
chr204846745048467740E068565
chr204846775548468209E068870
chr204846823348468545E0681348
chr204846860648468760E0681721
chr204846888748468988E0682002
chr204846919348469318E0682308
chr204847021148470679E0683326
chr204847075948471100E0683874
chr204847110448471390E0684219
chr204848484048484954E06817955
chr204848508848485254E06818203
chr204848564548485705E06818760
chr204849443748494644E06827552
chr204850349348505502E06836608
chr204850557648505698E06838691
chr204850571948505787E06838834
chr204850590648506188E06839021
chr204850695848508069E06840073
chr204850815448508481E06841269
chr204850859848508648E06841713
chr204850866148508731E06841776
chr204850874548508795E06841860
chr204850881048509120E06841925
chr204850918048509422E06842295
chr204850949548509844E06842610
chr204851617948516300E06849294
chr204851633548516386E06849450
chr204851642148516535E06849536
chr204851654348516781E06849658
chr204846738048467443E069495
chr204846745048467740E069565
chr204846775548468209E069870
chr204846823348468545E0691348
chr204846860648468760E0691721
chr204846888748468988E0692002
chr204846919348469318E0692308
chr204849395848494358E06927073
chr204850330448503454E06936419
chr204850349348505502E06936608
chr204850557648505698E06938691
chr204850571948505787E06938834
chr204850590648506188E06939021
chr204850618948506325E06939304
chr204850646748506782E06939582
chr204850681848506898E06939933
chr204850695848508069E06940073
chr204850815448508481E06941269
chr204850859848508648E06941713
chr204850866148508731E06941776
chr204850874548508795E06941860
chr204850881048509120E06941925
chr204850918048509422E06942295
chr204850949548509844E06942610
chr204851003748510103E06943152
chr204851014148510188E06943256
chr204851020448510285E06943319
chr204851031648510557E06943431
chr204851064748510687E06943762
chr204851069548510777E06943810
chr204851617948516300E06949294
chr204851633548516386E06949450
chr204850695848508069E07040073
chr204844694548446995E071-19890
chr204844883048449150E071-17735
chr204846775548468209E071870
chr204846823348468545E0711348
chr204846860648468760E0711721
chr204846888748468988E0712002
chr204846919348469318E0712308
chr204850278748502955E07135902
chr204850299048503040E07136105
chr204850309948503239E07136214
chr204850330448503454E07136419
chr204850349348505502E07136608
chr204850557648505698E07138691
chr204850571948505787E07138834
chr204850590648506188E07139021
chr204850618948506325E07139304
chr204850646748506782E07139582
chr204850681848506898E07139933
chr204850695848508069E07140073
chr204850815448508481E07141269
chr204850859848508648E07141713
chr204850866148508731E07141776
chr204850874548508795E07141860
chr204850881048509120E07141925
chr204850918048509422E07142295
chr204850949548509844E07142610
chr204851003748510103E07143152
chr204851014148510188E07143256
chr204851020448510285E07143319
chr204851031648510557E07143431
chr204851064748510687E07143762
chr204851069548510777E07143810
chr204851080548510980E07143920
chr204844883048449150E072-17735
chr204846682148467353E0720
chr204846738048467443E072495
chr204846745048467740E072565
chr204846775548468209E072870
chr204846823348468545E0721348
chr204846860648468760E0721721
chr204846888748468988E0722002
chr204846919348469318E0722308
chr204850299048503040E07236105
chr204850309948503239E07236214
chr204850330448503454E07236419
chr204850349348505502E07236608
chr204850557648505698E07238691
chr204850571948505787E07238834
chr204850590648506188E07239021
chr204850618948506325E07239304
chr204850646748506782E07239582
chr204850681848506898E07239933
chr204850695848508069E07240073
chr204850815448508481E07241269
chr204850859848508648E07241713
chr204850866148508731E07241776
chr204850874548508795E07241860
chr204850881048509120E07241925
chr204850918048509422E07242295
chr204850949548509844E07242610
chr204851003748510103E07243152
chr204851014148510188E07243256
chr204851020448510285E07243319
chr204851031648510557E07243431
chr204851617948516300E07249294
chr204851633548516386E07249450
chr204851642148516535E07249536
chr204851654348516781E07249658
chr204844836748448773E073-18112
chr204846745048467740E073565
chr204846775548468209E073870
chr204846823348468545E0731348
chr204846860648468760E0731721
chr204848414448484247E07317259
chr204848447048484642E07317585
chr204848484048484954E07317955
chr204848508848485254E07318203
chr204850278748502955E07335902
chr204850299048503040E07336105
chr204850309948503239E07336214
chr204850330448503454E07336419
chr204850349348505502E07336608
chr204850557648505698E07338691
chr204850571948505787E07338834
chr204850590648506188E07339021
chr204850618948506325E07339304
chr204850646748506782E07339582
chr204850681848506898E07339933
chr204850695848508069E07340073
chr204850815448508481E07341269
chr204850859848508648E07341713
chr204850866148508731E07341776
chr204850874548508795E07341860
chr204850881048509120E07341925
chr204850918048509422E07342295
chr204850949548509844E07342610
chr204851003748510103E07343152
chr204851014148510188E07343256
chr204851020448510285E07343319
chr204851080548510980E07343920
chr204851617948516300E07349294
chr204851633548516386E07349450
chr204851642148516535E07349536
chr204851654348516781E07349658
chr204844657048446620E074-20265
chr204844679648446878E074-20007
chr204844694548446995E074-19890
chr204846682148467353E0740
chr204846738048467443E074495
chr204846745048467740E074565
chr204846775548468209E074870
chr204846823348468545E0741348
chr204846860648468760E0741721
chr204846888748468988E0742002
chr204846919348469318E0742308
chr204848484048484954E07417955
chr204848508848485254E07418203
chr204850349348505502E07436608
chr204850557648505698E07438691
chr204850571948505787E07438834
chr204850590648506188E07439021
chr204850618948506325E07439304
chr204850646748506782E07439582
chr204850681848506898E07439933
chr204850695848508069E07440073
chr204850815448508481E07441269
chr204850859848508648E07441713
chr204850866148508731E07441776
chr204850874548508795E07441860
chr204850881048509120E07441925
chr204851003748510103E07443152
chr204851014148510188E07443256
chr204851020448510285E07443319
chr204851031648510557E07443431
chr204851064748510687E07443762
chr204851069548510777E07443810
chr204851080548510980E07443920
chr204851143648511519E07444551
chr204851617948516300E07449294
chr204851633548516386E07449450
chr204851642148516535E07449536
chr204851654348516781E07449658
chr204850265648502746E08135771
chr204850278748502955E08135902
chr204850299048503040E08136105
chr204850309948503239E08136214
chr204850330448503454E08136419
chr204850349348505502E08136608
chr204850557648505698E08138691
chr204850571948505787E08138834
chr204850590648506188E08139021
chr204850618948506325E08139304
chr204850646748506782E08139582
chr204850681848506898E08139933
chr204850309948503239E08236214
chr204850330448503454E08236419
chr204850349348505502E08236608
chr204850557648505698E08238691










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr204842821748430084E067-36801
chr204842821748430084E068-36801
chr204842821748430084E069-36801
chr204842821748430084E070-36801
chr204842821748430084E071-36801
chr204842821748430084E072-36801
chr204842821748430084E073-36801
chr204842821748430084E074-36801
chr204842821748430084E081-36801
chr204842821748430084E082-36801