rs17855121

Homo sapiens
T>C
STX1B : Synonymous Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0241 (28905/119796,ExAC)
C=0251 (7462/29732,GnomAD)
C=0210 (6121/29118,TOPMED)
T==0248 (3222/12994,GO-ESP)
C=0153 (764/5008,1000G)
C=0290 (1117/3854,ALSPAC)
C=0281 (1042/3708,TWINSUK)
chr16:30992848 (GRCh38.p7) (16p11.2)
AD
GWASdb2
1   publication(s)
See rs on genome
77 Enhancers around
69 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.30992848T>C
GRCh37.p13 chr 16NC_000016.9:g.31004169T>C
STX1B RefSeqGeneNG_041829.1:g.22661A>G

Gene: STX1B, syntaxin 1B(minus strand)

Molecule type Change Amino acid[Codon] SO Term
STX1B transcriptNM_052874.4:c.840A>GS [TCA]> S [TCG]Coding Sequence Variant
syntaxin-1BNP_443106.1:p.Ser...NP_443106.1:p.Ser280=S [Ser]> S [Ser]Synonymous Variant
STX1B transcript variant X1XM_017022893.1:c....XM_017022893.1:c.822A>GS [TCA]> S [TCG]Coding Sequence Variant
syntaxin-1B isoform X1XP_016878382.1:p....XP_016878382.1:p.Ser274=S [Ser]> S [Ser]Synonymous Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.882C=0.118
1000GenomesAmericanSub694T=0.710C=0.290
1000GenomesEast AsianSub1008T=0.998C=0.002
1000GenomesEuropeSub1006T=0.711C=0.289
1000GenomesGlobalStudy-wide5008T=0.847C=0.153
1000GenomesSouth AsianSub978T=0.890C=0.110
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.710C=0.290
The Exome Aggregation ConsortiumAmericanSub21536T=0.763C=0.236
The Exome Aggregation ConsortiumAsianSub24888T=0.900C=0.099
The Exome Aggregation ConsortiumEuropeSub72486T=0.708C=0.291
The Exome Aggregation ConsortiumGlobalStudy-wide119796T=0.758C=0.241
The Exome Aggregation ConsortiumOtherSub886T=0.770C=0.230
The Genome Aggregation DatabaseAfricanSub8668T=0.861C=0.139
The Genome Aggregation DatabaseAmericanSub838T=0.710C=0.290
The Genome Aggregation DatabaseEast AsianSub1612T=0.997C=0.003
The Genome Aggregation DatabaseEuropeSub18314T=0.675C=0.324
The Genome Aggregation DatabaseGlobalStudy-wide29732T=0.749C=0.251
The Genome Aggregation DatabaseOtherSub300T=0.770C=0.230
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.789C=0.210
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.719C=0.281
PMID Title Author Journal
22481050Genetic influences on craving for alcohol.Agrawal AAddict Behav

P-Value

SNP ID p-value Traits Study
rs178551212.21E-05alcohol craving with or without dependence22481050

eQTL of rs17855121 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs17855121 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr163096447530965664E067-38505
chr163104319731043447E06739028
chr163104627131046384E06742102
chr163105013331050184E06745964
chr163097086130970983E068-33186
chr163104344931043644E06839280
chr163096447530965664E069-38505
chr163101328231014078E0699113
chr163101412831014359E0699959
chr163101905531019109E06914886
chr163104319731043447E06939028
chr163104344931043644E06939280
chr163104627131046384E06942102
chr163104930031049460E06945131
chr163104950331049543E06945334
chr163104981231049895E06945643
chr163104991131049996E06945742
chr163105013331050184E06945964
chr163105057631050626E06946407
chr163105075731050834E06946588
chr163097086130970983E070-33186
chr163099584730996041E070-8128
chr163101042131011035E0706252
chr163101105631011156E0706887
chr163101119631011272E0707027
chr163104319731043447E07039028
chr163096447530965664E071-38505
chr163101105631011156E0716887
chr163104319731043447E07139028
chr163104344931043644E07139280
chr163104627131046384E07142102
chr163104734631047493E07143177
chr163104767031047720E07143501
chr163104784031047905E07143671
chr163104930031049460E07145131
chr163104950331049543E07145334
chr163104981231049895E07145643
chr163104991131049996E07145742
chr163105013331050184E07145964
chr163105057631050626E07146407
chr163105075731050834E07146588
chr163105124131051357E07147072
chr163097086130970983E072-33186
chr163101323131013281E0729062
chr163101328231014078E0729113
chr163104319731043447E07239028
chr163096259730963385E073-40784
chr163097086130970983E073-33186
chr163101412831014359E0739959
chr163101441731015061E07310248
chr163101524731015297E07311078
chr163101530731015469E07311138
chr163101770031017856E07313531
chr163104344931043644E07339280
chr163104767031047720E07343501
chr163104784031047905E07343671
chr163096437230964449E074-39720
chr163096447530965664E074-38505
chr163104344931043644E07439280
chr163104627131046384E07442102
chr163104784031047905E07443671
chr163104813731048247E07443968
chr163104930031049460E07445131
chr163104950331049543E07445334
chr163104981231049895E07445643
chr163104991131049996E07445742
chr163105013331050184E07445964
chr163105057631050626E07446407
chr163105075731050834E07446588
chr163105124131051357E07447072
chr163096259730963385E081-40784
chr163096356430963604E081-40565
chr163101770031017856E08113531
chr163104319731043447E08139028
chr163104344931043644E08139280
chr163097086130970983E082-33186
chr163104250531042594E08238336










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr163095783230962529E067-41640
chr163096777430970858E067-33311
chr163102058131020656E06716412
chr163102071431020850E06716545
chr163102088131021013E06716712
chr163102168831021769E06717519
chr163102182331022594E06717654
chr163104374531046221E06739576
chr163095783230962529E068-41640
chr163096777430970858E068-33311
chr163102058131020656E06816412
chr163102071431020850E06816545
chr163102088131021013E06816712
chr163102168831021769E06817519
chr163102182331022594E06817654
chr163104374531046221E06839576
chr163095783230962529E069-41640
chr163096777430970858E069-33311
chr163102058131020656E06916412
chr163102071431020850E06916545
chr163102088131021013E06916712
chr163102168831021769E06917519
chr163102182331022594E06917654
chr163104374531046221E06939576
chr163095783230962529E070-41640
chr163096777430970858E070-33311
chr163102058131020656E07016412
chr163102071431020850E07016545
chr163102088131021013E07016712
chr163102168831021769E07017519
chr163102182331022594E07017654
chr163104374531046221E07039576
chr163095783230962529E071-41640
chr163096777430970858E071-33311
chr163102088131021013E07116712
chr163102168831021769E07117519
chr163102182331022594E07117654
chr163104374531046221E07139576
chr163095783230962529E072-41640
chr163096777430970858E072-33311
chr163102058131020656E07216412
chr163102071431020850E07216545
chr163102088131021013E07216712
chr163102168831021769E07217519
chr163102182331022594E07217654
chr163104374531046221E07239576
chr163095783230962529E073-41640
chr163096777430970858E073-33311
chr163102058131020656E07316412
chr163102071431020850E07316545
chr163102088131021013E07316712
chr163102168831021769E07317519
chr163102182331022594E07317654
chr163104374531046221E07339576
chr163095783230962529E074-41640
chr163096777430970858E074-33311
chr163102168831021769E07417519
chr163102182331022594E07417654
chr163104374531046221E07439576
chr163102088131021013E08116712
chr163104374531046221E08139576
chr163095783230962529E082-41640
chr163096777430970858E082-33311
chr163102058131020656E08216412
chr163102071431020850E08216545
chr163102088131021013E08216712
chr163102168831021769E08217519
chr163102182331022594E08217654
chr163104374531046221E08239576