rs1789891

Homo sapiens
C>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0135 (4049/29958,GnomAD)
A=0102 (2979/29118,TOPMED)
A=0095 (478/5008,1000G)
A=0157 (606/3854,ALSPAC)
A=0167 (618/3708,TWINSUK)
chr4:99329262 (GRCh38.p7) (4q23)
AD
GWASdb2 | GWASCatalog
12   publication(s)
See rs on genome
6 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.99329262C>A
GRCh37.p13 chr 4NC_000004.11:g.100250419C>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.990A=0.010
1000GenomesAmericanSub694C=0.850A=0.150
1000GenomesEast AsianSub1008C=0.948A=0.052
1000GenomesEuropeSub1006C=0.853A=0.147
1000GenomesGlobalStudy-wide5008C=0.905A=0.095
1000GenomesSouth AsianSub978C=0.830A=0.170
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.843A=0.157
The Genome Aggregation DatabaseAfricanSub8732C=0.961A=0.039
The Genome Aggregation DatabaseAmericanSub836C=0.810A=0.190
The Genome Aggregation DatabaseEast AsianSub1614C=0.937A=0.063
The Genome Aggregation DatabaseEuropeSub18474C=0.814A=0.185
The Genome Aggregation DatabaseGlobalStudy-wide29958C=0.864A=0.135
The Genome Aggregation DatabaseOtherSub302C=0.920A=0.080
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.897A=0.102
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.833A=0.167
PMID Title Author Journal
25045619The Genetics, Neurogenetics and Pharmacogenetics of Addiction.Demers CHCurr Behav Neurosci Rep
24735490Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population.Way MAddict Biol
26013422The ADH gene cluster SNP rs1789891 and temperamental dimensions in patients with alcohol dependence and affective disorders.Oniszczenko WScand J Psychol
20089146The ADH1B Arg47His polymorphism in east Asian populations and expansion of rice domestication in history.Peng YBMC Evol Biol
28714907Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.Treutlein JGenes (Basel)
22806211The genetics of addiction-a translational perspective.Agrawal ATransl Psychiatry
25035082XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans.Juraeva DNeuropsychopharmacology
22004471Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.Frank JAddict Biol
17273965Evidence of positive selection on a class I ADH locus.Han YAm J Hum Genet
25043041Neuropsychosocial profiles of current and future adolescent alcohol misusers.Whelan RNature
26849558Causal Role of Alcohol Consumption in an Improved Lipid Profile: The Atherosclerosis Risk in Communities (ARIC) Study.Vu KNPLoS One
21592108Diversification of the ADH1B gene during expansion of modern humans.Li HAnn Hum Genet

P-Value

SNP ID p-value Traits Study
rs17898910.00000001alcohol dependence22004471
rs17898911.00E-08alcohol dependence22004471
rs17898912.00E-08alcohol dependence28714907

eQTL of rs1789891 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr4:100250419ADH1CENSG00000248144.1C>A3.8914e-4-23765Brain_Spinal_cord_cervical

meQTL of rs1789891 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4100245602100245886E068-4533
chr4100221669100221897E070-28522
chr4100244954100245162E073-5257
chr4100245344100245493E073-4926
chr4100221669100221897E082-28522
chr4100222048100222444E082-27975