rs1789896

Homo sapiens
G>A / G>T
None
Check p-value
SNV (Single Nucleotide Variation)
G==0398 (11918/29904,GnomAD)
G==0332 (9691/29118,TOPMED)
G==0264 (1320/5008,1000G)
G==0470 (1810/3854,ALSPAC)
G==0478 (1774/3708,TWINSUK)
chr4:99335827 (GRCh38.p7) (4q23)
AD
GWASCatalog
3   publication(s)
See rs on genome
7 Enhancers around
37 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.99335827G>A
GRCh38.p7 chr 4NC_000004.12:g.99335827G>T
GRCh37.p13 chr 4NC_000004.11:g.100256984G>A
GRCh37.p13 chr 4NC_000004.11:g.100256984G>T
ADH1C RefSeqGeneNG_011718.1:g.21934C>T
ADH1C RefSeqGeneNG_011718.1:g.21934C>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.195A=0.805
1000GenomesAmericanSub694G=0.310A=0.690
1000GenomesEast AsianSub1008G=0.077A=0.923
1000GenomesEuropeSub1006G=0.455A=0.545
1000GenomesGlobalStudy-wide5008G=0.264A=0.736
1000GenomesSouth AsianSub978G=0.310A=0.690
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.470A=0.530
The Genome Aggregation DatabaseAfricanSub8728G=0.234A=0.766
The Genome Aggregation DatabaseAmericanSub834G=0.360A=0.640
The Genome Aggregation DatabaseEast AsianSub1612G=0.088A=0.912
The Genome Aggregation DatabaseEuropeSub18430G=0.505A=0.494
The Genome Aggregation DatabaseGlobalStudy-wide29904G=0.398A=0.601
The Genome Aggregation DatabaseOtherSub300G=0.370A=0.630
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.332A=0.667
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.478A=0.522
PMID Title Author Journal
24166409Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.Gelernter JMol Psychiatry
19298322Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans.Sherva RAlcohol Clin Exp Res
17273965Evidence of positive selection on a class I ADH locus.Han YAm J Hum Genet

P-Value

SNP ID p-value Traits Study
rs17898965E-06alcohol dependence24166409

eQTL of rs1789896 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1789896 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4100006643100006704E070-41710
chr4100006873100006947E070-41467
chr4100012091100012363E071-36051
chr4100006873100006947E081-41467
chr4100007948100008019E081-40395
chr4100006643100006704E082-41710
chr4100006873100006947E082-41467




Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr4100008829100008950E067-39464
chr4100009042100010625E067-37789
chr4100010636100011572E067-36842
chr4100008829100008950E068-39464
chr4100009042100010625E068-37789
chr4100010636100011572E068-36842
chr4100008645100008721E069-39693
chr4100008829100008950E069-39464
chr4100009042100010625E069-37789
chr4100010636100011572E069-36842
chr4100008158100008256E070-40158
chr4100008370100008613E070-39801
chr4100008645100008721E070-39693
chr4100008829100008950E070-39464
chr4100009042100010625E070-37789
chr4100010636100011572E070-36842
chr4100009042100010625E071-37789
chr4100010636100011572E071-36842
chr4100008829100008950E072-39464
chr4100009042100010625E072-37789
chr4100010636100011572E072-36842
chr4100008829100008950E073-39464
chr4100009042100010625E073-37789
chr4100010636100011572E073-36842
chr4100009042100010625E074-37789
chr4100010636100011572E074-36842
chr4100008645100008721E081-39693
chr4100008829100008950E081-39464
chr4100009042100010625E081-37789
chr4100010636100011572E081-36842
chr4100007472100007769E082-40645
chr4100008158100008256E082-40158
chr4100008370100008613E082-39801
chr4100008645100008721E082-39693
chr4100008829100008950E082-39464
chr4100009042100010625E082-37789
chr4100010636100011572E082-36842