SNP Detail Info-rs1850344

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0289 (8658/29934,GnomAD)
G=0273 (7970/29118,TOPMED)
G=0258 (1291/5008,1000G)
G=0386 (1488/3854,ALSPAC)
G=0402 (1492/3708,TWINSUK)

Position: chr3:107466226 (GRCh38.p7) (3q13.12)

Phenotype: AD

Dataset:

GWASdb2

Publications: 2 publication(s)

Genomic View: See rs on genome

Enhancer: 8 Enhancers around

Promoter: 20 Promoters around

Sequence Name	Change(s)
GRCh38.p7 chr 3	NC_000003.12:g.107466226A>G
GRCh37.p13 chr 3	NC_000003.11:g.107185073A>G

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.874	G=0.126
1000Genomes	American	Sub	694	A=0.700	G=0.300
1000Genomes	East Asian	Sub	1008	A=0.834	G=0.166
1000Genomes	Europe	Sub	1006	A=0.602	G=0.398
1000Genomes	Global	Study-wide	5008	A=0.742	G=0.258
1000Genomes	South Asian	Sub	978	A=0.640	G=0.360
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.614	G=0.386
The Genome Aggregation Database	African	Sub	8718	A=0.844	G=0.156
The Genome Aggregation Database	American	Sub	832	A=0.720	G=0.280
The Genome Aggregation Database	East Asian	Sub	1620	A=0.839	G=0.161
The Genome Aggregation Database	Europe	Sub	18462	A=0.637	G=0.362
The Genome Aggregation Database	Global	Study-wide	29934	A=0.710	G=0.289
The Genome Aggregation Database	Other	Sub	302	A=0.640	G=0.360
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.726	G=0.273
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.598	G=0.402

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res
23691058	Dosage transmission disequilibrium test (dTDT) for linkage and association detection.	Zhang Z	PLoS One

SNP ID	p-value	Traits	Study
rs1850344	0.00000816	alcohol dependence	23691058
rs1850344	0.000047	alcohol dependence	20201924
rs1850344	0.0000472	alcoholism	pha002892

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
Chr3:107185073	RP11-115H18.1	ENSG00000273125.1	A>G	3.7244e-14	35296	Caudate_basal_ganglia
Chr3:107185073	RP11-115H18.1	ENSG00000273125.1	A>G	3.8154e-9	35296	Putamen_basal_ganglia

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr3	107144807	107144912	E067	-40161
chr3	107138020	107138144	E068	-46929
chr3	107147323	107147566	E069	-37507
chr3	107147057	107147212	E071	-37861
chr3	107147323	107147566	E071	-37507
chr3	107135098	107135311	E074	-49762
chr3	107147057	107147212	E074	-37861
chr3	107147323	107147566	E074	-37507

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr3	107139713	107139763	E067	-45310
chr3	107139972	107140320	E067	-44753
chr3	107148216	107151362	E067	-33711
chr3	107139713	107139763	E068	-45310
chr3	107139972	107140320	E068	-44753
chr3	107148216	107151362	E068	-33711
chr3	107139972	107140320	E069	-44753
chr3	107148216	107151362	E069	-33711
chr3	107148216	107151362	E070	-33711
chr3	107139713	107139763	E071	-45310
chr3	107139972	107140320	E071	-44753
chr3	107148216	107151362	E071	-33711
chr3	107139713	107139763	E072	-45310
chr3	107139972	107140320	E072	-44753
chr3	107148216	107151362	E072	-33711
chr3	107148216	107151362	E073	-33711
chr3	107139713	107139763	E074	-45310
chr3	107139972	107140320	E074	-44753
chr3	107148216	107151362	E074	-33711
chr3	107148216	107151362	E082	-33711

rs1850344