rs1870424

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0143 (4308/29958,GnomAD)
C=0180 (5262/29118,TOPMED)
C=0145 (726/5008,1000G)
C=0179 (690/3854,ALSPAC)
C=0183 (680/3708,TWINSUK)
chr3:146514201 (GRCh38.p7) (3q24)
AD
GWASdb2
1   publication(s)
See rs on genome
22 Enhancers around
52 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.146514201T>C
GRCh37.p13 chr 3NC_000003.11:g.146231988T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.840C=0.160
1000GenomesAmericanSub694T=0.900C=0.100
1000GenomesEast AsianSub1008T=0.922C=0.078
1000GenomesEuropeSub1006T=0.814C=0.186
1000GenomesGlobalStudy-wide5008T=0.855C=0.145
1000GenomesSouth AsianSub978T=0.820C=0.180
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.821C=0.179
The Genome Aggregation DatabaseAfricanSub8712T=0.848C=0.152
The Genome Aggregation DatabaseAmericanSub838T=0.870C=0.130
The Genome Aggregation DatabaseEast AsianSub1616T=0.931C=0.069
The Genome Aggregation DatabaseEuropeSub18490T=0.852C=0.147
The Genome Aggregation DatabaseGlobalStudy-wide29958T=0.856C=0.143
The Genome Aggregation DatabaseOtherSub302T=0.880C=0.120
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.819C=0.180
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.817C=0.183
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs18704240.00099alcohol consumption (maxi-drinks)24277619

eQTL of rs1870424 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1870424 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3146231336146231502E067-486
chr3146231552146231683E067-305
chr3146231336146231502E068-486
chr3146231552146231683E068-305
chr3146255543146255644E06823555
chr3146254471146254915E06922483
chr3146254471146254915E07022483
chr3146186377146186555E071-45433
chr3146186576146186743E071-45245
chr3146224056146225431E071-6557
chr3146225538146225777E071-6211
chr3146257202146257421E07225214
chr3146257614146257706E07225626
chr3146186377146186555E073-45433
chr3146231336146231502E073-486
chr3146231552146231683E073-305
chr3146254471146254915E07322483
chr3146185973146186315E074-45673
chr3146186377146186555E074-45433
chr3146186576146186743E074-45245
chr3146224056146225431E074-6557
chr3146254471146254915E07422483








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr3146186808146186899E067-45089
chr3146186903146187001E067-44987
chr3146187026146187979E067-44009
chr3146259952146260357E06727964
chr3146260819146261906E06728831
chr3146261940146262874E06729952
chr3146186808146186899E068-45089
chr3146186903146187001E068-44987
chr3146187026146187979E068-44009
chr3146259952146260357E06827964
chr3146260819146261906E06828831
chr3146261940146262874E06829952
chr3146262926146263038E06830938
chr3146186903146187001E069-44987
chr3146187026146187979E069-44009
chr3146259952146260357E06927964
chr3146260819146261906E06928831
chr3146261940146262874E06929952
chr3146186903146187001E070-44987
chr3146187026146187979E070-44009
chr3146260819146261906E07028831
chr3146261940146262874E07029952
chr3146262926146263038E07030938
chr3146186808146186899E071-45089
chr3146186903146187001E071-44987
chr3146187026146187979E071-44009
chr3146259952146260357E07127964
chr3146260819146261906E07128831
chr3146261940146262874E07129952
chr3146186903146187001E072-44987
chr3146187026146187979E072-44009
chr3146259952146260357E07227964
chr3146260819146261906E07228831
chr3146261940146262874E07229952
chr3146186808146186899E073-45089
chr3146186903146187001E073-44987
chr3146187026146187979E073-44009
chr3146259952146260357E07327964
chr3146260819146261906E07328831
chr3146261940146262874E07329952
chr3146262926146263038E07330938
chr3146186903146187001E074-44987
chr3146187026146187979E074-44009
chr3146260819146261906E07428831
chr3146261940146262874E07429952
chr3146259952146260357E08127964
chr3146260819146261906E08128831
chr3146262926146263038E08130938
chr3146186903146187001E082-44987
chr3146187026146187979E082-44009
chr3146260819146261906E08228831
chr3146261940146262874E08229952