rs1874243

Homo sapiens
G>A / G>C
None
Check p-value
SNV (Single Nucleotide Variation)
G==0456 (13660/29900,GnomAD)
A=0484 (14099/29118,TOPMED)
G==0423 (2117/5008,1000G)
G==0413 (1592/3854,ALSPAC)
G==0412 (1528/3708,TWINSUK)
chr7:68363094 (GRCh38.p7) (7q11.22)
AD
GWASdb2
1   publication(s)
See rs on genome
283 Enhancers around
78 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.68363094G>A
GRCh38.p7 chr 7NC_000007.14:g.68363094G>C
GRCh37.p13 chr 7NC_000007.13:g.67828081G>A
GRCh37.p13 chr 7NC_000007.13:g.67828081G>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.701A=0.299
1000GenomesAmericanSub694G=0.370A=0.630
1000GenomesEast AsianSub1008G=0.189A=0.811
1000GenomesEuropeSub1006G=0.419A=0.581
1000GenomesGlobalStudy-wide5008G=0.423A=0.577
1000GenomesSouth AsianSub978G=0.330A=0.670
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.413A=0.587
The Genome Aggregation DatabaseAfricanSub8694G=0.631C=0.000
The Genome Aggregation DatabaseAmericanSub836G=0.320C=0.00,
The Genome Aggregation DatabaseEast AsianSub1616G=0.166C=0.000
The Genome Aggregation DatabaseEuropeSub18452G=0.406C=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29900G=0.456C=0.000
The Genome Aggregation DatabaseOtherSub302G=0.450C=0.00,
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.515A=0.484
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.412A=0.588
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs18742430.00076alcohol dependence20201924

eQTL of rs1874243 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1874243 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr76605774566058012E067-37219
chr76605808266058239E067-36992
chr76605831866058368E067-36863
chr76609525366095334E06722
chr76609540966095471E067178
chr76609547766095906E067246
chr76609753866097737E0672307
chr76609832266098372E0673091
chr76609921966099269E0673988
chr76609987466099954E0674643
chr76610002666100139E0674795
chr76610014066100438E0674909
chr76610107066101326E0675839
chr76610587666106219E06710645
chr76610635266106420E06711121
chr76610648266106690E06711251
chr76610677466106860E06711543
chr76612116066121328E06725929
chr76613137366131423E06736142
chr76613170766131757E06736476
chr76613195766132017E06736726
chr76613248266132561E06737251
chr76613332066133460E06738089
chr76613347066133510E06738239
chr76613358266133715E06738351
chr76613375966133901E06738528
chr76613416066134374E06738929
chr76613441866134539E06739187
chr76613460966134829E06739378
chr76613487066134941E06739639
chr76613512466135178E06739893
chr76613683866137100E06741607
chr76605470066054760E068-40471
chr76605481766054898E068-40333
chr76605533166055381E068-39850
chr76609525366095334E06822
chr76609540966095471E068178
chr76609547766095906E068246
chr76610587666106219E06810645
chr76610635266106420E06811121
chr76610648266106690E06811251
chr76610677466106860E06811543
chr76610728166107476E06812050
chr76612963566129970E06834404
chr76613170766131757E06836476
chr76613195766132017E06836726
chr76613248266132561E06837251
chr76613332066133460E06838089
chr76613347066133510E06838239
chr76613416066134374E06838929
chr76613441866134539E06839187
chr76613460966134829E06839378
chr76613487066134941E06839639
chr76613512466135178E06839893
chr76613528366135333E06840052
chr76613613766136191E06840906
chr76613631566136365E06841084
chr76605533166055381E069-39850
chr76605774566058012E069-37219
chr76605808266058239E069-36992
chr76609193366092780E069-2451
chr76609547766095906E069246
chr76609921966099269E0693988
chr76609987466099954E0694643
chr76610002666100139E0694795
chr76610014066100438E0694909
chr76610088866100967E0695657
chr76610107066101326E0695839
chr76610587666106219E06910645
chr76610635266106420E06911121
chr76610648266106690E06911251
chr76610677466106860E06911543
chr76610728166107476E06912050
chr76610777266107910E06912541
chr76612116066121328E06925929
chr76612963566129970E06934404
chr76613007666130129E06934845
chr76613040066130492E06935169
chr76613052766130613E06935296
chr76613073166130793E06935500
chr76613081866130878E06935587
chr76613099766131051E06935766
chr76613112166131182E06935890
chr76613124666131322E06936015
chr76613137366131423E06936142
chr76613170766131757E06936476
chr76613195766132017E06936726
chr76613248266132561E06937251
chr76613332066133460E06938089
chr76613347066133510E06938239
chr76613441866134539E06939187
chr76613460966134829E06939378
chr76613487066134941E06939639
chr76613512466135178E06939893
chr76613528366135333E06940052
chr76613613766136191E06940906
chr76613631566136365E06941084
chr76613683866137100E06941607
chr76614381266143862E06948581
chr76614389366144018E06948662
chr76614407366144316E06948842
chr76605470066054760E070-40471
chr76605533166055381E070-39850
chr76605774566058012E070-37219
chr76604546466045519E071-49712
chr76604644166046504E071-48727
chr76605180466051854E071-43377
chr76605205166052135E071-43096
chr76605216166052325E071-42906
chr76605808266058239E071-36992
chr76605831866058368E071-36863
chr76609547766095906E071246
chr76609832266098372E0713091
chr76609921966099269E0713988
chr76609987466099954E0714643
chr76610002666100139E0714795
chr76610482166105099E0719590
chr76610541466105538E07110183
chr76610587666106219E07110645
chr76610635266106420E07111121
chr76610648266106690E07111251
chr76610677466106860E07111543
chr76610728166107476E07112050
chr76610777266107910E07112541
chr76612116066121328E07125929
chr76612402766124077E07128796
chr76612433266124412E07129101
chr76612744866127605E07132217
chr76612764666127720E07132415
chr76612776666127895E07132535
chr76612796266128109E07132731
chr76612963566129970E07134404
chr76613007666130129E07134845
chr76613040066130492E07135169
chr76613052766130613E07135296
chr76613073166130793E07135500
chr76613081866130878E07135587
chr76613099766131051E07135766
chr76613112166131182E07135890
chr76613124666131322E07136015
chr76613137366131423E07136142
chr76613170766131757E07136476
chr76613195766132017E07136726
chr76613248266132561E07137251
chr76613332066133460E07138089
chr76613347066133510E07138239
chr76613358266133715E07138351
chr76613416066134374E07138929
chr76613441866134539E07139187
chr76613460966134829E07139378
chr76613487066134941E07139639
chr76613512466135178E07139893
chr76613528366135333E07140052
chr76613613766136191E07140906
chr76613631566136365E07141084
chr76613683866137100E07141607
chr76604546466045519E072-49712
chr76609193366092780E072-2451
chr76609540966095471E072178
chr76609547766095906E072246
chr76609987466099954E0724643
chr76610002666100139E0724795
chr76610014066100438E0724909
chr76610541466105538E07210183
chr76610587666106219E07210645
chr76610635266106420E07211121
chr76610648266106690E07211251
chr76610677466106860E07211543
chr76610728166107476E07212050
chr76612116066121328E07225929
chr76612402766124077E07228796
chr76612433266124412E07229101
chr76612963566129970E07234404
chr76613007666130129E07234845
chr76613040066130492E07235169
chr76613052766130613E07235296
chr76613073166130793E07235500
chr76613081866130878E07235587
chr76613099766131051E07235766
chr76613112166131182E07235890
chr76613124666131322E07236015
chr76613137366131423E07236142
chr76613170766131757E07236476
chr76613195766132017E07236726
chr76613248266132561E07237251
chr76613332066133460E07238089
chr76613487066134941E07239639
chr76613512466135178E07239893
chr76613528366135333E07240052
chr76613631566136365E07241084
chr76613819366138412E07242962
chr76605808266058239E073-36992
chr76605831866058368E073-36863
chr76605841866058517E073-36714
chr76605853166058652E073-36579
chr76609547766095906E073246
chr76610107066101326E0735839
chr76610541466105538E07310183
chr76610587666106219E07310645
chr76610635266106420E07311121
chr76610648266106690E07311251
chr76610677466106860E07311543
chr76610728166107476E07312050
chr76610777266107910E07312541
chr76610825466108308E07313023
chr76610831866108436E07313087
chr76610851466108621E07313283
chr76613007666130129E07334845
chr76613040066130492E07335169
chr76613052766130613E07335296
chr76613073166130793E07335500
chr76613195766132017E07336726
chr76613248266132561E07337251
chr76613332066133460E07338089
chr76613347066133510E07338239
chr76613358266133715E07338351
chr76613375966133901E07338528
chr76613416066134374E07338929
chr76613441866134539E07339187
chr76613460966134829E07339378
chr76613487066134941E07339639
chr76613512466135178E07339893
chr76613528366135333E07340052
chr76614389366144018E07348662
chr76614407366144316E07348842
chr76614437266144439E07349141
chr76604644166046504E074-48727
chr76605124266051350E074-43881
chr76605145966051509E074-43722
chr76605774566058012E074-37219
chr76605808266058239E074-36992
chr76609525366095334E07422
chr76609540966095471E074178
chr76609547766095906E074246
chr76610088866100967E0745657
chr76610107066101326E0745839
chr76610587666106219E07410645
chr76610635266106420E07411121
chr76610648266106690E07411251
chr76610677466106860E07411543
chr76610728166107476E07412050
chr76610777266107910E07412541
chr76612963566129970E07434404
chr76613007666130129E07434845
chr76613040066130492E07435169
chr76613052766130613E07435296
chr76613073166130793E07435500
chr76613081866130878E07435587
chr76613099766131051E07435766
chr76613112166131182E07435890
chr76613124666131322E07436015
chr76613137366131423E07436142
chr76613170766131757E07436476
chr76613195766132017E07436726
chr76613248266132561E07437251
chr76613332066133460E07438089
chr76613347066133510E07438239
chr76613358266133715E07438351
chr76613375966133901E07438528
chr76613416066134374E07438929
chr76613460966134829E07439378
chr76613487066134941E07439639
chr76613512466135178E07439893
chr76613528366135333E07440052
chr76613613766136191E07440906
chr76613631566136365E07441084
chr76613683866137100E07441607
chr76614381266143862E07448581
chr76614389366144018E07448662
chr76614407366144316E07448842
chr76609525366095334E08122
chr76609540966095471E081178
chr76609547766095906E081246
chr76612744866127605E08132217
chr76612764666127720E08132415
chr76612776666127895E08132535
chr76612796266128109E08132731
chr76605470066054760E082-40471
chr76605481766054898E082-40333
chr76605533166055381E082-39850
chr76605808266058239E082-36992
chr76605831866058368E082-36863
chr76609547766095906E082246










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr76605614666056288E067-38943
chr76605634166056446E067-38785
chr76605652866057719E067-37512
chr76609289066095047E067-184
chr76611866766118754E06723436
chr76611880966118871E06723578
chr76611892166120400E06723690
chr76612046966120697E06725238
chr76605614666056288E068-38943
chr76605634166056446E068-38785
chr76605652866057719E068-37512
chr76609289066095047E068-184
chr76611866766118754E06823436
chr76611880966118871E06823578
chr76611892166120400E06823690
chr76612046966120697E06825238
chr76605614666056288E069-38943
chr76605634166056446E069-38785
chr76605652866057719E069-37512
chr76609289066095047E069-184
chr76611866766118754E06923436
chr76611880966118871E06923578
chr76611892166120400E06923690
chr76612046966120697E06925238
chr76605614666056288E070-38943
chr76605634166056446E070-38785
chr76605652866057719E070-37512
chr76609289066095047E070-184
chr76611866766118754E07023436
chr76611880966118871E07023578
chr76611892166120400E07023690
chr76612046966120697E07025238
chr76605614666056288E071-38943
chr76605634166056446E071-38785
chr76605652866057719E071-37512
chr76609289066095047E071-184
chr76611866766118754E07123436
chr76611880966118871E07123578
chr76611892166120400E07123690
chr76612046966120697E07125238
chr76605614666056288E072-38943
chr76605634166056446E072-38785
chr76605652866057719E072-37512
chr76609289066095047E072-184
chr76611866766118754E07223436
chr76611880966118871E07223578
chr76611892166120400E07223690
chr76612046966120697E07225238
chr76605614666056288E073-38943
chr76605634166056446E073-38785
chr76605652866057719E073-37512
chr76609289066095047E073-184
chr76611866766118754E07323436
chr76611880966118871E07323578
chr76611892166120400E07323690
chr76612046966120697E07325238
chr76605614666056288E074-38943
chr76605634166056446E074-38785
chr76605652866057719E074-37512
chr76609289066095047E074-184
chr76611866766118754E07423436
chr76611880966118871E07423578
chr76611892166120400E07423690
chr76612046966120697E07425238
chr76605614666056288E081-38943
chr76605634166056446E081-38785
chr76605652866057719E081-37512
chr76611880966118871E08123578
chr76611892166120400E08123690
chr76612046966120697E08125238
chr76605614666056288E082-38943
chr76605634166056446E082-38785
chr76605652866057719E082-37512
chr76609289066095047E082-184
chr76611866766118754E08223436
chr76611880966118871E08223578
chr76611892166120400E08223690
chr76612046966120697E08225238