rs1874633

Homo sapiens
A>G
CENPC : Non Coding Transcript Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0384 (11487/29870,GnomAD)
A==0364 (10623/29118,TOPMED)
A==0298 (1492/5008,1000G)
A==0391 (1505/3854,ALSPAC)
A==0397 (1471/3708,TWINSUK)
chr4:67471717 (GRCh38.p7) (4q13.2)
AD
GWASdb2
1   publication(s)
See rs on genome
43 Enhancers around
1 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.67471717A>G
GRCh37.p13 chr 4NC_000004.11:g.68337435A>G

Gene: CENPC, centromere protein C(minus strand)

Molecule type Change Amino acid[Codon] SO Term
CENPC transcriptNM_001812.2:c.N/AGenic Downstream Transcript Variant
CENPC transcript variant X1XM_006714064.2:c.N/A3 Prime UTR Variant
CENPC transcript variant X3XM_011531542.2:c.N/AGenic Downstream Transcript Variant
CENPC transcript variant X2XR_245245.3:n.408...XR_245245.3:n.4084T>CT>CNon Coding Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.377G=0.623
1000GenomesAmericanSub694A=0.240G=0.760
1000GenomesEast AsianSub1008A=0.174G=0.826
1000GenomesEuropeSub1006A=0.375G=0.625
1000GenomesGlobalStudy-wide5008A=0.298G=0.702
1000GenomesSouth AsianSub978A=0.280G=0.720
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.391G=0.609
The Genome Aggregation DatabaseAfricanSub8678A=0.360G=0.640
The Genome Aggregation DatabaseAmericanSub834A=0.240G=0.760
The Genome Aggregation DatabaseEast AsianSub1616A=0.175G=0.825
The Genome Aggregation DatabaseEuropeSub18440A=0.422G=0.577
The Genome Aggregation DatabaseGlobalStudy-wide29870A=0.384G=0.615
The Genome Aggregation DatabaseOtherSub302A=0.310G=0.690
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.364G=0.635
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.397G=0.603
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs18746330.000303alcohol dependence20201924

eQTL of rs1874633 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1874633 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr46830252468302708E067-34727
chr46830369068303910E067-33525
chr46830397768304613E067-32822
chr46833071468330762E067-6673
chr46833127268331554E067-5881
chr46836496268365006E06727527
chr46836526968365527E06727834
chr46836563968365727E06728204
chr46836620768366298E06728772
chr46833127268331554E068-5881
chr46830252468302708E069-34727
chr46830369068303910E069-33525
chr46830397768304613E069-32822
chr46833071468330762E069-6673
chr46833127268331554E069-5881
chr46836496268365006E06927527
chr46836526968365527E06927834
chr46836563968365727E06928204
chr46836620768366298E06928772
chr46830252468302708E071-34727
chr46833127268331554E071-5881
chr46836496268365006E07127527
chr46836526968365527E07127834
chr46836563968365727E07128204
chr46836620768366298E07128772
chr46830369068303910E072-33525
chr46830397768304613E072-32822
chr46833071468330762E072-6673
chr46833127268331554E072-5881
chr46836496268365006E07227527
chr46836526968365527E07227834
chr46836563968365727E07228204
chr46836620768366298E07228772
chr46833071468330762E073-6673
chr46830252468302708E074-34727
chr46830369068303910E074-33525
chr46830397768304613E074-32822
chr46833127268331554E074-5881
chr46833162368331730E074-5705
chr46836496268365006E07427527
chr46836526968365527E07427834
chr46836563968365727E07428204
chr46836620768366298E07428772







Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr46831200668312191E082-25244