rs1880663

Homo sapiens
A>G
RAB6B : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0122 (3673/29968,GnomAD)
G=0104 (3048/29118,TOPMED)
G=0069 (344/5008,1000G)
G=0200 (770/3854,ALSPAC)
G=0205 (761/3708,TWINSUK)
chr3:133862615 (GRCh38.p7) (3q22.1)
AD
GWASdb2
1   publication(s)
See rs on genome
206 Enhancers around
43 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.133862615A>G
GRCh37.p13 chr 3NC_000003.11:g.133581459A>G

Gene: RAB6B, RAB6B, member RAS oncogene family(minus strand)

Molecule type Change Amino acid[Codon] SO Term
RAB6B transcriptNM_016577.3:c.N/AIntron Variant
RAB6B transcript variant X1XM_011512893.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.978G=0.022
1000GenomesAmericanSub694A=0.900G=0.100
1000GenomesEast AsianSub1008A=0.979G=0.021
1000GenomesEuropeSub1006A=0.853G=0.147
1000GenomesGlobalStudy-wide5008A=0.931G=0.069
1000GenomesSouth AsianSub978A=0.920G=0.080
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.800G=0.200
The Genome Aggregation DatabaseAfricanSub8728A=0.955G=0.045
The Genome Aggregation DatabaseAmericanSub836A=0.910G=0.090
The Genome Aggregation DatabaseEast AsianSub1620A=0.982G=0.018
The Genome Aggregation DatabaseEuropeSub18482A=0.830G=0.169
The Genome Aggregation DatabaseGlobalStudy-wide29968A=0.877G=0.122
The Genome Aggregation DatabaseOtherSub302A=0.830G=0.170
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.895G=0.104
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.795G=0.205
PMID Title Author Journal
21665994Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.Kutalik ZHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs18806633.79E-09alcohol consumption21665994

eQTL of rs1880663 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1880663 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3133562885133562960E067-18499
chr3133573215133573347E067-8112
chr3133573885133574171E067-7288
chr3133574725133574824E067-6635
chr3133575303133575377E067-6082
chr3133584047133584242E0672588
chr3133587242133587401E0675783
chr3133587644133588157E0676185
chr3133588170133588246E0676711
chr3133590458133590539E0678999
chr3133591508133591609E06710049
chr3133605430133605480E06723971
chr3133606068133606142E06724609
chr3133606609133606728E06725150
chr3133606737133606971E06725278
chr3133607051133607438E06725592
chr3133610595133610710E06729136
chr3133572273133572376E068-9083
chr3133572430133572579E068-8880
chr3133572588133572638E068-8821
chr3133573215133573347E068-8112
chr3133573885133574171E068-7288
chr3133574725133574824E068-6635
chr3133575303133575377E068-6082
chr3133584047133584242E0682588
chr3133587242133587401E0685783
chr3133587644133588157E0686185
chr3133588170133588246E0686711
chr3133590458133590539E0688999
chr3133591508133591609E06810049
chr3133599175133599394E06817716
chr3133600933133601305E06819474
chr3133601479133601597E06820020
chr3133601946133602097E06820487
chr3133605430133605480E06823971
chr3133606068133606142E06824609
chr3133606609133606728E06825150
chr3133606737133606971E06825278
chr3133607051133607438E06825592
chr3133610324133610406E06828865
chr3133610434133610546E06828975
chr3133610595133610710E06829136
chr3133610769133610850E06829310
chr3133610942133611109E06829483
chr3133611135133611246E06829676
chr3133611394133611727E06829935
chr3133611918133612048E06830459
chr3133612068133612226E06830609
chr3133540603133541021E069-40438
chr3133541191133541245E069-40214
chr3133572273133572376E069-9083
chr3133572430133572579E069-8880
chr3133572588133572638E069-8821
chr3133573215133573347E069-8112
chr3133573885133574171E069-7288
chr3133574725133574824E069-6635
chr3133575303133575377E069-6082
chr3133584047133584242E0692588
chr3133587242133587401E0695783
chr3133587644133588157E0696185
chr3133588170133588246E0696711
chr3133590458133590539E0698999
chr3133591508133591609E06910049
chr3133605430133605480E06923971
chr3133606068133606142E06924609
chr3133606609133606728E06925150
chr3133606737133606971E06925278
chr3133607051133607438E06925592
chr3133547093133547193E070-34266
chr3133547516133547745E070-33714
chr3133547924133548172E070-33287
chr3133572273133572376E070-9083
chr3133572430133572579E070-8880
chr3133572588133572638E070-8821
chr3133573215133573347E070-8112
chr3133573885133574171E070-7288
chr3133574725133574824E070-6635
chr3133575303133575377E070-6082
chr3133587242133587401E0705783
chr3133587644133588157E0706185
chr3133606609133606728E07025150
chr3133606737133606971E07025278
chr3133607051133607438E07025592
chr3133610769133610850E07029310
chr3133610942133611109E07029483
chr3133611135133611246E07029676
chr3133611394133611727E07029935
chr3133611918133612048E07030459
chr3133612068133612226E07030609
chr3133540337133540417E071-41042
chr3133572273133572376E071-9083
chr3133572430133572579E071-8880
chr3133572588133572638E071-8821
chr3133573215133573347E071-8112
chr3133573885133574171E071-7288
chr3133574725133574824E071-6635
chr3133582903133583150E0711444
chr3133584047133584242E0712588
chr3133587242133587401E0715783
chr3133587644133588157E0716185
chr3133588170133588246E0716711
chr3133601946133602097E07120487
chr3133605430133605480E07123971
chr3133606609133606728E07125150
chr3133606737133606971E07125278
chr3133607051133607438E07125592
chr3133611394133611727E07129935
chr3133573215133573347E072-8112
chr3133573885133574171E072-7288
chr3133574725133574824E072-6635
chr3133582298133582380E072839
chr3133584047133584242E0722588
chr3133587242133587401E0725783
chr3133587644133588157E0726185
chr3133588170133588246E0726711
chr3133590458133590539E0728999
chr3133591508133591609E07210049
chr3133596301133596352E07214842
chr3133605430133605480E07223971
chr3133606068133606142E07224609
chr3133606609133606728E07225150
chr3133606737133606971E07225278
chr3133607051133607438E07225592
chr3133540006133540074E073-41385
chr3133540337133540417E073-41042
chr3133540603133541021E073-40438
chr3133541035133541081E073-40378
chr3133541191133541245E073-40214
chr3133572273133572376E073-9083
chr3133573215133573347E073-8112
chr3133573885133574171E073-7288
chr3133574725133574824E073-6635
chr3133575303133575377E073-6082
chr3133584047133584242E0732588
chr3133587242133587401E0735783
chr3133587644133588157E0736185
chr3133588170133588246E0736711
chr3133590458133590539E0738999
chr3133591508133591609E07310049
chr3133606609133606728E07325150
chr3133606737133606971E07325278
chr3133607051133607438E07325592
chr3133540006133540074E074-41385
chr3133540337133540417E074-41042
chr3133540603133541021E074-40438
chr3133541035133541081E074-40378
chr3133541191133541245E074-40214
chr3133541431133541497E074-39962
chr3133541623133541762E074-39697
chr3133541910133541964E074-39495
chr3133572430133572579E074-8880
chr3133572588133572638E074-8821
chr3133573215133573347E074-8112
chr3133573885133574171E074-7288
chr3133574725133574824E074-6635
chr3133587242133587401E0745783
chr3133587644133588157E0746185
chr3133588170133588246E0746711
chr3133599175133599394E07417716
chr3133601479133601597E07420020
chr3133601946133602097E07420487
chr3133606609133606728E07425150
chr3133606737133606971E07425278
chr3133607051133607438E07425592
chr3133611918133612048E07430459
chr3133612068133612226E07430609
chr3133572273133572376E081-9083
chr3133573215133573347E081-8112
chr3133573885133574171E081-7288
chr3133574725133574824E081-6635
chr3133587242133587401E0815783
chr3133588170133588246E0816711
chr3133591508133591609E08110049
chr3133610324133610406E08128865
chr3133610434133610546E08128975
chr3133610595133610710E08129136
chr3133610769133610850E08129310
chr3133610942133611109E08129483
chr3133611135133611246E08129676
chr3133611394133611727E08129935
chr3133611918133612048E08130459
chr3133612068133612226E08130609
chr3133547516133547745E082-33714
chr3133547924133548172E082-33287
chr3133548284133548391E082-33068
chr3133572273133572376E082-9083
chr3133572430133572579E082-8880
chr3133572588133572638E082-8821
chr3133573215133573347E082-8112
chr3133573885133574171E082-7288
chr3133574725133574824E082-6635
chr3133575303133575377E082-6082
chr3133587242133587401E0825783
chr3133587644133588157E0826185
chr3133588170133588246E0826711
chr3133606609133606728E08225150
chr3133606737133606971E08225278
chr3133610324133610406E08228865
chr3133610434133610546E08228975
chr3133610595133610710E08229136
chr3133610769133610850E08229310
chr3133610942133611109E08229483
chr3133611135133611246E08229676
chr3133611394133611727E08229935
chr3133611918133612048E08230459
chr3133612068133612226E08230609










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr3133613212133613784E06731753
chr3133613850133613938E06732391
chr3133614144133615256E06732685
chr3133615513133615575E06734054
chr3133615598133615662E06734139
chr3133613212133613784E06831753
chr3133613850133613938E06832391
chr3133614144133615256E06832685
chr3133615513133615575E06834054
chr3133615598133615662E06834139
chr3133613212133613784E06931753
chr3133613850133613938E06932391
chr3133614144133615256E06932685
chr3133615513133615575E06934054
chr3133615598133615662E06934139
chr3133613212133613784E07031753
chr3133613850133613938E07032391
chr3133614144133615256E07032685
chr3133615513133615575E07034054
chr3133613212133613784E07131753
chr3133613850133613938E07132391
chr3133614144133615256E07132685
chr3133613212133613784E07231753
chr3133613850133613938E07232391
chr3133614144133615256E07232685
chr3133615513133615575E07234054
chr3133615598133615662E07234139
chr3133613212133613784E07331753
chr3133613850133613938E07332391
chr3133614144133615256E07332685
chr3133615513133615575E07334054
chr3133615598133615662E07334139
chr3133613212133613784E07431753
chr3133613850133613938E07432391
chr3133614144133615256E07432685
chr3133613212133613784E08131753
chr3133615513133615575E08134054
chr3133615598133615662E08134139
chr3133613212133613784E08231753
chr3133613850133613938E08232391
chr3133614144133615256E08232685
chr3133615513133615575E08234054
chr3133615598133615662E08234139