rs1882582

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0042 (1280/29976,GnomAD)
A=0055 (1628/29118,TOPMED)
A=0080 (402/5008,1000G)
A=0008 (31/3854,ALSPAC)
A=0008 (29/3708,TWINSUK)

Position: chr12:82681935 (GRCh38.p7) (12q21.31)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 138 Enhancers around

Promoter: 80 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 12	NC_000012.12:g.82681935G>A
GRCh37.p13 chr 12	NC_000012.11:g.83075714G>A

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.908	A=0.092
1000Genomes	American	Sub	694	G=0.870	A=0.130
1000Genomes	East Asian	Sub	1008	G=0.855	A=0.145
1000Genomes	Europe	Sub	1006	G=0.993	A=0.007
1000Genomes	Global	Study-wide	5008	G=0.920	A=0.080
1000Genomes	South Asian	Sub	978	G=0.960	A=0.040
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.992	A=0.008
The Genome Aggregation Database	African	Sub	8720	G=0.915	A=0.085
The Genome Aggregation Database	American	Sub	838	G=0.890	A=0.110
The Genome Aggregation Database	East Asian	Sub	1614	G=0.871	A=0.129
The Genome Aggregation Database	Europe	Sub	18502	G=0.987	A=0.012
The Genome Aggregation Database	Global	Study-wide	29976	G=0.957	A=0.042
The Genome Aggregation Database	Other	Sub	302	G=0.980	A=0.020
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.944	A=0.055
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.992	A=0.008

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

P-Value

SNP ID	p-value	Traits	Study
rs1882582	0.00093	alcohol dependence	20201924

eQTL of rs1882582 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs1882582 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr12	83044267	83045000	E067	-30714
chr12	83084611	83084661	E067	8897
chr12	83084805	83084859	E067	9091
chr12	83084895	83084945	E067	9181
chr12	83085296	83085598	E067	9582
chr12	83085844	83086057	E067	10130
chr12	83086451	83086506	E067	10737
chr12	83092649	83092732	E067	16935
chr12	83101788	83102841	E067	26074
chr12	83044267	83045000	E068	-30714
chr12	83057758	83057933	E068	-17781
chr12	83057947	83058015	E068	-17699
chr12	83075963	83076003	E068	249
chr12	83076067	83076422	E068	353
chr12	83076551	83076950	E068	837
chr12	83085844	83086057	E068	10130
chr12	83086451	83086506	E068	10737
chr12	83089427	83089523	E068	13713
chr12	83089529	83089650	E068	13815
chr12	83089703	83089759	E068	13989
chr12	83100599	83100649	E068	24885
chr12	83100694	83100744	E068	24980
chr12	83100939	83101300	E068	25225
chr12	83101396	83101633	E068	25682
chr12	83101788	83102841	E068	26074
chr12	83102895	83102978	E068	27181
chr12	83115014	83115064	E068	39300
chr12	83044267	83045000	E069	-30714
chr12	83053447	83053645	E069	-22069
chr12	83053686	83053817	E069	-21897
chr12	83075641	83075695	E069	-19
chr12	83075963	83076003	E069	249
chr12	83076067	83076422	E069	353
chr12	83076551	83076950	E069	837
chr12	83084611	83084661	E069	8897
chr12	83084805	83084859	E069	9091
chr12	83084895	83084945	E069	9181
chr12	83092107	83092306	E069	16393
chr12	83092649	83092732	E069	16935
chr12	83092771	83092837	E069	17057
chr12	83101396	83101633	E069	25682
chr12	83101788	83102841	E069	26074
chr12	83102895	83102978	E069	27181
chr12	83103193	83103239	E069	27479
chr12	83103286	83103406	E069	27572
chr12	83103692	83104106	E069	27978
chr12	83114895	83114970	E069	39181
chr12	83115014	83115064	E069	39300
chr12	83075963	83076003	E070	249
chr12	83076067	83076422	E070	353
chr12	83076551	83076950	E070	837
chr12	83084611	83084661	E070	8897
chr12	83084805	83084859	E070	9091
chr12	83084895	83084945	E070	9181
chr12	83085296	83085598	E070	9582
chr12	83085844	83086057	E070	10130
chr12	83086451	83086506	E070	10737
chr12	83101788	83102841	E070	26074
chr12	83041757	83041835	E071	-33879
chr12	83044267	83045000	E071	-30714
chr12	83057758	83057933	E071	-17781
chr12	83057947	83058015	E071	-17699
chr12	83059220	83059363	E071	-16351
chr12	83085844	83086057	E071	10130
chr12	83088814	83089100	E071	13100
chr12	83089427	83089523	E071	13713
chr12	83089529	83089650	E071	13815
chr12	83092107	83092306	E071	16393
chr12	83092649	83092732	E071	16935
chr12	83100939	83101300	E071	25225
chr12	83101396	83101633	E071	25682
chr12	83101788	83102841	E071	26074
chr12	83102895	83102978	E071	27181
chr12	83103193	83103239	E071	27479
chr12	83114895	83114970	E071	39181
chr12	83115014	83115064	E071	39300
chr12	83044267	83045000	E072	-30714
chr12	83053686	83053817	E072	-21897
chr12	83057355	83057405	E072	-18309
chr12	83057758	83057933	E072	-17781
chr12	83057947	83058015	E072	-17699
chr12	83066965	83067196	E072	-8518
chr12	83075963	83076003	E072	249
chr12	83076067	83076422	E072	353
chr12	83076551	83076950	E072	837
chr12	83089427	83089523	E072	13713
chr12	83092107	83092306	E072	16393
chr12	83099426	83099466	E072	23712
chr12	83101396	83101633	E072	25682
chr12	83101788	83102841	E072	26074
chr12	83102895	83102978	E072	27181
chr12	83057758	83057933	E073	-17781
chr12	83057947	83058015	E073	-17699
chr12	83092107	83092306	E073	16393
chr12	83092649	83092732	E073	16935
chr12	83101788	83102841	E073	26074
chr12	83041757	83041835	E074	-33879
chr12	83044267	83045000	E074	-30714
chr12	83053447	83053645	E074	-22069
chr12	83053686	83053817	E074	-21897
chr12	83057758	83057933	E074	-17781
chr12	83058344	83058394	E074	-17320
chr12	83066965	83067196	E074	-8518
chr12	83075963	83076003	E074	249
chr12	83076067	83076422	E074	353
chr12	83076551	83076950	E074	837
chr12	83085844	83086057	E074	10130
chr12	83086451	83086506	E074	10737
chr12	83088814	83089100	E074	13100
chr12	83089427	83089523	E074	13713
chr12	83089529	83089650	E074	13815
chr12	83089703	83089759	E074	13989
chr12	83092107	83092306	E074	16393
chr12	83092649	83092732	E074	16935
chr12	83092771	83092837	E074	17057
chr12	83099426	83099466	E074	23712
chr12	83099686	83099756	E074	23972
chr12	83099823	83099883	E074	24109
chr12	83100599	83100649	E074	24885
chr12	83100694	83100744	E074	24980
chr12	83100939	83101300	E074	25225
chr12	83101396	83101633	E074	25682
chr12	83101788	83102841	E074	26074
chr12	83102895	83102978	E074	27181
chr12	83103193	83103239	E074	27479
chr12	83103286	83103406	E074	27572
chr12	83103692	83104106	E074	27978
chr12	83124643	83125157	E074	48929
chr12	83125206	83125404	E074	49492
chr12	83125506	83125631	E074	49792
chr12	83075641	83075695	E081	-19
chr12	83075963	83076003	E081	249
chr12	83076067	83076422	E081	353
chr12	83085844	83086057	E081	10130
chr12	83076067	83076422	E082	353
chr12	83076551	83076950	E082	837
chr12	83085844	83086057	E082	10130
chr12	83092771	83092837	E082	17057

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr12	83042094	83042312	E067	-33402
chr12	83079312	83082294	E067	3598
chr12	83082295	83082382	E067	6581
chr12	83082454	83082679	E067	6740
chr12	83082690	83082846	E067	6976
chr12	83083192	83083515	E067	7478
chr12	83083636	83083923	E067	7922
chr12	83083956	83084174	E067	8242
chr12	83092881	83093376	E067	17167
chr12	83042094	83042312	E068	-33402
chr12	83079312	83082294	E068	3598
chr12	83082295	83082382	E068	6581
chr12	83082454	83082679	E068	6740
chr12	83082690	83082846	E068	6976
chr12	83083192	83083515	E068	7478
chr12	83083636	83083923	E068	7922
chr12	83083956	83084174	E068	8242
chr12	83092881	83093376	E068	17167
chr12	83042094	83042312	E069	-33402
chr12	83079312	83082294	E069	3598
chr12	83082295	83082382	E069	6581
chr12	83082454	83082679	E069	6740
chr12	83082690	83082846	E069	6976
chr12	83083192	83083515	E069	7478
chr12	83083636	83083923	E069	7922
chr12	83083956	83084174	E069	8242
chr12	83092881	83093376	E069	17167
chr12	83079312	83082294	E070	3598
chr12	83082295	83082382	E070	6581
chr12	83082454	83082679	E070	6740
chr12	83082690	83082846	E070	6976
chr12	83083192	83083515	E070	7478
chr12	83083636	83083923	E070	7922
chr12	83083956	83084174	E070	8242
chr12	83092881	83093376	E070	17167
chr12	83042094	83042312	E071	-33402
chr12	83079312	83082294	E071	3598
chr12	83082295	83082382	E071	6581
chr12	83082454	83082679	E071	6740
chr12	83082690	83082846	E071	6976
chr12	83083192	83083515	E071	7478
chr12	83083636	83083923	E071	7922
chr12	83083956	83084174	E071	8242
chr12	83092881	83093376	E071	17167
chr12	83042094	83042312	E072	-33402
chr12	83079312	83082294	E072	3598
chr12	83082295	83082382	E072	6581
chr12	83082454	83082679	E072	6740
chr12	83082690	83082846	E072	6976
chr12	83083192	83083515	E072	7478
chr12	83083636	83083923	E072	7922
chr12	83083956	83084174	E072	8242
chr12	83092881	83093376	E072	17167
chr12	83079312	83082294	E073	3598
chr12	83082295	83082382	E073	6581
chr12	83082454	83082679	E073	6740
chr12	83082690	83082846	E073	6976
chr12	83083192	83083515	E073	7478
chr12	83083636	83083923	E073	7922
chr12	83083956	83084174	E073	8242
chr12	83092881	83093376	E073	17167
chr12	83079312	83082294	E074	3598
chr12	83082295	83082382	E074	6581
chr12	83082454	83082679	E074	6740
chr12	83082690	83082846	E074	6976
chr12	83083192	83083515	E074	7478
chr12	83083636	83083923	E074	7922
chr12	83083956	83084174	E074	8242
chr12	83092881	83093376	E074	17167
chr12	83079312	83082294	E081	3598
chr12	83082295	83082382	E081	6581
chr12	83082454	83082679	E081	6740
chr12	83082690	83082846	E081	6976
chr12	83079312	83082294	E082	3598
chr12	83082295	83082382	E082	6581
chr12	83082454	83082679	E082	6740
chr12	83082690	83082846	E082	6976
chr12	83083192	83083515	E082	7478
chr12	83083636	83083923	E082	7922
chr12	83083956	83084174	E082	8242