SNP Detail Info-rs1898198

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

ASAH2 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0340 (10189/29890,GnomAD)
G=0289 (8433/29118,TOPMED)
G=0271 (1355/5008,1000G)
G=0469 (1807/3854,ALSPAC)
G=0469 (1738/3708,TWINSUK)

Position: chr10:50249888 (GRCh38.p7) (10q11.23)

Phenotype: OD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 10 Enhancers around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 10	NC_000010.11:g.50249888A>G
GRCh37.p13 chr 10	NC_000010.10:g.52009648A>G

Molecule type	Change	Amino acid[Codon]	SO Term
ASAH2 transcript variant 2	NM_001143974.1:c.	N/A	Genic Upstream Transcript Variant
ASAH2 transcript variant 1	NM_019893.2:c.	N/A	Genic Upstream Transcript Variant
ASAH2 transcript variant X1	XM_011539970.2:c.	N/A	Intron Variant
ASAH2 transcript variant X3	XM_011539971.2:c.	N/A	Intron Variant
ASAH2 transcript variant X4	XM_011539972.2:c.	N/A	Intron Variant
ASAH2 transcript variant X5	XM_011539973.2:c.	N/A	Intron Variant
ASAH2 transcript variant X2	XM_017016435.1:c.	N/A	Intron Variant
ASAH2 transcript variant X7	XM_017016436.1:c.	N/A	Genic Upstream Transcript Variant
ASAH2 transcript variant X6	XR_945787.2:n.	N/A	Intron Variant

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.970	G=0.030
1000Genomes	American	Sub	694	A=0.580	G=0.420
1000Genomes	East Asian	Sub	1008	A=0.696	G=0.304
1000Genomes	Europe	Sub	1006	A=0.521	G=0.479
1000Genomes	Global	Study-wide	5008	A=0.729	G=0.271
1000Genomes	South Asian	Sub	978	A=0.760	G=0.240
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.531	G=0.469
The Genome Aggregation Database	African	Sub	8712	A=0.902	G=0.098
The Genome Aggregation Database	American	Sub	838	A=0.600	G=0.400
The Genome Aggregation Database	East Asian	Sub	1610	A=0.691	G=0.309
The Genome Aggregation Database	Europe	Sub	18428	A=0.544	G=0.455
The Genome Aggregation Database	Global	Study-wide	29890	A=0.659	G=0.340
The Genome Aggregation Database	Other	Sub	302	A=0.640	G=0.360
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.710	G=0.289
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.531	G=0.469

PMID	Title	Author	Journal
23183491	Genome-wide association study identifies a potent locus associated with human opioid sensitivity.	Nishizawa D	Mol Psychiatry

SNP ID	p-value	Traits	Study
rs1898198	1.28E-05	Opioid sensitivity	23183491

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr10	52045948	52047526	E068	36300
chr10	52045948	52047526	E069	36300
chr10	52045948	52047526	E071	36300
chr10	52045948	52047526	E072	36300
chr10	52051407	52051561	E074	41759
chr10	52045711	52045761	E081	36063
chr10	52045948	52047526	E081	36300
chr10	52047621	52047698	E081	37973
chr10	52047730	52047795	E081	38082
chr10	52047796	52047872	E081	38148

rs1898198