rs1918392

Homo sapiens
A>G
LOC105377167 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0133 (3986/29968,GnomAD)
A==0110 (3210/29118,TOPMED)
A==0140 (699/5008,1000G)
A==0179 (689/3854,ALSPAC)
A==0166 (614/3708,TWINSUK)
chr3:74831706 (GRCh38.p7) (3p12.3)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.74831706A>G
GRCh37.p13 chr 3NC_000003.11:g.74880857A>G

Gene: LOC105377167, uncharacterized LOC105377167(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105377167 transcript variant X4XR_001740758.1:n.N/AIntron Variant
LOC105377167 transcript variant X1XR_940970.2:n.N/AIntron Variant
LOC105377167 transcript variant X3XR_940972.2:n.N/AIntron Variant
LOC105377167 transcript variant X2XR_940971.1:n.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.016G=0.984
1000GenomesAmericanSub694A=0.140G=0.860
1000GenomesEast AsianSub1008A=0.274G=0.726
1000GenomesEuropeSub1006A=0.162G=0.838
1000GenomesGlobalStudy-wide5008A=0.140G=0.860
1000GenomesSouth AsianSub978A=0.150G=0.850
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.179G=0.821
The Genome Aggregation DatabaseAfricanSub8728A=0.036G=0.964
The Genome Aggregation DatabaseAmericanSub836A=0.140G=0.860
The Genome Aggregation DatabaseEast AsianSub1618A=0.270G=0.730
The Genome Aggregation DatabaseEuropeSub18486A=0.165G=0.834
The Genome Aggregation DatabaseGlobalStudy-wide29968A=0.133G=0.867
The Genome Aggregation DatabaseOtherSub300A=0.210G=0.790
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.110G=0.889
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.166G=0.834
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs19183920.000522alcohol dependence20201924

eQTL of rs1918392 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1918392 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr37483620874836566E070-44291
chr37483676374836844E070-44013
chr37489760674897665E07016749
chr37489771374897763E07016856
chr37483620874836566E081-44291
chr37483676374836844E081-44013
chr37486190974862266E081-18591
chr37486453974864589E081-16268
chr37490673274906857E08125875
chr37490698874907142E08126131
chr37490730774907560E08126450
chr37490766074907824E08126803
chr37490819274908343E08127335
chr37491133374911489E08130476
chr37491179074911914E08130933
chr37491353974913589E08132682
chr37483620874836566E082-44291
chr37483676374836844E082-44013
chr37490819274908343E08227335
chr37491055074910610E08229693
chr37491114274911192E08230285
chr37491133374911489E08230476
chr37491179074911914E08230933
chr37491538874916366E08234531