rs1933734

Organism: Homo sapiens

Alleles: T>C

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

C=0484 (14473/29886,GnomAD)
C=0492 (14327/29118,TOPMED)
C=0369 (1849/5008,1000G)
C=0472 (1819/3854,ALSPAC)
C=0484 (1795/3708,TWINSUK)

Position: chr1:9842070 (GRCh38.p7) (1p36.22)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 446 Enhancers around

Promoter: 9 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 1	NC_000001.11:g.9842070T>C
GRCh37.p13 chr 1	NC_000001.10:g.9902128T>C

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	T=0.491	C=0.509
1000Genomes	American	Sub	694	T=0.560	C=0.440
1000Genomes	East Asian	Sub	1008	T=0.874	C=0.126
1000Genomes	Europe	Sub	1006	T=0.508	C=0.492
1000Genomes	Global	Study-wide	5008	T=0.631	C=0.369
1000Genomes	South Asian	Sub	978	T=0.750	C=0.250
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	T=0.528	C=0.472
The Genome Aggregation Database	African	Sub	8694	T=0.461	C=0.539
The Genome Aggregation Database	American	Sub	838	T=0.570	C=0.430
The Genome Aggregation Database	East Asian	Sub	1612	T=0.867	C=0.133
The Genome Aggregation Database	Europe	Sub	18440	T=0.507	C=0.492
The Genome Aggregation Database	Global	Study-wide	29886	T=0.515	C=0.484
The Genome Aggregation Database	Other	Sub	302	T=0.550	C=0.450
Trans-Omics for Precision Medicine	Global	Study-wide	29118	T=0.508	C=0.492
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	T=0.516	C=0.484

PMID	Title	Author	Journal
24277619	ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.	Quillen EE	Am J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID	p-value	Traits	Study
rs1933734	0.000936	alcohol consumption (maxi-drinks)	24277619

eQTL of rs1933734 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs1933734 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr1	9852188	9852238	E067	-49890
chr1	9852336	9852957	E067	-49171
chr1	9853484	9853534	E067	-48594
chr1	9853581	9853668	E067	-48460
chr1	9853781	9853861	E067	-48267
chr1	9853941	9854065	E067	-48063
chr1	9854128	9854241	E067	-47887
chr1	9854672	9854755	E067	-47373
chr1	9854903	9855082	E067	-47046
chr1	9858333	9858822	E067	-43306
chr1	9858969	9859046	E067	-43082
chr1	9867664	9867933	E067	-34195
chr1	9868132	9868199	E067	-33929
chr1	9868380	9868424	E067	-33704
chr1	9868612	9868760	E067	-33368
chr1	9868995	9869106	E067	-33022
chr1	9869112	9869579	E067	-32549
chr1	9871232	9871276	E067	-30852
chr1	9871469	9871673	E067	-30455
chr1	9872250	9872318	E067	-29810
chr1	9875610	9875696	E067	-26432
chr1	9876322	9876527	E067	-25601
chr1	9877137	9877192	E067	-24936
chr1	9895531	9895683	E067	-6445
chr1	9895685	9897072	E067	-5056
chr1	9900170	9900821	E067	-1307
chr1	9902185	9902535	E067	57
chr1	9902624	9902716	E067	496
chr1	9902845	9902940	E067	717
chr1	9902963	9903224	E067	835
chr1	9903552	9904093	E067	1424
chr1	9904306	9904395	E067	2178
chr1	9904609	9904649	E067	2481
chr1	9907132	9907202	E067	5004
chr1	9907409	9907459	E067	5281
chr1	9912352	9912450	E067	10224
chr1	9912513	9912833	E067	10385
chr1	9912846	9912944	E067	10718
chr1	9913092	9913178	E067	10964
chr1	9913264	9913324	E067	11136
chr1	9913492	9913573	E067	11364
chr1	9935763	9935879	E067	33635
chr1	9936942	9937152	E067	34814
chr1	9937232	9937397	E067	35104
chr1	9937478	9937563	E067	35350
chr1	9944229	9944287	E067	42101
chr1	9944352	9944589	E067	42224
chr1	9944644	9944727	E067	42516
chr1	9946202	9946634	E067	44074
chr1	9950054	9950129	E067	47926
chr1	9950176	9951650	E067	48048
chr1	9852188	9852238	E068	-49890
chr1	9852336	9852957	E068	-49171
chr1	9853484	9853534	E068	-48594
chr1	9853581	9853668	E068	-48460
chr1	9853781	9853861	E068	-48267
chr1	9853941	9854065	E068	-48063
chr1	9854128	9854241	E068	-47887
chr1	9856811	9857231	E068	-44897
chr1	9858333	9858822	E068	-43306
chr1	9858969	9859046	E068	-43082
chr1	9864463	9864910	E068	-37218
chr1	9864913	9865266	E068	-36862
chr1	9867322	9867362	E068	-34766
chr1	9867396	9867460	E068	-34668
chr1	9867664	9867933	E068	-34195
chr1	9868132	9868199	E068	-33929
chr1	9868380	9868424	E068	-33704
chr1	9868612	9868760	E068	-33368
chr1	9868995	9869106	E068	-33022
chr1	9869112	9869579	E068	-32549
chr1	9871469	9871673	E068	-30455
chr1	9872250	9872318	E068	-29810
chr1	9884909	9886221	E068	-15907
chr1	9895531	9895683	E068	-6445
chr1	9895685	9897072	E068	-5056
chr1	9902624	9902716	E068	496
chr1	9902845	9902940	E068	717
chr1	9902963	9903224	E068	835
chr1	9903552	9904093	E068	1424
chr1	9904306	9904395	E068	2178
chr1	9904609	9904649	E068	2481
chr1	9906105	9906258	E068	3977
chr1	9907409	9907459	E068	5281
chr1	9912352	9912450	E068	10224
chr1	9912513	9912833	E068	10385
chr1	9912846	9912944	E068	10718
chr1	9913092	9913178	E068	10964
chr1	9919425	9919886	E068	17297
chr1	9923630	9923741	E068	21502
chr1	9936942	9937152	E068	34814
chr1	9937232	9937397	E068	35104
chr1	9944229	9944287	E068	42101
chr1	9944352	9944589	E068	42224
chr1	9944644	9944727	E068	42516
chr1	9950054	9950129	E068	47926
chr1	9950176	9951650	E068	48048
chr1	9852188	9852238	E069	-49890
chr1	9852336	9852957	E069	-49171
chr1	9853484	9853534	E069	-48594
chr1	9853581	9853668	E069	-48460
chr1	9853781	9853861	E069	-48267
chr1	9853941	9854065	E069	-48063
chr1	9854128	9854241	E069	-47887
chr1	9854672	9854755	E069	-47373
chr1	9858333	9858822	E069	-43306
chr1	9858969	9859046	E069	-43082
chr1	9884909	9886221	E069	-15907
chr1	9895531	9895683	E069	-6445
chr1	9895685	9897072	E069	-5056
chr1	9900170	9900821	E069	-1307
chr1	9902185	9902535	E069	57
chr1	9902624	9902716	E069	496
chr1	9902845	9902940	E069	717
chr1	9902963	9903224	E069	835
chr1	9903552	9904093	E069	1424
chr1	9904306	9904395	E069	2178
chr1	9906105	9906258	E069	3977
chr1	9912352	9912450	E069	10224
chr1	9912513	9912833	E069	10385
chr1	9912846	9912944	E069	10718
chr1	9913092	9913178	E069	10964
chr1	9923630	9923741	E069	21502
chr1	9927466	9928005	E069	25338
chr1	9934802	9935569	E069	32674
chr1	9935763	9935879	E069	33635
chr1	9936942	9937152	E069	34814
chr1	9937232	9937397	E069	35104
chr1	9937478	9937563	E069	35350
chr1	9944229	9944287	E069	42101
chr1	9944352	9944589	E069	42224
chr1	9944644	9944727	E069	42516
chr1	9946202	9946634	E069	44074
chr1	9946846	9946900	E069	44718
chr1	9946993	9947189	E069	44865
chr1	9950054	9950129	E069	47926
chr1	9950176	9951650	E069	48048
chr1	9852336	9852957	E070	-49171
chr1	9853484	9853534	E070	-48594
chr1	9853581	9853668	E070	-48460
chr1	9853781	9853861	E070	-48267
chr1	9853941	9854065	E070	-48063
chr1	9871469	9871673	E070	-30455
chr1	9880680	9880853	E070	-21275
chr1	9881626	9881666	E070	-20462
chr1	9884909	9886221	E070	-15907
chr1	9897673	9897867	E070	-4261
chr1	9900170	9900821	E070	-1307
chr1	9902185	9902535	E070	57
chr1	9902624	9902716	E070	496
chr1	9902845	9902940	E070	717
chr1	9902963	9903224	E070	835
chr1	9903552	9904093	E070	1424
chr1	9904306	9904395	E070	2178
chr1	9912352	9912450	E070	10224
chr1	9912513	9912833	E070	10385
chr1	9912846	9912944	E070	10718
chr1	9935763	9935879	E070	33635
chr1	9936942	9937152	E070	34814
chr1	9937232	9937397	E070	35104
chr1	9937478	9937563	E070	35350
chr1	9852188	9852238	E071	-49890
chr1	9852336	9852957	E071	-49171
chr1	9853484	9853534	E071	-48594
chr1	9853581	9853668	E071	-48460
chr1	9853781	9853861	E071	-48267
chr1	9853941	9854065	E071	-48063
chr1	9854128	9854241	E071	-47887
chr1	9854672	9854755	E071	-47373
chr1	9856811	9857231	E071	-44897
chr1	9857574	9857673	E071	-44455
chr1	9857715	9857765	E071	-44363
chr1	9858191	9858237	E071	-43891
chr1	9858333	9858822	E071	-43306
chr1	9858969	9859046	E071	-43082
chr1	9868132	9868199	E071	-33929
chr1	9868380	9868424	E071	-33704
chr1	9868612	9868760	E071	-33368
chr1	9868995	9869106	E071	-33022
chr1	9869112	9869579	E071	-32549
chr1	9870939	9871084	E071	-31044
chr1	9871232	9871276	E071	-30852
chr1	9871469	9871673	E071	-30455
chr1	9872250	9872318	E071	-29810
chr1	9875061	9875171	E071	-26957
chr1	9875199	9875526	E071	-26602
chr1	9881626	9881666	E071	-20462
chr1	9881867	9882125	E071	-20003
chr1	9884909	9886221	E071	-15907
chr1	9895531	9895683	E071	-6445
chr1	9895685	9897072	E071	-5056
chr1	9900170	9900821	E071	-1307
chr1	9902624	9902716	E071	496
chr1	9902845	9902940	E071	717
chr1	9902963	9903224	E071	835
chr1	9903552	9904093	E071	1424
chr1	9906105	9906258	E071	3977
chr1	9907132	9907202	E071	5004
chr1	9907409	9907459	E071	5281
chr1	9912352	9912450	E071	10224
chr1	9912513	9912833	E071	10385
chr1	9912846	9912944	E071	10718
chr1	9913092	9913178	E071	10964
chr1	9913264	9913324	E071	11136
chr1	9913492	9913573	E071	11364
chr1	9919425	9919886	E071	17297
chr1	9923630	9923741	E071	21502
chr1	9930745	9930895	E071	28617
chr1	9934802	9935569	E071	32674
chr1	9937232	9937397	E071	35104
chr1	9937478	9937563	E071	35350
chr1	9944229	9944287	E071	42101
chr1	9944352	9944589	E071	42224
chr1	9944644	9944727	E071	42516
chr1	9946202	9946634	E071	44074
chr1	9950054	9950129	E071	47926
chr1	9950176	9951650	E071	48048
chr1	9852188	9852238	E072	-49890
chr1	9852336	9852957	E072	-49171
chr1	9853484	9853534	E072	-48594
chr1	9853581	9853668	E072	-48460
chr1	9853781	9853861	E072	-48267
chr1	9853941	9854065	E072	-48063
chr1	9854128	9854241	E072	-47887
chr1	9854672	9854755	E072	-47373
chr1	9856811	9857231	E072	-44897
chr1	9858333	9858822	E072	-43306
chr1	9868380	9868424	E072	-33704
chr1	9868612	9868760	E072	-33368
chr1	9868995	9869106	E072	-33022
chr1	9869112	9869579	E072	-32549
chr1	9870939	9871084	E072	-31044
chr1	9871232	9871276	E072	-30852
chr1	9871469	9871673	E072	-30455
chr1	9872250	9872318	E072	-29810
chr1	9884909	9886221	E072	-15907
chr1	9895531	9895683	E072	-6445
chr1	9895685	9897072	E072	-5056
chr1	9900170	9900821	E072	-1307
chr1	9902624	9902716	E072	496
chr1	9902845	9902940	E072	717
chr1	9902963	9903224	E072	835
chr1	9903552	9904093	E072	1424
chr1	9904306	9904395	E072	2178
chr1	9904609	9904649	E072	2481
chr1	9905268	9905344	E072	3140
chr1	9905933	9905998	E072	3805
chr1	9906105	9906258	E072	3977
chr1	9906904	9906954	E072	4776
chr1	9908584	9908707	E072	6456
chr1	9908796	9908865	E072	6668
chr1	9912352	9912450	E072	10224
chr1	9912513	9912833	E072	10385
chr1	9912846	9912944	E072	10718
chr1	9913092	9913178	E072	10964
chr1	9913264	9913324	E072	11136
chr1	9913492	9913573	E072	11364
chr1	9923630	9923741	E072	21502
chr1	9927466	9928005	E072	25338
chr1	9932886	9933060	E072	30758
chr1	9933076	9933222	E072	30948
chr1	9933292	9933385	E072	31164
chr1	9934170	9934383	E072	32042
chr1	9934527	9934577	E072	32399
chr1	9934802	9935569	E072	32674
chr1	9936942	9937152	E072	34814
chr1	9937232	9937397	E072	35104
chr1	9937478	9937563	E072	35350
chr1	9944229	9944287	E072	42101
chr1	9944352	9944589	E072	42224
chr1	9944644	9944727	E072	42516
chr1	9950054	9950129	E072	47926
chr1	9950176	9951650	E072	48048
chr1	9852188	9852238	E073	-49890
chr1	9852336	9852957	E073	-49171
chr1	9853484	9853534	E073	-48594
chr1	9853581	9853668	E073	-48460
chr1	9853781	9853861	E073	-48267
chr1	9853941	9854065	E073	-48063
chr1	9854128	9854241	E073	-47887
chr1	9856811	9857231	E073	-44897
chr1	9857574	9857673	E073	-44455
chr1	9857715	9857765	E073	-44363
chr1	9858191	9858237	E073	-43891
chr1	9858333	9858822	E073	-43306
chr1	9867117	9867301	E073	-34827
chr1	9867664	9867933	E073	-34195
chr1	9868612	9868760	E073	-33368
chr1	9868995	9869106	E073	-33022
chr1	9869112	9869579	E073	-32549
chr1	9884909	9886221	E073	-15907
chr1	9895531	9895683	E073	-6445
chr1	9895685	9897072	E073	-5056
chr1	9902185	9902535	E073	57
chr1	9902624	9902716	E073	496
chr1	9902845	9902940	E073	717
chr1	9902963	9903224	E073	835
chr1	9903552	9904093	E073	1424
chr1	9904306	9904395	E073	2178
chr1	9904609	9904649	E073	2481
chr1	9905268	9905344	E073	3140
chr1	9905933	9905998	E073	3805
chr1	9906105	9906258	E073	3977
chr1	9906904	9906954	E073	4776
chr1	9907132	9907202	E073	5004
chr1	9907409	9907459	E073	5281
chr1	9908438	9908488	E073	6310
chr1	9908584	9908707	E073	6456
chr1	9908796	9908865	E073	6668
chr1	9912352	9912450	E073	10224
chr1	9912513	9912833	E073	10385
chr1	9912846	9912944	E073	10718
chr1	9913092	9913178	E073	10964
chr1	9913264	9913324	E073	11136
chr1	9913492	9913573	E073	11364
chr1	9919425	9919886	E073	17297
chr1	9922760	9922810	E073	20632
chr1	9923044	9923281	E073	20916
chr1	9923630	9923741	E073	21502
chr1	9927466	9928005	E073	25338
chr1	9934802	9935569	E073	32674
chr1	9935763	9935879	E073	33635
chr1	9936942	9937152	E073	34814
chr1	9937232	9937397	E073	35104
chr1	9937478	9937563	E073	35350
chr1	9944229	9944287	E073	42101
chr1	9944352	9944589	E073	42224
chr1	9944644	9944727	E073	42516
chr1	9950054	9950129	E073	47926
chr1	9950176	9951650	E073	48048
chr1	9852188	9852238	E074	-49890
chr1	9852336	9852957	E074	-49171
chr1	9853484	9853534	E074	-48594
chr1	9853581	9853668	E074	-48460
chr1	9853781	9853861	E074	-48267
chr1	9853941	9854065	E074	-48063
chr1	9854128	9854241	E074	-47887
chr1	9858333	9858822	E074	-43306
chr1	9868995	9869106	E074	-33022
chr1	9869112	9869579	E074	-32549
chr1	9871232	9871276	E074	-30852
chr1	9871469	9871673	E074	-30455
chr1	9872250	9872318	E074	-29810
chr1	9881867	9882125	E074	-20003
chr1	9884909	9886221	E074	-15907
chr1	9895531	9895683	E074	-6445
chr1	9900170	9900821	E074	-1307
chr1	9903552	9904093	E074	1424
chr1	9906105	9906258	E074	3977
chr1	9906904	9906954	E074	4776
chr1	9912352	9912450	E074	10224
chr1	9912513	9912833	E074	10385
chr1	9912846	9912944	E074	10718
chr1	9913092	9913178	E074	10964
chr1	9913264	9913324	E074	11136
chr1	9919425	9919886	E074	17297
chr1	9936942	9937152	E074	34814
chr1	9937232	9937397	E074	35104
chr1	9937478	9937563	E074	35350
chr1	9944229	9944287	E074	42101
chr1	9944352	9944589	E074	42224
chr1	9944644	9944727	E074	42516
chr1	9946202	9946634	E074	44074
chr1	9950054	9950129	E074	47926
chr1	9950176	9951650	E074	48048
chr1	9852188	9852238	E081	-49890
chr1	9852336	9852957	E081	-49171
chr1	9853484	9853534	E081	-48594
chr1	9853581	9853668	E081	-48460
chr1	9853781	9853861	E081	-48267
chr1	9853941	9854065	E081	-48063
chr1	9854128	9854241	E081	-47887
chr1	9854672	9854755	E081	-47373
chr1	9856811	9857231	E081	-44897
chr1	9857574	9857673	E081	-44455
chr1	9857715	9857765	E081	-44363
chr1	9858191	9858237	E081	-43891
chr1	9858333	9858822	E081	-43306
chr1	9858969	9859046	E081	-43082
chr1	9870939	9871084	E081	-31044
chr1	9871232	9871276	E081	-30852
chr1	9871469	9871673	E081	-30455
chr1	9872250	9872318	E081	-29810
chr1	9880680	9880853	E081	-21275
chr1	9881626	9881666	E081	-20462
chr1	9895531	9895683	E081	-6445
chr1	9895685	9897072	E081	-5056
chr1	9900170	9900821	E081	-1307
chr1	9902185	9902535	E081	57
chr1	9902624	9902716	E081	496
chr1	9902845	9902940	E081	717
chr1	9902963	9903224	E081	835
chr1	9903552	9904093	E081	1424
chr1	9904306	9904395	E081	2178
chr1	9904609	9904649	E081	2481
chr1	9912352	9912450	E081	10224
chr1	9912513	9912833	E081	10385
chr1	9912846	9912944	E081	10718
chr1	9913092	9913178	E081	10964
chr1	9913264	9913324	E081	11136
chr1	9927466	9928005	E081	25338
chr1	9932886	9933060	E081	30758
chr1	9933076	9933222	E081	30948
chr1	9933292	9933385	E081	31164
chr1	9934802	9935569	E081	32674
chr1	9935763	9935879	E081	33635
chr1	9936942	9937152	E081	34814
chr1	9950054	9950129	E081	47926
chr1	9852188	9852238	E082	-49890
chr1	9852336	9852957	E082	-49171
chr1	9853781	9853861	E082	-48267
chr1	9853941	9854065	E082	-48063
chr1	9854128	9854241	E082	-47887
chr1	9856811	9857231	E082	-44897
chr1	9857574	9857673	E082	-44455
chr1	9857715	9857765	E082	-44363
chr1	9858191	9858237	E082	-43891
chr1	9858333	9858822	E082	-43306
chr1	9858969	9859046	E082	-43082
chr1	9870939	9871084	E082	-31044
chr1	9871232	9871276	E082	-30852
chr1	9871469	9871673	E082	-30455
chr1	9880680	9880853	E082	-21275
chr1	9881626	9881666	E082	-20462
chr1	9895531	9895683	E082	-6445
chr1	9895685	9897072	E082	-5056
chr1	9902624	9902716	E082	496
chr1	9902845	9902940	E082	717
chr1	9902963	9903224	E082	835
chr1	9903552	9904093	E082	1424
chr1	9904306	9904395	E082	2178
chr1	9904609	9904649	E082	2481
chr1	9912352	9912450	E082	10224
chr1	9912513	9912833	E082	10385
chr1	9912846	9912944	E082	10718
chr1	9913092	9913178	E082	10964
chr1	9913264	9913324	E082	11136
chr1	9913492	9913573	E082	11364
chr1	9932886	9933060	E082	30758
chr1	9933076	9933222	E082	30948
chr1	9933292	9933385	E082	31164
chr1	9933592	9933917	E082	31464
chr1	9934170	9934383	E082	32042
chr1	9934802	9935569	E082	32674
chr1	9935763	9935879	E082	33635
chr1	9950054	9950129	E082	47926

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr1	9882896	9884891	E067	-17237
chr1	9882896	9884891	E068	-17237
chr1	9882896	9884891	E069	-17237
chr1	9882896	9884891	E070	-17237
chr1	9882896	9884891	E071	-17237
chr1	9882896	9884891	E072	-17237
chr1	9882896	9884891	E073	-17237
chr1	9882896	9884891	E074	-17237
chr1	9882896	9884891	E082	-17237