SNP Detail Info-rs1937970

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 10	NC_000010.11:g.82463710A>G
GRCh37.p13 chr 10	NC_000010.10:g.84223466A>G
NRG3 RefSeqGene	NG_013373.1:g.593397A>G

Gene: NRG3, neuregulin 3(plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
NRG3 transcript variant 1	NM_001010848.3:c.	N/A	Intron Variant
NRG3 transcript variant 2	NM_001165972.1:c.	N/A	Intron Variant
NRG3 transcript variant 3	NM_001165973.1:c.	N/A	Intron Variant
NRG3 transcript variant X10	XM_005269444.4:c.	N/A	Intron Variant
NRG3 transcript variant X8	XM_011539172.2:c.	N/A	Intron Variant
NRG3 transcript variant X11	XM_011539173.2:c.	N/A	Intron Variant
NRG3 transcript variant X12	XM_011539175.2:c.	N/A	Intron Variant
NRG3 transcript variant X1	XM_017015573.1:c.	N/A	Intron Variant
NRG3 transcript variant X2	XM_017015574.1:c.	N/A	Intron Variant
NRG3 transcript variant X3	XM_017015575.1:c.	N/A	Intron Variant
NRG3 transcript variant X4	XM_017015576.1:c.	N/A	Intron Variant
NRG3 transcript variant X5	XM_017015577.1:c.	N/A	Intron Variant
NRG3 transcript variant X6	XM_017015578.1:c.	N/A	Intron Variant
NRG3 transcript variant X7	XM_017015579.1:c.	N/A	Intron Variant
NRG3 transcript variant X9	XM_017015580.1:c.	N/A	Intron Variant
NRG3 transcript variant X13	XM_017015581.1:c.	N/A	Intron Variant
NRG3 transcript variant X15	XM_017015582.1:c.	N/A	Intron Variant
NRG3 transcript variant X16	XM_017015583.1:c.	N/A	Intron Variant
NRG3 transcript variant X17	XM_017015584.1:c.	N/A	Intron Variant
NRG3 transcript variant X18	XM_011539178.2:c.	N/A	Genic Upstream Transcript Variant
NRG3 transcript variant X14	XR_001747009.1:n.	N/A	Intron Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.126	G=0.874
1000Genomes	American	Sub	694	A=0.490	G=0.510
1000Genomes	East Asian	Sub	1008	A=0.405	G=0.595
1000Genomes	Europe	Sub	1006	A=0.713	G=0.287
1000Genomes	Global	Study-wide	5008	A=0.474	G=0.526
1000Genomes	South Asian	Sub	978	A=0.750	G=0.250
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.701	G=0.299
The Genome Aggregation Database	African	Sub	8710	A=0.214	G=0.786
The Genome Aggregation Database	American	Sub	834	A=0.500	G=0.500
The Genome Aggregation Database	East Asian	Sub	1618	A=0.415	G=0.585
The Genome Aggregation Database	Europe	Sub	18476	A=0.703	G=0.297
The Genome Aggregation Database	Global	Study-wide	29940	A=0.540	G=0.459
The Genome Aggregation Database	Other	Sub	302	A=0.770	G=0.230
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.474	G=0.525
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.709	G=0.291

PMID	Title	Author	Journal
20713722	Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain.	Kao WT	Proc Natl Acad Sci U S A
21546496	Novel loci involved in platelet function and platelet count identified by a genome-wide study performed in children.	Guerrero JA	Haematologica
19118813	Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia.	Chen PL	Am J Hum Genet
24277619	ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.	Quillen EE	Am J Med Genet B Neuropsychiatr Genet
18708184	Neuregulin 3 genetic variations and susceptibility to schizophrenia in a Chinese population.	Wang YC	Biol Psychiatry

P-Value

SNP ID	p-value	Traits	Study
rs1937970	0.000737	alcohol dependence	24277619

eQTL of rs1937970 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs1937970 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr10	84174915	84175228	E070	-48238
chr10	84175462	84175546	E070	-47920
chr10	84179829	84180109	E070	-43357
chr10	84180205	84180274	E070	-43192
chr10	84180371	84180425	E070	-43041
chr10	84180676	84180835	E070	-42631
chr10	84180996	84181200	E070	-42266
chr10	84222790	84223373	E070	-93
chr10	84223442	84223544	E070	0
chr10	84223590	84223672	E070	124
chr10	84223964	84224283	E070	498
chr10	84224320	84224484	E070	854
chr10	84224488	84224770	E070	1022
chr10	84224835	84225256	E070	1369
chr10	84225363	84225416	E070	1897
chr10	84225897	84225947	E070	2431
chr10	84232706	84232777	E070	9240
chr10	84232791	84232995	E070	9325
chr10	84223964	84224283	E071	498
chr10	84224320	84224484	E071	854
chr10	84224488	84224770	E071	1022
chr10	84223442	84223544	E072	0
chr10	84223590	84223672	E072	124
chr10	84223964	84224283	E072	498
chr10	84224835	84225256	E073	1369
chr10	84225363	84225416	E073	1897
chr10	84179625	84179700	E081	-43766
chr10	84179829	84180109	E081	-43357
chr10	84180205	84180274	E081	-43192
chr10	84180371	84180425	E081	-43041
chr10	84180676	84180835	E081	-42631
chr10	84180996	84181200	E081	-42266
chr10	84181256	84181330	E081	-42136
chr10	84211871	84212112	E081	-11354
chr10	84223964	84224283	E081	498
chr10	84224320	84224484	E081	854
chr10	84224488	84224770	E081	1022
chr10	84224835	84225256	E081	1369
chr10	84225363	84225416	E081	1897
chr10	84179829	84180109	E082	-43357
chr10	84180205	84180274	E082	-43192
chr10	84180371	84180425	E082	-43041
chr10	84180676	84180835	E082	-42631
chr10	84180996	84181200	E082	-42266
chr10	84181256	84181330	E082	-42136
chr10	84222790	84223373	E082	-93
chr10	84223442	84223544	E082	0
chr10	84223590	84223672	E082	124
chr10	84223964	84224283	E082	498
chr10	84224320	84224484	E082	854
chr10	84224488	84224770	E082	1022
chr10	84224835	84225256	E082	1369
chr10	84225363	84225416	E082	1897

rs1937970

Genomic Coordinates

Gene: NRG3, neuregulin 3(plus strand)

Population Frequency

P-Value

eQTL of rs1937970 in Brain tissues (GTEx Analysis Release V7)

meQTL of rs1937970 in Fetal Brain

Genomic View

Chromatin Interaction

Enhancer Annotation (GRCh37.p13)