rs1955185

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
C==0361 (10800/29918,GnomAD)
C==0439 (12807/29118,TOPMED)
C==0381 (1907/5008,1000G)
C==0224 (863/3854,ALSPAC)
C==0232 (862/3708,TWINSUK)
chr8:42694504 (GRCh38.p7) (8p11.21)
ND
GWASdb2
7   publication(s)
See rs on genome
28 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.42694504C>T
GRCh37.p13 chr 8NC_000008.10:g.42549647C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.753T=0.247
1000GenomesAmericanSub694C=0.300T=0.700
1000GenomesEast AsianSub1008C=0.205T=0.795
1000GenomesEuropeSub1006C=0.224T=0.776
1000GenomesGlobalStudy-wide5008C=0.381T=0.619
1000GenomesSouth AsianSub978C=0.270T=0.730
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.224T=0.776
The Genome Aggregation DatabaseAfricanSub8684C=0.694T=0.306
The Genome Aggregation DatabaseAmericanSub834C=0.240T=0.760
The Genome Aggregation DatabaseEast AsianSub1620C=0.184T=0.816
The Genome Aggregation DatabaseEuropeSub18478C=0.226T=0.773
The Genome Aggregation DatabaseGlobalStudy-wide29918C=0.361T=0.639
The Genome Aggregation DatabaseOtherSub302C=0.260T=0.740
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.439T=0.560
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.232T=0.768
PMID Title Author Journal
20584212Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.Saccone NLGenes Brain Behav
21850187Pediatric cataract, myopic astigmatism, familial exudative vitreoretinopathy and primary open-angle glaucoma co-segregating in a family.Mackey DAMol Vis
27827986Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence.Zuo LGenes (Basel)
19760673Association of CHRN genes with "dizziness" to tobacco.Ehringer MAAm J Med Genet B Neuropsychiatr Genet
27327258Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research.Wen LTransl Psychiatry
21191315Genetic association of bipolar disorder with the beta(3) nicotinic receptor subunit gene.Hartz SMPsychiatr Genet
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs19551850.000184nicotine dependence17158188

eQTL of rs1955185 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1955185 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr84255878642559348E0679139
chr84255950742559557E0679860
chr84255956442559738E0679917
chr84255978342560036E06710136
chr84257551642576584E06925869
chr84255878642559348E0719139
chr84255950742559557E0719860
chr84255956442559738E0719917
chr84257551642576584E07125869
chr84259581842596743E07146171
chr84259678542596841E07147138
chr84254736742548251E072-1396
chr84257551642576584E07225869
chr84259581842596743E07246171
chr84257551642576584E07325869
chr84255878642559348E0749139
chr84255950742559557E0749860
chr84255956442559738E0749917
chr84255978342560036E07410136
chr84256031142560370E07410664
chr84257551642576584E07425869
chr84259678542596841E07447138
chr84259699542597311E07447348
chr84251152842512118E081-37529
chr84256031142560370E08110664
chr84256054542560595E08110898
chr84256060442560725E08110957
chr84259699542597311E08147348