rs1982389

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

GPR141 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0031 (947/29974,GnomAD)
G=0028 (826/29116,TOPMED)
G=0017 (87/5008,1000G)
G=0053 (205/3854,ALSPAC)
G=0057 (210/3708,TWINSUK)

Position: chr7:37687349 (GRCh38.p7) (7p14.1)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 16 Enhancers around

Promoter: 0 Promoter around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 7	NC_000007.14:g.37687349A>G
GRCh37.p13 chr 7	NC_000007.13:g.37726951A>G

Gene: GPR141, G protein-coupled receptor 141(plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
GPR141 transcript	NM_181791.1:c.	N/A	Genic Upstream Transcript Variant
GPR141 transcript variant X1	XM_011515374.2:c.	N/A	Intron Variant
GPR141 transcript variant X2	XM_011515375.2:c.	N/A	Intron Variant
GPR141 transcript variant X11	XM_011515389.2:c.	N/A	Intron Variant
GPR141 transcript variant X3	XM_017012160.1:c.	N/A	Intron Variant
GPR141 transcript variant X4	XM_017012161.1:c.	N/A	Intron Variant
GPR141 transcript variant X5	XM_017012162.1:c.	N/A	Intron Variant
GPR141 transcript variant X6	XM_017012163.1:c.	N/A	Intron Variant
GPR141 transcript variant X5	XM_017012164.1:c.	N/A	Intron Variant
GPR141 transcript variant X9	XM_017012166.1:c.	N/A	Intron Variant
GPR141 transcript variant X13	XM_017012167.1:c.	N/A	Intron Variant
GPR141 transcript variant X8	XM_011515383.2:c.	N/A	Genic Upstream Transcript Variant
GPR141 transcript variant X8	XM_011515385.2:c.	N/A	Genic Upstream Transcript Variant
GPR141 transcript variant X10	XM_011515386.2:c.	N/A	Genic Upstream Transcript Variant
GPR141 transcript variant X12	XM_011515388.2:c.	N/A	Genic Upstream Transcript Variant
GPR141 transcript variant X7	XM_017012165.1:c.	N/A	Genic Upstream Transcript Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.998	G=0.002
1000Genomes	American	Sub	694	A=0.970	G=0.030
1000Genomes	East Asian	Sub	1008	A=1.000	G=0.000
1000Genomes	Europe	Sub	1006	A=0.951	G=0.049
1000Genomes	Global	Study-wide	5008	A=0.983	G=0.017
1000Genomes	South Asian	Sub	978	A=0.990	G=0.010
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.947	G=0.053
The Genome Aggregation Database	African	Sub	8708	A=0.987	G=0.013
The Genome Aggregation Database	American	Sub	838	A=0.970	G=0.030
The Genome Aggregation Database	East Asian	Sub	1620	A=1.000	G=0.000
The Genome Aggregation Database	Europe	Sub	18506	A=0.957	G=0.042
The Genome Aggregation Database	Global	Study-wide	29974	A=0.968	G=0.031
The Genome Aggregation Database	Other	Sub	302	A=0.930	G=0.070
Trans-Omics for Precision Medicine	Global	Study-wide	29116	A=0.971	G=0.028
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.943	G=0.057

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

P-Value

SNP ID	p-value	Traits	Study
rs1982389	0.00023	alcohol dependence	20201924

eQTL of rs1982389 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs1982389 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr7	37683464	37684003	E067	-42948
chr7	37683464	37684003	E068	-42948
chr7	37683464	37684003	E069	-42948
chr7	37683464	37684003	E070	-42948
chr7	37748229	37748296	E070	21278
chr7	37683464	37684003	E071	-42948
chr7	37768211	37769081	E071	41260
chr7	37683464	37684003	E074	-42948
chr7	37747317	37747652	E081	20366
chr7	37747685	37748120	E081	20734
chr7	37748229	37748296	E081	21278
chr7	37746918	37747012	E082	19967
chr7	37747106	37747263	E082	20155
chr7	37747317	37747652	E082	20366
chr7	37747685	37748120	E082	20734
chr7	37748229	37748296	E082	21278