rs1999627

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0089 (2683/29930,GnomAD)
A=0069 (2022/29118,TOPMED)
A=0132 (660/5008,1000G)
A=0114 (441/3854,ALSPAC)
A=0121 (449/3708,TWINSUK)
chr10:119457411 (GRCh38.p7) (10q26.11)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.119457411G>A
GRCh37.p13 chr 10NC_000010.10:g.121216923G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.995A=0.005
1000GenomesAmericanSub694G=0.890A=0.110
1000GenomesEast AsianSub1008G=0.700A=0.300
1000GenomesEuropeSub1006G=0.911A=0.089
1000GenomesGlobalStudy-wide5008G=0.868A=0.132
1000GenomesSouth AsianSub978G=0.810A=0.190
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.886A=0.114
The Genome Aggregation DatabaseAfricanSub8714G=0.971A=0.029
The Genome Aggregation DatabaseAmericanSub838G=0.900A=0.100
The Genome Aggregation DatabaseEast AsianSub1612G=0.717A=0.283
The Genome Aggregation DatabaseEuropeSub18464G=0.899A=0.101
The Genome Aggregation DatabaseGlobalStudy-wide29930G=0.910A=0.089
The Genome Aggregation DatabaseOtherSub302G=0.910A=0.090
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.930A=0.069
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.879A=0.121
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs19996270.00019alcohol dependence20201924

eQTL of rs1999627 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1999627 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr10121253817121254967E06736894
chr10121254976121255070E06738053
chr10121254976121255070E06838053
chr10121253817121254967E06936894
chr10121181127121182266E070-34657
chr10121182308121182358E070-34565
chr10121182435121182619E070-34304
chr10121253495121253632E07036572
chr10121253817121254967E07036894
chr10121254976121255070E07038053
chr10121255100121255301E07038177
chr10121181127121182266E071-34657
chr10121253817121254967E07136894
chr10121184179121184232E072-32691
chr10121184286121184497E072-32426
chr10121184502121184576E072-32347
chr10121184598121184658E072-32265
chr10121253495121253632E07236572
chr10121253817121254967E07236894
chr10121171630121174291E073-42632
chr10121248829121249663E07431906
chr10121171630121174291E081-42632
chr10121249761121250077E08132838
chr10121251459121252290E08134536
chr10121263230121263284E08246307