rs2026075

Homo sapiens
G>A
KANK1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0295 (8802/29796,GnomAD)
G==0338 (1692/5008,1000G)
G==0286 (1102/3854,ALSPAC)
G==0273 (1011/3708,TWINSUK)
chr9:520886 (GRCh38.p7) (9p24.3)
ND
GWASdb2
1   publication(s)
See rs on genome
360 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.520886G>A
GRCh37.p13 chr 9NC_000009.11:g.520886G>A
KANK1 RefSeqGeneNG_016331.2:g.55593G>A

Gene: KANK1, KN motif and ankyrin repeat domains 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
KANK1 transcript variant 3NM_001256876.1:c.N/AIntron Variant
KANK1 transcript variant 4NM_001256877.1:c.N/AIntron Variant
KANK1 transcript variant 1NM_015158.3:c.N/AIntron Variant
KANK1 transcript variant 2NM_153186.4:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X2XM_005251411.2:c.N/AIntron Variant
KANK1 transcript variant X5XM_011517819.1:c.N/AIntron Variant
KANK1 transcript variant X4XM_017014513.1:c.N/AIntron Variant
KANK1 transcript variant X10XM_017014515.1:c.N/AIntron Variant
KANK1 transcript variant X13XM_017014518.1:c.N/AIntron Variant
KANK1 transcript variant X15XM_017014520.1:c.N/AIntron Variant
KANK1 transcript variant X18XM_017014523.1:c.N/AIntron Variant
KANK1 transcript variant X29XM_017014528.1:c.N/AIntron Variant
KANK1 transcript variant X24XM_005251414.3:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X22XM_005251415.2:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X26XM_005251416.2:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X23XM_005251417.3:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X25XM_005251418.2:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X27XM_005251419.2:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X8XM_006716743.2:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X6XM_011517820.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X7XM_011517821.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X1XM_017014511.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X3XM_017014512.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X9XM_017014514.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X11XM_017014516.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X12XM_017014517.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X14XM_017014519.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X16XM_017014521.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X17XM_017014522.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X19XM_017014524.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X20XM_017014525.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X21XM_017014526.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X28XM_017014527.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X30XM_017014529.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X31XM_017014530.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X32XM_017014531.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X33XM_017014532.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X34XM_017014533.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X35XM_017014534.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X36XM_017014535.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X37XM_017014536.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X38XM_017014537.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X39XM_017014538.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X41XM_017014539.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X42XM_017014540.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X43XM_017014541.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X44XM_017014542.1:c.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X40XR_001746257.1:n.N/AGenic Upstream Transcript Variant
KANK1 transcript variant X45XR_001746258.1:n.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.335A=0.665
1000GenomesAmericanSub694G=0.440A=0.560
1000GenomesEast AsianSub1008G=0.394A=0.606
1000GenomesEuropeSub1006G=0.288A=0.712
1000GenomesGlobalStudy-wide5008G=0.338A=0.662
1000GenomesSouth AsianSub978G=0.260A=0.740
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.286A=0.714
The Genome Aggregation DatabaseAfricanSub8580G=0.308A=0.692
The Genome Aggregation DatabaseAmericanSub838G=0.460A=0.540
The Genome Aggregation DatabaseEast AsianSub1608G=0.393A=0.607
The Genome Aggregation DatabaseEuropeSub18468G=0.274A=0.725
The Genome Aggregation DatabaseGlobalStudy-wide29796G=0.295A=0.704
The Genome Aggregation DatabaseOtherSub302G=0.230A=0.770
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.273A=0.727
PMID Title Author Journal
22377092ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.Wang KSDrug Alcohol Depend

P-Value

SNP ID p-value Traits Study
rs20260751.48E-06nicotine dependence (smoking)22377092

eQTL of rs2026075 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2026075 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr9513289513339E067-7547
chr9531455531647E06710569
chr9531769531905E06710883
chr9531935532183E06711049
chr9532466532799E06711580
chr9532810533139E06711924
chr9533317533523E06712431
chr9533684533874E06712798
chr9533985534531E06713099
chr9534669534943E06713783
chr9534972535361E06714086
chr9535463535734E06714577
chr9535743535849E06714857
chr9537040537411E06716154
chr9537498537586E06716612
chr9537646537700E06716760
chr9537748537933E06716862
chr9538059538151E06717173
chr9538240538389E06717354
chr9544406544559E06723520
chr9544637544773E06723751
chr9544890545079E06724004
chr9545245545352E06724359
chr9545536545720E06724650
chr9545724545829E06724838
chr9546262547628E06725376
chr9547741547856E06726855
chr9547891548104E06727005
chr9548193548243E06727307
chr9549261549344E06728375
chr9558445558593E06737559
chr9560046560243E06739160
chr9560348560446E06739462
chr9560500560550E06739614
chr9560701560789E06739815
chr9560845561205E06739959
chr9561468561924E06740582
chr9562439562642E06741553
chr9562912563844E06742026
chr9563874564064E06742988
chr9569032570658E06748146
chr9570713570786E06749827
chr9471212471329E068-49557
chr9471382471521E068-49365
chr9506162506581E068-14305
chr9512982513130E068-7756
chr9513289513339E068-7547
chr9516802516929E068-3957
chr9517302517532E068-3354
chr9517540517606E068-3280
chr9518043518514E068-2372
chr9518590518863E068-2023
chr9519208519255E068-1631
chr9522347522756E0681461
chr9522777522925E0681891
chr9523233523540E0682347
chr9523606523708E0682720
chr9524123524262E0683237
chr9524274524366E0683388
chr9524426524494E0683540
chr9524679524729E0683793
chr9531088531237E06810202
chr9531312531362E06810426
chr9531455531647E06810569
chr9531769531905E06810883
chr9531935532183E06811049
chr9532466532799E06811580
chr9532810533139E06811924
chr9533317533523E06812431
chr9533684533874E06812798
chr9533985534531E06813099
chr9534669534943E06813783
chr9534972535361E06814086
chr9535463535734E06814577
chr9535743535849E06814857
chr9536038536078E06815152
chr9536407536466E06815521
chr9536679536748E06815793
chr9536786536914E06815900
chr9536921537020E06816035
chr9537040537411E06816154
chr9537498537586E06816612
chr9537646537700E06816760
chr9537748537933E06816862
chr9544239544289E06823353
chr9544406544559E06823520
chr9544637544773E06823751
chr9544890545079E06824004
chr9545245545352E06824359
chr9545536545720E06824650
chr9545724545829E06824838
chr9547891548104E06827005
chr9548193548243E06827307
chr9548384548463E06827498
chr9552035552935E06831149
chr9560845561205E06839959
chr9561468561924E06840582
chr9562439562642E06841553
chr9564319564395E06843433
chr9564787564837E06843901
chr9570713570786E06849827
chr9471212471329E069-49557
chr9471382471521E069-49365
chr9512982513130E069-7756
chr9513289513339E069-7547
chr9522777522925E0691891
chr9523233523540E0692347
chr9530500530657E0699614
chr9530714530987E0699828
chr9531088531237E06910202
chr9531312531362E06910426
chr9531455531647E06910569
chr9531769531905E06910883
chr9531935532183E06911049
chr9532466532799E06911580
chr9532810533139E06911924
chr9533317533523E06912431
chr9533684533874E06912798
chr9533985534531E06913099
chr9534669534943E06913783
chr9534972535361E06914086
chr9535743535849E06914857
chr9536921537020E06916035
chr9537040537411E06916154
chr9537498537586E06916612
chr9537646537700E06916760
chr9537748537933E06916862
chr9538059538151E06917173
chr9538240538389E06917354
chr9544239544289E06923353
chr9544406544559E06923520
chr9544637544773E06923751
chr9544890545079E06924004
chr9545245545352E06924359
chr9545536545720E06924650
chr9545724545829E06924838
chr9546262547628E06925376
chr9547741547856E06926855
chr9547891548104E06927005
chr9548193548243E06927307
chr9549261549344E06928375
chr9549370550149E06928484
chr9552035552935E06931149
chr9560348560446E06939462
chr9560500560550E06939614
chr9560701560789E06939815
chr9560845561205E06939959
chr9561468561924E06940582
chr9562439562642E06941553
chr9562912563844E06942026
chr9563874564064E06942988
chr9564319564395E06943433
chr9564787564837E06943901
chr9564856564906E06943970
chr9564910564998E06944024
chr9567283567458E06946397
chr9567464567885E06946578
chr9569032570658E06948146
chr9570713570786E06949827
chr9471212471329E070-49557
chr9471382471521E070-49365
chr9471641471695E070-49191
chr9471788471868E070-49018
chr9534972535361E07014086
chr9471212471329E071-49557
chr9471382471521E071-49365
chr9506162506581E071-14305
chr9506711506889E071-13997
chr9512033512153E071-8733
chr9512320512364E071-8522
chr9512982513130E071-7756
chr9513289513339E071-7547
chr9516612516696E071-4190
chr9516802516929E071-3957
chr9517302517532E071-3354
chr9517540517606E071-3280
chr9520769520824E071-62
chr9520915520965E07129
chr9522347522756E0711461
chr9522777522925E0711891
chr9523233523540E0712347
chr9523606523708E0712720
chr9524679524729E0713793
chr9530500530657E0719614
chr9530714530987E0719828
chr9531088531237E07110202
chr9531312531362E07110426
chr9531455531647E07110569
chr9531769531905E07110883
chr9531935532183E07111049
chr9532466532799E07111580
chr9532810533139E07111924
chr9533317533523E07112431
chr9533684533874E07112798
chr9533985534531E07113099
chr9535463535734E07114577
chr9535743535849E07114857
chr9536038536078E07115152
chr9536679536748E07115793
chr9536786536914E07115900
chr9536921537020E07116035
chr9537040537411E07116154
chr9537498537586E07116612
chr9537646537700E07116760
chr9537748537933E07116862
chr9538059538151E07117173
chr9538240538389E07117354
chr9544239544289E07123353
chr9544406544559E07123520
chr9544637544773E07123751
chr9544890545079E07124004
chr9545245545352E07124359
chr9545536545720E07124650
chr9545724545829E07124838
chr9549261549344E07128375
chr9549370550149E07128484
chr9551166551357E07130280
chr9551636551714E07130750
chr9552035552935E07131149
chr9553489553539E07132603
chr9557794558197E07136908
chr9558445558593E07137559
chr9559734560039E07138848
chr9560046560243E07139160
chr9560348560446E07139462
chr9560500560550E07139614
chr9560701560789E07139815
chr9560845561205E07139959
chr9561468561924E07140582
chr9562439562642E07141553
chr9564787564837E07143901
chr9564856564906E07143970
chr9564910564998E07144024
chr9567283567458E07146397
chr9567464567885E07146578
chr9570713570786E07149827
chr9471212471329E072-49557
chr9471382471521E072-49365
chr9503187503271E072-17615
chr9512033512153E072-8733
chr9512320512364E072-8522
chr9512982513130E072-7756
chr9513289513339E072-7547
chr9517302517532E072-3354
chr9520769520824E072-62
chr9520915520965E07229
chr9521278521519E072392
chr9522777522925E0721891
chr9523233523540E0722347
chr9523606523708E0722720
chr9524123524262E0723237
chr9524274524366E0723388
chr9524426524494E0723540
chr9530714530987E0729828
chr9531088531237E07210202
chr9531312531362E07210426
chr9531455531647E07210569
chr9531769531905E07210883
chr9531935532183E07211049
chr9532466532799E07211580
chr9532810533139E07211924
chr9533317533523E07212431
chr9533684533874E07212798
chr9533985534531E07213099
chr9534669534943E07213783
chr9534972535361E07214086
chr9535463535734E07214577
chr9535743535849E07214857
chr9537646537700E07216760
chr9537748537933E07216862
chr9538059538151E07217173
chr9544890545079E07224004
chr9545245545352E07224359
chr9545536545720E07224650
chr9545724545829E07224838
chr9547891548104E07227005
chr9549261549344E07228375
chr9549370550149E07228484
chr9552035552935E07231149
chr9560845561205E07239959
chr9561468561924E07240582
chr9562439562642E07241553
chr9562912563844E07242026
chr9563874564064E07242988
chr9564319564395E07243433
chr9564787564837E07243901
chr9564856564906E07243970
chr9564910564998E07244024
chr9569032570658E07248146
chr9570713570786E07249827
chr9506162506581E073-14305
chr9522347522756E0731461
chr9522777522925E0731891
chr9532810533139E07311924
chr9533317533523E07312431
chr9533684533874E07312798
chr9534669534943E07313783
chr9534972535361E07314086
chr9535463535734E07314577
chr9535743535849E07314857
chr9536921537020E07316035
chr9537040537411E07316154
chr9544890545079E07324004
chr9545245545352E07324359
chr9545536545720E07324650
chr9545724545829E07324838
chr9546262547628E07325376
chr9471212471329E074-49557
chr9471382471521E074-49365
chr9510944511049E074-9837
chr9511129511189E074-9697
chr9511249511305E074-9581
chr9512033512153E074-8733
chr9512320512364E074-8522
chr9512982513130E074-7756
chr9513289513339E074-7547
chr9521278521519E074392
chr9522347522756E0741461
chr9522777522925E0741891
chr9531088531237E07410202
chr9531312531362E07410426
chr9531455531647E07410569
chr9531769531905E07410883
chr9531935532183E07411049
chr9532466532799E07411580
chr9532810533139E07411924
chr9533317533523E07412431
chr9533684533874E07412798
chr9533985534531E07413099
chr9534669534943E07413783
chr9534972535361E07414086
chr9535463535734E07414577
chr9535743535849E07414857
chr9536407536466E07415521
chr9536679536748E07415793
chr9536786536914E07415900
chr9536921537020E07416035
chr9537040537411E07416154
chr9537498537586E07416612
chr9538240538389E07417354
chr9544239544289E07423353
chr9544406544559E07423520
chr9544637544773E07423751
chr9544890545079E07424004
chr9545245545352E07424359
chr9545536545720E07424650
chr9545724545829E07424838
chr9546262547628E07425376
chr9547741547856E07426855
chr9547891548104E07427005
chr9548193548243E07427307
chr9552035552935E07431149
chr9562439562642E07441553
chr9569032570658E07448146
chr9570713570786E07449827
chr9529404529454E0818518
chr9529589529642E0818703
chr9546262547628E08125376
chr9547741547856E08126855
chr9552035552935E08131149









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr9503273506125E067-14761
chr9503273506125E068-14761
chr9503273506125E069-14761
chr9503273506125E070-14761
chr9503273506125E071-14761
chr9503273506125E072-14761
chr9503273506125E073-14761
chr9503273506125E074-14761
chr9503273506125E082-14761