SNP Detail Info-rs2045935

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0195 (5802/29632,GnomAD)
G=0166 (4849/29118,TOPMED)
G=0289 (1446/5008,1000G)
G=0221 (851/3854,ALSPAC)
G=0225 (833/3708,TWINSUK)

Position: chr11:27316296 (GRCh38.p7) (11p14.1)

Phenotype: OD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 9 Enhancers around

Promoter: 10 Promoters around

Sequence Name	Change(s)
GRCh38.p7 chr 11	NC_000011.10:g.27316296A>G
GRCh37.p13 chr 11	NC_000011.9:g.27337843A>G

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.933	G=0.067
1000Genomes	American	Sub	694	A=0.590	G=0.410
1000Genomes	East Asian	Sub	1008	A=0.569	G=0.431
1000Genomes	Europe	Sub	1006	A=0.788	G=0.212
1000Genomes	Global	Study-wide	5008	A=0.711	G=0.289
1000Genomes	South Asian	Sub	978	A=0.560	G=0.440
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.779	G=0.221
The Genome Aggregation Database	African	Sub	8678	A=0.908	G=0.092
The Genome Aggregation Database	American	Sub	836	A=0.560	G=0.440
The Genome Aggregation Database	East Asian	Sub	1612	A=0.553	G=0.447
The Genome Aggregation Database	Europe	Sub	18204	A=0.788	G=0.212
The Genome Aggregation Database	Global	Study-wide	29632	A=0.804	G=0.195
The Genome Aggregation Database	Other	Sub	302	A=0.810	G=0.190
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.833	G=0.166
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.775	G=0.225

PMID	Title	Author	Journal
23183491	Genome-wide association study identifies a potent locus associated with human opioid sensitivity.	Nishizawa D	Mol Psychiatry

SNP ID	p-value	Traits	Study
rs2045935	5.37E-05	Opioid sensitivity	23183491

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr11	27382898	27383006	E067	45055
chr11	27383120	27383187	E067	45277
chr11	27382898	27383006	E069	45055
chr11	27383120	27383187	E069	45277
chr11	27383205	27383758	E071	45362
chr11	27315082	27315988	E081	-21855
chr11	27330604	27331164	E081	-6679
chr11	27372800	27372887	E081	34957
chr11	27383120	27383187	E081	45277

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr11	27384039	27385566	E067	46196
chr11	27384039	27385566	E068	46196
chr11	27384039	27385566	E069	46196
chr11	27384039	27385566	E070	46196
chr11	27384039	27385566	E071	46196
chr11	27384039	27385566	E072	46196
chr11	27384039	27385566	E073	46196
chr11	27384039	27385566	E074	46196
chr11	27384039	27385566	E081	46196
chr11	27384039	27385566	E082	46196

rs2045935