rs2045966

Homo sapiens
C>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0037 (1131/29938,GnomAD)
G=0027 (790/29118,TOPMED)
G=0043 (217/5008,1000G)
G=0049 (189/3854,ALSPAC)
G=0048 (179/3708,TWINSUK)
chr8:97581926 (GRCh38.p7) (8q22.1)
ND
GWASCatalog
1   publication(s)
See rs on genome
31 Enhancers around
14 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.97581926C>G
GRCh37.p13 chr 8NC_000008.10:g.98594154C>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.999G=0.001
1000GenomesAmericanSub694C=0.970G=0.030
1000GenomesEast AsianSub1008C=0.909G=0.091
1000GenomesEuropeSub1006C=0.945G=0.055
1000GenomesGlobalStudy-wide5008C=0.957G=0.043
1000GenomesSouth AsianSub978C=0.950G=0.050
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.951G=0.049
The Genome Aggregation DatabaseAfricanSub8704C=0.991G=0.009
The Genome Aggregation DatabaseAmericanSub838C=0.980G=0.020
The Genome Aggregation DatabaseEast AsianSub1618C=0.928G=0.072
The Genome Aggregation DatabaseEuropeSub18476C=0.950G=0.049
The Genome Aggregation DatabaseGlobalStudy-wide29938C=0.962G=0.037
The Genome Aggregation DatabaseOtherSub302C=0.970G=0.030
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.972G=0.027
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.952G=0.048
PMID Title Author Journal
27488534Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.Patel YMCancer Res

P-Value

SNP ID p-value Traits Study
rs20459663E-08nicotine metabolite ratio in current smokers27488534

eQTL of rs2045966 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2045966 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr89860800098608680E06713846
chr89861926998619977E06725115
chr89856550698566402E068-27752
chr89857202898572244E068-21910
chr89861926998619977E06825115
chr89863502798635544E06840873
chr89856550698566402E069-27752
chr89861926998619977E06925115
chr89857202898572244E070-21910
chr89857286398573116E070-21038
chr89858165798582206E070-11948
chr89861885898619045E07024704
chr89861917398619255E07025019
chr89861926998619977E07025115
chr89856340898563461E071-30693
chr89856550698566402E071-27752
chr89861917398619255E07125019
chr89861926998619977E07125115
chr89856550698566402E072-27752
chr89861885898619045E07224704
chr89861917398619255E07225019
chr89861926998619977E07225115
chr89859464998595044E073495
chr89857202898572244E074-21910
chr89860800098608680E07413846
chr89860872898608812E07414574
chr89861917398619255E07425019
chr89861926998619977E07425115
chr89861885898619045E08124704
chr89861917398619255E08125019
chr89861885898619045E08224704










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr89857225898572693E068-21461
chr89861040098610951E06816246
chr89857225898572693E069-21461
chr89861040098610951E06916246
chr89861040098610951E07016246
chr89857225898572693E071-21461
chr89861040098610951E07116246
chr89857225898572693E072-21461
chr89861040098610951E07216246
chr89857225898572693E073-21461
chr89861040098610951E07316246
chr89857225898572693E074-21461
chr89857225898572693E081-21461
chr89861040098610951E08216246