rs2137457

Homo sapiens
G>A
LOC105377110 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0177 (5318/29952,GnomAD)
G==0136 (3971/29118,TOPMED)
G==0247 (1238/5008,1000G)
G==0200 (770/3854,ALSPAC)
G==0202 (749/3708,TWINSUK)
chr3:59120187 (GRCh38.p7) (3p14.2)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
13 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.59120187G>A
GRCh37.p13 chr 3NC_000003.11:g.59105913G>A

Gene: LOC105377110, uncharacterized LOC105377110(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105377110 transcript variant X1XR_001740430.1:n.N/AIntron Variant
LOC105377110 transcript variant X1XR_001740431.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.009A=0.991
1000GenomesAmericanSub694G=0.170A=0.830
1000GenomesEast AsianSub1008G=0.539A=0.461
1000GenomesEuropeSub1006G=0.195A=0.805
1000GenomesGlobalStudy-wide5008G=0.247A=0.753
1000GenomesSouth AsianSub978G=0.370A=0.630
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.200A=0.800
The Genome Aggregation DatabaseAfricanSub8730G=0.038A=0.962
The Genome Aggregation DatabaseAmericanSub834G=0.220A=0.780
The Genome Aggregation DatabaseEast AsianSub1616G=0.571A=0.429
The Genome Aggregation DatabaseEuropeSub18470G=0.207A=0.792
The Genome Aggregation DatabaseGlobalStudy-wide29952G=0.177A=0.822
The Genome Aggregation DatabaseOtherSub302G=0.180A=0.820
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.136A=0.863
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.202A=0.798
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs21374570.000648alcohol dependence21314694

eQTL of rs2137457 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2137457 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr35910173459101784E067-4129
chr35910204459102094E067-3819
chr35911059059110923E0674677
chr35911059059110923E0684677
chr35911103159111090E0685118
chr35912820359128633E06822290
chr35911059059110923E0694677
chr35912820359128633E06922290
chr35912820359128633E07122290
chr35911059059110923E0724677
chr35912820359128633E07222290
chr35911059059110923E0734677
chr35912820359128633E07422290