rs2166753

Homo sapiens
G>A / G>C
None
Check p-value
SNV (Single Nucleotide Variation)
G==0453 (13560/29878,GnomAD)
G==0443 (12898/29118,TOPMED)
G==0468 (2342/5008,1000G)
G==0451 (1739/3854,ALSPAC)
G==0461 (1709/3708,TWINSUK)
chr3:118362178 (GRCh38.p7) (3q13.32)
AD
GWASdb2
1   publication(s)
See rs on genome
95 Enhancers around
50 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.118362178G>A
GRCh38.p7 chr 3NC_000003.12:g.118362178G>C
GRCh37.p13 chr 3NC_000003.11:g.118081025G>A
GRCh37.p13 chr 3NC_000003.11:g.118081025G>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.460A=0.540
1000GenomesAmericanSub694G=0.500A=0.500
1000GenomesEast AsianSub1008G=0.525A=0.475
1000GenomesEuropeSub1006G=0.451A=0.549
1000GenomesGlobalStudy-wide5008G=0.468A=0.532
1000GenomesSouth AsianSub978G=0.420A=0.580
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.451A=0.549
The Genome Aggregation DatabaseAfricanSub8680G=0.451A=0.549
The Genome Aggregation DatabaseAmericanSub834G=0.520A=0.480
The Genome Aggregation DatabaseEast AsianSub1610G=0.488A=0.512
The Genome Aggregation DatabaseEuropeSub18452G=0.451A=0.548
The Genome Aggregation DatabaseGlobalStudy-wide29878G=0.453A=0.546
The Genome Aggregation DatabaseOtherSub302G=0.320A=0.680
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.443A=0.557
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.461A=0.539
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs21667530.00093alcohol dependence20201924

eQTL of rs2166753 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2166753 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3116113379116113482E067-47469
chr3116118640116118842E067-42109
chr3116118886116118942E067-42009
chr3116143007116143100E067-17851
chr3116143574116143659E067-17292
chr3116143961116144013E067-16938
chr3116144046116144201E067-16750
chr3116158926116159431E067-1520
chr3116164769116165559E0673818
chr3116192557116192721E06731606
chr3116193030116193116E06732079
chr3116193195116193363E06732244
chr3116193446116193660E06732495
chr3116116107116116157E068-44794
chr3116118640116118842E068-42109
chr3116118886116118942E068-42009
chr3116124047116124122E068-36829
chr3116124211116124341E068-36610
chr3116132313116132413E068-28538
chr3116143007116143100E068-17851
chr3116143574116143659E068-17292
chr3116143961116144013E068-16938
chr3116160593116160751E068-200
chr3116168425116168745E0687474
chr3116171763116171930E06810812
chr3116132313116132413E069-28538
chr3116143574116143659E069-17292
chr3116143961116144013E069-16938
chr3116144046116144201E069-16750
chr3116160593116160751E069-200
chr3116168425116168745E0697474
chr3116124047116124122E070-36829
chr3116124211116124341E070-36610
chr3116142136116142703E070-18248
chr3116142912116142974E070-17977
chr3116143007116143100E070-17851
chr3116143574116143659E070-17292
chr3116118640116118842E071-42109
chr3116118886116118942E071-42009
chr3116143574116143659E071-17292
chr3116143961116144013E071-16938
chr3116144046116144201E071-16750
chr3116158926116159431E071-1520
chr3116168425116168745E0717474
chr3116168884116168943E0717933
chr3116169010116169146E0718059
chr3116113379116113482E072-47469
chr3116118640116118842E072-42109
chr3116124047116124122E072-36829
chr3116124211116124341E072-36610
chr3116143574116143659E072-17292
chr3116143961116144013E072-16938
chr3116144046116144201E072-16750
chr3116193030116193116E07232079
chr3116193195116193363E07232244
chr3116193446116193660E07232495
chr3116113379116113482E073-47469
chr3116128785116128835E073-32116
chr3116142136116142703E073-18248
chr3116142912116142974E073-17977
chr3116143007116143100E073-17851
chr3116143574116143659E073-17292
chr3116143961116144013E073-16938
chr3116193195116193363E07332244
chr3116193446116193660E07332495
chr3116193751116194022E07332800
chr3116113379116113482E074-47469
chr3116118640116118842E074-42109
chr3116118886116118942E074-42009
chr3116124047116124122E074-36829
chr3116124211116124341E074-36610
chr3116128785116128835E074-32116
chr3116132313116132413E074-28538
chr3116143007116143100E074-17851
chr3116143574116143659E074-17292
chr3116143961116144013E074-16938
chr3116144046116144201E074-16750
chr3116144232116144330E074-16621
chr3116158926116159431E074-1520
chr3116160593116160751E074-200
chr3116168425116168745E0747474
chr3116168884116168943E0747933
chr3116169010116169146E0748059
chr3116193030116193116E07432079
chr3116142136116142703E081-18248
chr3116168425116168745E0817474
chr3116168884116168943E0817933
chr3116169010116169146E0818059
chr3116189567116189765E08128616
chr3116189832116189993E08128881
chr3116193446116193660E08132495
chr3116193751116194022E08132800
chr3116193030116193116E08232079
chr3116193195116193363E08232244
chr3116193446116193660E08232495










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr3116161411116161742E067460
chr3116162026116162494E0671075
chr3116162863116163025E0671912
chr3116163075116163647E0672124
chr3116163679116164697E0672728
chr3116161411116161742E068460
chr3116162026116162494E0681075
chr3116162863116163025E0681912
chr3116163075116163647E0682124
chr3116163679116164697E0682728
chr3116161411116161742E069460
chr3116162026116162494E0691075
chr3116162863116163025E0691912
chr3116163075116163647E0692124
chr3116163679116164697E0692728
chr3116161411116161742E070460
chr3116162026116162494E0701075
chr3116162863116163025E0701912
chr3116163075116163647E0702124
chr3116163679116164697E0702728
chr3116161411116161742E071460
chr3116162026116162494E0711075
chr3116162863116163025E0711912
chr3116163075116163647E0712124
chr3116163679116164697E0712728
chr3116161411116161742E072460
chr3116162026116162494E0721075
chr3116162863116163025E0721912
chr3116163075116163647E0722124
chr3116163679116164697E0722728
chr3116161411116161742E073460
chr3116162026116162494E0731075
chr3116162863116163025E0731912
chr3116163075116163647E0732124
chr3116163679116164697E0732728
chr3116161411116161742E074460
chr3116162026116162494E0741075
chr3116162863116163025E0741912
chr3116163075116163647E0742124
chr3116163679116164697E0742728
chr3116161411116161742E081460
chr3116162026116162494E0811075
chr3116162863116163025E0811912
chr3116163075116163647E0812124
chr3116163679116164697E0812728
chr3116161411116161742E082460
chr3116162026116162494E0821075
chr3116162863116163025E0821912
chr3116163075116163647E0822124
chr3116163679116164697E0822728