rs2168778

Homo sapiens
T>C
ZNF225 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0206 (6172/29940,GnomAD)
T==0225 (6562/29118,TOPMED)
T==0314 (1572/5008,1000G)
T==0115 (443/3854,ALSPAC)
T==0119 (441/3708,TWINSUK)
chr19:44127066 (GRCh38.p7) (19q13.31)
AD
GWASdb2
1   publication(s)
See rs on genome
29 Enhancers around
60 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 19NC_000019.10:g.44127066T>C
GRCh37.p13 chr 19NC_000019.9:g.44631219T>C

Gene: ZNF225, zinc finger protein 225(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ZNF225 transcript variant 2NM_001321685.1:c.N/AIntron Variant
ZNF225 transcript variant 1NM_013362.3:c.N/AIntron Variant
ZNF225 transcript variant X1XM_011527285.2:c.N/AIntron Variant
ZNF225 transcript variant X2XM_011527286.2:c.N/AIntron Variant
ZNF225 transcript variant X3XM_005259223.3:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.325C=0.675
1000GenomesAmericanSub694T=0.420C=0.580
1000GenomesEast AsianSub1008T=0.496C=0.504
1000GenomesEuropeSub1006T=0.129C=0.871
1000GenomesGlobalStudy-wide5008T=0.314C=0.686
1000GenomesSouth AsianSub978T=0.230C=0.770
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.115C=0.885
The Genome Aggregation DatabaseAfricanSub8706T=0.285C=0.715
The Genome Aggregation DatabaseAmericanSub838T=0.440C=0.560
The Genome Aggregation DatabaseEast AsianSub1610T=0.455C=0.545
The Genome Aggregation DatabaseEuropeSub18484T=0.137C=0.862
The Genome Aggregation DatabaseGlobalStudy-wide29940T=0.206C=0.793
The Genome Aggregation DatabaseOtherSub302T=0.130C=0.870
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.225C=0.774
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.119C=0.881
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs21687780.000105alcohol consumption23743675

eQTL of rs2168778 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2168778 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr194467075844670818E06739539
chr194467093344671011E06739714
chr194467104944671115E06739830
chr194461888344619034E068-12185
chr194467075844670818E06839539
chr194467093344671011E06839714
chr194460014844600194E069-31025
chr194460014844600194E070-31025
chr194461888344619034E070-12185
chr194461903744619091E070-12128
chr194461912544619165E070-12054
chr194467075844670818E07039539
chr194467093344671011E07039714
chr194467104944671115E07039830
chr194467187644671938E07040657
chr194461888344619034E071-12185
chr194467075844670818E07139539
chr194467075844670818E07239539
chr194467093344671011E07239714
chr194467075844670818E07439539
chr194467093344671011E07439714
chr194467187644671938E07440657
chr194467075844670818E08139539
chr194467093344671011E08139714
chr194467104944671115E08139830
chr194467187644671938E08140657
chr194460081644600930E082-30289
chr194467093344671011E08239714
chr194467104944671115E08239830









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr194459804744599722E067-31497
chr194461592544616789E067-14430
chr194461680644618482E067-12737
chr194464488144646741E06713662
chr194466849844670041E06737279
chr194459781244597885E068-33334
chr194459793544597989E068-33230
chr194459804744599722E068-31497
chr194461578744615827E068-15392
chr194461592544616789E068-14430
chr194461680644618482E068-12737
chr194464474344644803E06813524
chr194464488144646741E06813662
chr194466849844670041E06837279
chr194459804744599722E069-31497
chr194461578744615827E069-15392
chr194461592544616789E069-14430
chr194461680644618482E069-12737
chr194464488144646741E06913662
chr194466849844670041E06937279
chr194459804744599722E070-31497
chr194461592544616789E070-14430
chr194461680644618482E070-12737
chr194464474344644803E07013524
chr194464488144646741E07013662
chr194466849844670041E07037279
chr194459804744599722E071-31497
chr194461578744615827E071-15392
chr194461592544616789E071-14430
chr194461680644618482E071-12737
chr194464474344644803E07113524
chr194464488144646741E07113662
chr194466849844670041E07137279
chr194459804744599722E072-31497
chr194461592544616789E072-14430
chr194461680644618482E072-12737
chr194464474344644803E07213524
chr194464488144646741E07213662
chr194466849844670041E07237279
chr194459804744599722E073-31497
chr194461592544616789E073-14430
chr194461680644618482E073-12737
chr194464488144646741E07313662
chr194466849844670041E07337279
chr194459804744599722E074-31497
chr194461592544616789E074-14430
chr194461680644618482E074-12737
chr194464488144646741E07413662
chr194466849844670041E07437279
chr194459804744599722E081-31497
chr194461592544616789E081-14430
chr194461680644618482E081-12737
chr194464488144646741E08113662
chr194466849844670041E08137279
chr194459804744599722E082-31497
chr194461592544616789E082-14430
chr194461680644618482E082-12737
chr194464474344644803E08213524
chr194464488144646741E08213662
chr194466849844670041E08237279