rs2189816

Homo sapiens
T>C
GRM3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0093 (2803/29912,GnomAD)
C=0082 (2391/29118,TOPMED)
C=0066 (329/5008,1000G)
C=0143 (552/3854,ALSPAC)
C=0155 (576/3708,TWINSUK)
chr7:86712130 (GRCh38.p7) (7q21.12)
ND
GWASdb2
1   publication(s)
See rs on genome
328 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.86712130T>C
GRCh37.p13 chr 7NC_000007.13:g.86341446T>C

Gene: GRM3, glutamate metabotropic receptor 3(plus strand)

Molecule type Change Amino acid[Codon] SO Term
GRM3 transcript variant 1NM_000840.2:c.N/AIntron Variant
GRM3 transcript variant X1XM_011516088.1:c.N/AIntron Variant
GRM3 transcript variant X2XM_017012073.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.989C=0.011
1000GenomesAmericanSub694T=0.910C=0.090
1000GenomesEast AsianSub1008T=1.000C=0.000
1000GenomesEuropeSub1006T=0.855C=0.145
1000GenomesGlobalStudy-wide5008T=0.934C=0.066
1000GenomesSouth AsianSub978T=0.890C=0.110
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.857C=0.143
The Genome Aggregation DatabaseAfricanSub8728T=0.972C=0.028
The Genome Aggregation DatabaseAmericanSub838T=0.910C=0.090
The Genome Aggregation DatabaseEast AsianSub1576T=0.999C=0.001
The Genome Aggregation DatabaseEuropeSub18468T=0.866C=0.133
The Genome Aggregation DatabaseGlobalStudy-wide29912T=0.906C=0.093
The Genome Aggregation DatabaseOtherSub302T=0.910C=0.090
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.917C=0.082
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.845C=0.155
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs21898160.000000548Nicotine dependence (smoking)20158304
rs21898160.0000129alcohol and nictotine co-dependence20158304

eQTL of rs2189816 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2189816 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr78629256986292619E067-48827
chr78629268486292734E067-48712
chr78629643986296613E067-44833
chr78629709486297456E067-43990
chr78629750286297572E067-43874
chr78629774086297918E067-43528
chr78629843686298508E067-42938
chr78632746386327709E067-13737
chr78632806186328226E067-13220
chr78632910686329197E067-12249
chr78633477686334850E067-6596
chr78633525886335355E067-6091
chr78633565786335751E067-5695
chr78633577586335841E067-5605
chr78633593286335997E067-5449
chr78633620886336487E067-4959
chr78633661886336759E067-4687
chr78633682486337035E067-4411
chr78633709586337172E067-4274
chr78633724986337315E067-4131
chr78633735186338175E067-3271
chr78633842886338485E067-2961
chr78633860286338668E067-2778
chr78633982186339871E067-1575
chr78634005386340113E067-1333
chr78634018786340237E067-1209
chr78634024786340343E067-1103
chr78634146586341580E06719
chr78634238486342434E067938
chr78634444686344496E0673000
chr78634454986344599E0673103
chr78634510186345151E0673655
chr78634739686347446E0675950
chr78634785486347955E0676408
chr78635305886353168E06711612
chr78637592986376043E06734483
chr78637607486376485E06734628
chr78637699386377033E06735547
chr78637709186377387E06735645
chr78637740886377894E06735962
chr78637806786378119E06736621
chr78637817386378245E06736727
chr78638037786380469E06738931
chr78638057186380621E06739125
chr78638092186380961E06739475
chr78638239786382441E06740951
chr78638942286389472E06747976
chr78629256986292619E068-48827
chr78629268486292734E068-48712
chr78629388986294056E068-47390
chr78629452786294581E068-46865
chr78629502486295277E068-46169
chr78629643986296613E068-44833
chr78629709486297456E068-43990
chr78629750286297572E068-43874
chr78629774086297918E068-43528
chr78629843686298508E068-42938
chr78629922386299303E068-42143
chr78630456986304960E068-36486
chr78630500086305175E068-36271
chr78630526286305642E068-35804
chr78632100686321056E068-20390
chr78632423586324371E068-17075
chr78632734586327403E068-14043
chr78632746386327709E068-13737
chr78632806186328226E068-13220
chr78633477686334850E068-6596
chr78633525886335355E068-6091
chr78633565786335751E068-5695
chr78633577586335841E068-5605
chr78633593286335997E068-5449
chr78633620886336487E068-4959
chr78633661886336759E068-4687
chr78633682486337035E068-4411
chr78633709586337172E068-4274
chr78633724986337315E068-4131
chr78633735186338175E068-3271
chr78633842886338485E068-2961
chr78634024786340343E068-1103
chr78634444686344496E0683000
chr78634454986344599E0683103
chr78634785486347955E0686408
chr78635464886354698E06813202
chr78635494386355035E06813497
chr78636729986367349E06825853
chr78637592986376043E06834483
chr78637607486376485E06834628
chr78637740886377894E06835962
chr78637806786378119E06836621
chr78637817386378245E06836727
chr78637833386378449E06836887
chr78637859386379434E06837147
chr78638942286389472E06847976
chr78638970186389905E06848255
chr78629256986292619E069-48827
chr78629268486292734E069-48712
chr78629643986296613E069-44833
chr78629709486297456E069-43990
chr78629750286297572E069-43874
chr78629774086297918E069-43528
chr78629843686298508E069-42938
chr78632404686324136E069-17310
chr78633477686334850E069-6596
chr78633525886335355E069-6091
chr78633565786335751E069-5695
chr78633577586335841E069-5605
chr78633593286335997E069-5449
chr78633620886336487E069-4959
chr78633661886336759E069-4687
chr78633682486337035E069-4411
chr78633709586337172E069-4274
chr78633724986337315E069-4131
chr78633735186338175E069-3271
chr78633842886338485E069-2961
chr78633860286338668E069-2778
chr78634146586341580E06919
chr78634238486342434E069938
chr78634265486342704E0691208
chr78634785486347955E0696408
chr78635305886353168E06911612
chr78637377986374325E06932333
chr78637444086374649E06932994
chr78637592986376043E06934483
chr78637607486376485E06934628
chr78637699386377033E06935547
chr78637709186377387E06935645
chr78633577586335841E070-5605
chr78633593286335997E070-5449
chr78633620886336487E070-4959
chr78633661886336759E070-4687
chr78633682486337035E070-4411
chr78633709586337172E070-4274
chr78633724986337315E070-4131
chr78633735186338175E070-3271
chr78633842886338485E070-2961
chr78633860286338668E070-2778
chr78629256986292619E071-48827
chr78629268486292734E071-48712
chr78629388986294056E071-47390
chr78629452786294581E071-46865
chr78629502486295277E071-46169
chr78629643986296613E071-44833
chr78629709486297456E071-43990
chr78629750286297572E071-43874
chr78629774086297918E071-43528
chr78629843686298508E071-42938
chr78629922386299303E071-42143
chr78629981586299865E071-41581
chr78632100686321056E071-20390
chr78632734586327403E071-14043
chr78632746386327709E071-13737
chr78633477686334850E071-6596
chr78633525886335355E071-6091
chr78633565786335751E071-5695
chr78633577586335841E071-5605
chr78633593286335997E071-5449
chr78633620886336487E071-4959
chr78633661886336759E071-4687
chr78633682486337035E071-4411
chr78633709586337172E071-4274
chr78633724986337315E071-4131
chr78633735186338175E071-3271
chr78633842886338485E071-2961
chr78633860286338668E071-2778
chr78634018786340237E071-1209
chr78634024786340343E071-1103
chr78634739686347446E0715950
chr78635305886353168E07111612
chr78636314186363464E07121695
chr78636729986367349E07125853
chr78636753586367884E07126089
chr78637444086374649E07132994
chr78637468286374924E07133236
chr78637572186375811E07134275
chr78637592986376043E07134483
chr78637607486376485E07134628
chr78637699386377033E07135547
chr78637709186377387E07135645
chr78638455986384627E07143113
chr78638466986384729E07143223
chr78638490486384973E07143458
chr78629256986292619E072-48827
chr78629268486292734E072-48712
chr78629388986294056E072-47390
chr78629452786294581E072-46865
chr78629502486295277E072-46169
chr78629643986296613E072-44833
chr78629709486297456E072-43990
chr78629750286297572E072-43874
chr78629774086297918E072-43528
chr78629843686298508E072-42938
chr78629922386299303E072-42143
chr78629981586299865E072-41581
chr78630456986304960E072-36486
chr78633565786335751E072-5695
chr78633577586335841E072-5605
chr78633593286335997E072-5449
chr78633620886336487E072-4959
chr78633661886336759E072-4687
chr78633682486337035E072-4411
chr78633709586337172E072-4274
chr78633724986337315E072-4131
chr78633735186338175E072-3271
chr78633842886338485E072-2961
chr78633860286338668E072-2778
chr78634265486342704E0721208
chr78634648286346617E0725036
chr78634671286346778E0725266
chr78634739686347446E0725950
chr78634785486347955E0726408
chr78634982186349875E0728375
chr78634997686350026E0728530
chr78635016286350212E0728716
chr78635026086350391E0728814
chr78636729986367349E07225853
chr78637607486376485E07234628
chr78637699386377033E07235547
chr78637709186377387E07235645
chr78637740886377894E07235962
chr78637806786378119E07236621
chr78637817386378245E07236727
chr78637833386378449E07236887
chr78637859386379434E07237147
chr78638417986384229E07242733
chr78638426686384326E07242820
chr78638455986384627E07243113
chr78638466986384729E07243223
chr78638970186389905E07248255
chr78629388986294056E073-47390
chr78629643986296613E073-44833
chr78629709486297456E073-43990
chr78629750286297572E073-43874
chr78629774086297918E073-43528
chr78629843686298508E073-42938
chr78633565786335751E073-5695
chr78633577586335841E073-5605
chr78633593286335997E073-5449
chr78633620886336487E073-4959
chr78633661886336759E073-4687
chr78633682486337035E073-4411
chr78633709586337172E073-4274
chr78633724986337315E073-4131
chr78633735186338175E073-3271
chr78633842886338485E073-2961
chr78633860286338668E073-2778
chr78636753586367884E07326089
chr78637833386378449E07336887
chr78638942286389472E07347976
chr78629256986292619E074-48827
chr78629268486292734E074-48712
chr78629388986294056E074-47390
chr78629452786294581E074-46865
chr78629502486295277E074-46169
chr78629643986296613E074-44833
chr78629709486297456E074-43990
chr78629750286297572E074-43874
chr78629774086297918E074-43528
chr78629843686298508E074-42938
chr78629922386299303E074-42143
chr78629981586299865E074-41581
chr78630357186303627E074-37819
chr78630456986304960E074-36486
chr78631950586319555E074-21891
chr78631956086319600E074-21846
chr78632806186328226E074-13220
chr78633159686331650E074-9796
chr78633170786331765E074-9681
chr78633565786335751E074-5695
chr78633577586335841E074-5605
chr78633593286335997E074-5449
chr78633620886336487E074-4959
chr78633661886336759E074-4687
chr78633682486337035E074-4411
chr78633709586337172E074-4274
chr78633724986337315E074-4131
chr78633735186338175E074-3271
chr78633842886338485E074-2961
chr78633860286338668E074-2778
chr78634238486342434E074938
chr78634265486342704E0741208
chr78634739686347446E0745950
chr78634785486347955E0746408
chr78634982186349875E0748375
chr78634997686350026E0748530
chr78635016286350212E0748716
chr78635026086350391E0748814
chr78636729986367349E07425853
chr78637377986374325E07432333
chr78637444086374649E07432994
chr78637572186375811E07434275
chr78637592986376043E07434483
chr78637607486376485E07434628
chr78637699386377033E07435547
chr78637709186377387E07435645
chr78637859386379434E07437147
chr78637949386379549E07438047
chr78637957386380227E07438127
chr78638037786380469E07438931
chr78638057186380621E07439125
chr78638092186380961E07439475
chr78638417986384229E07442733
chr78638426686384326E07442820
chr78638455986384627E07443113
chr78630456986304960E081-36486
chr78633477686334850E081-6596
chr78633565786335751E081-5695
chr78633577586335841E081-5605
chr78633593286335997E081-5449
chr78633682486337035E081-4411
chr78633709586337172E081-4274
chr78633724986337315E081-4131
chr78633735186338175E081-3271
chr78633842886338485E081-2961
chr78637699386377033E08135547
chr78637709186377387E08135645
chr78637740886377894E08135962
chr78637806786378119E08136621
chr78637817386378245E08136727
chr78637833386378449E08136887
chr78637859386379434E08137147
chr78637957386380227E08138127
chr78638037786380469E08138931
chr78638057186380621E08139125
chr78633565786335751E082-5695
chr78633577586335841E082-5605
chr78633593286335997E082-5449
chr78637709186377387E08235645
chr78637949386379549E08238047