rs2226615

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0167 (5016/29958,GnomAD)
A=0141 (4133/29118,TOPMED)
A=0160 (803/5008,1000G)
A=0240 (924/3854,ALSPAC)
A=0224 (832/3708,TWINSUK)

Position: chr11:76245304 (GRCh38.p7) (11q13.5)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 47 Enhancers around

Promoter: 23 Promoters around

Sequence Name	Change(s)
GRCh38.p7 chr 11	NC_000011.10:g.76245304G>A
GRCh37.p13 chr 11	NC_000011.9:g.75956348G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.970	A=0.030
1000Genomes	American	Sub	694	G=0.880	A=0.120
1000Genomes	East Asian	Sub	1008	G=0.827	A=0.173
1000Genomes	Europe	Sub	1006	G=0.791	A=0.209
1000Genomes	Global	Study-wide	5008	G=0.840	A=0.160
1000Genomes	South Asian	Sub	978	G=0.690	A=0.310
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.760	A=0.240
The Genome Aggregation Database	African	Sub	8730	G=0.940	A=0.060
The Genome Aggregation Database	American	Sub	834	G=0.840	A=0.160
The Genome Aggregation Database	East Asian	Sub	1618	G=0.840	A=0.160
The Genome Aggregation Database	Europe	Sub	18474	G=0.782	A=0.217
The Genome Aggregation Database	Global	Study-wide	29958	G=0.832	A=0.167
The Genome Aggregation Database	Other	Sub	302	G=0.720	A=0.280
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.858	A=0.141
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.776	A=0.224

PMID	Title	Author	Journal
21314694	Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.	Kendler KS	Alcohol Clin Exp Res

SNP ID	p-value	Traits	Study
rs2226615	0.000336	alcohol dependence	21314694

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

There is no significant Hi-C chromatin interaction data for this SNP.

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr11	75974021	75974075	E067	17673
chr11	75974374	75974556	E067	18026
chr11	75974736	75975113	E067	18388
chr11	75927581	75927924	E069	-28424
chr11	75927986	75928089	E069	-28259
chr11	75944311	75944550	E069	-11798
chr11	75944586	75944657	E069	-11691
chr11	75964474	75964749	E069	8126
chr11	75964844	75964894	E069	8496
chr11	75965009	75965087	E069	8661
chr11	75974021	75974075	E069	17673
chr11	75974374	75974556	E069	18026
chr11	75974736	75975113	E069	18388
chr11	75980340	75982338	E070	23992
chr11	75927027	75927262	E071	-29086
chr11	75927309	75927531	E071	-28817
chr11	75927581	75927924	E071	-28424
chr11	75974021	75974075	E071	17673
chr11	75974374	75974556	E071	18026
chr11	75974736	75975113	E071	18388
chr11	75964474	75964749	E072	8126
chr11	75964844	75964894	E072	8496
chr11	75974021	75974075	E072	17673
chr11	75974374	75974556	E072	18026
chr11	75974736	75975113	E072	18388
chr11	75973577	75973632	E074	17229
chr11	75974021	75974075	E074	17673
chr11	75974374	75974556	E074	18026
chr11	75974736	75975113	E074	18388
chr11	75915130	75915229	E081	-41119
chr11	75915231	75915292	E081	-41056
chr11	75915370	75915440	E081	-40908
chr11	75954887	75955130	E081	-1218
chr11	75967503	75967728	E081	11155
chr11	75967765	75968075	E081	11417
chr11	75968151	75968433	E081	11803
chr11	75968447	75968802	E081	12099
chr11	75971114	75971179	E081	14766
chr11	75971486	75971584	E081	15138
chr11	75971674	75971849	E081	15326
chr11	75977907	75978021	E081	21559
chr11	75978112	75978277	E081	21764
chr11	75978323	75978399	E081	21975
chr11	75978415	75978480	E081	22067
chr11	75978580	75979071	E081	22232
chr11	75979130	75979305	E081	22782
chr11	75954096	75954177	E082	-2171

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr11	75916241	75918245	E067	-38103
chr11	75918321	75923153	E067	-33195
chr11	75944672	75948738	E067	-7610
chr11	75916241	75918245	E068	-38103
chr11	75918321	75923153	E068	-33195
chr11	75944672	75948738	E068	-7610
chr11	75918321	75923153	E069	-33195
chr11	75944672	75948738	E069	-7610
chr11	75944672	75948738	E070	-7610
chr11	75918321	75923153	E071	-33195
chr11	75944672	75948738	E071	-7610
chr11	75918321	75923153	E072	-33195
chr11	75944672	75948738	E072	-7610
chr11	75916241	75918245	E073	-38103
chr11	75918321	75923153	E073	-33195
chr11	75944672	75948738	E073	-7610
chr11	75916241	75918245	E074	-38103
chr11	75918321	75923153	E074	-33195
chr11	75944672	75948738	E074	-7610
chr11	75944672	75948738	E081	-7610
chr11	75916241	75918245	E082	-38103
chr11	75918321	75923153	E082	-33195
chr11	75944672	75948738	E082	-7610