rs2237547

Homo sapiens
A>C / A>G
GRM3 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0405 (12092/29848,GnomAD)
G=0393 (1970/5008,1000G)
G=0257 (992/3854,ALSPAC)
G=0270 (1003/3708,TWINSUK)
chr7:86718721 (GRCh38.p7) (7q21.12)
AD
GWASdb2
2   publication(s)
See rs on genome
2 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.86718721A>C
GRCh38.p7 chr 7NC_000007.14:g.86718721A>G
GRCh37.p13 chr 7NC_000007.13:g.86348037A>C
GRCh37.p13 chr 7NC_000007.13:g.86348037A>G

Gene: GRM3, glutamate metabotropic receptor 3(plus strand)

Molecule type Change Amino acid[Codon] SO Term
GRM3 transcript variant 1NM_000840.2:c.N/AIntron Variant
GRM3 transcript variant X1XM_011516088.1:c.N/AIntron Variant
GRM3 transcript variant X2XM_017012073.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.226G=0.774
1000GenomesAmericanSub694A=0.740G=0.260
1000GenomesEast AsianSub1008A=0.772G=0.228
1000GenomesEuropeSub1006A=0.714G=0.286
1000GenomesGlobalStudy-wide5008A=0.607G=0.393
1000GenomesSouth AsianSub978A=0.750G=0.250
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.743G=0.257
The Genome Aggregation DatabaseAfricanSub8700A=0.299G=0.701
The Genome Aggregation DatabaseAmericanSub832A=0.760G=0.240
The Genome Aggregation DatabaseEast AsianSub1570A=0.799G=0.201
The Genome Aggregation DatabaseEuropeSub18444A=0.709G=0.290
The Genome Aggregation DatabaseGlobalStudy-wide29848A=0.594G=0.405
The Genome Aggregation DatabaseOtherSub302A=0.600G=0.400
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.730G=0.270
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res
19156168Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.Need ACEur J Hum Genet

P-Value

SNP ID p-value Traits Study
rs22375470.000552alcohol dependence21314694

eQTL of rs2237547 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2237547 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7126745147126745201E07048275
chr7126745341126745404E07048469