rs2237781

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

GRM8 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0054 (1629/29962,GnomAD)
A=0045 (1309/29118,TOPMED)
A=0078 (393/5008,1000G)

Position: chr7:127034996 (GRCh38.p7) (7q31.33)

Phenotype: ND

Dataset:

GWASdb2

Publications: 4 publication(s)

Genomic View: See rs on genome

Enhancer: 0 Enhancer around

Promoter: 0 Promoter around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 7	NC_000007.14:g.127034996G>A
GRCh37.p13 chr 7	NC_000007.13:g.126675050G>A
GRM8 RefSeqGene	NG_029532.1:g.222379C>T

Gene: GRM8, glutamate metabotropic receptor 8(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
GRM8 transcript variant 1	NM_000845.2:c.	N/A	Intron Variant
GRM8 transcript variant 2	NM_001127323.1:c.	N/A	Intron Variant
GRM8 transcript variant 3	NR_028041.1:n.	N/A	Intron Variant
GRM8 transcript variant X2	XM_006715938.3:c.	N/A	Intron Variant
GRM8 transcript variant X1	XM_011516091.1:c.	N/A	Intron Variant
GRM8 transcript variant X3	XM_011516092.2:c.	N/A	Intron Variant
GRM8 transcript variant X5	XM_011516094.1:c.	N/A	Intron Variant
GRM8 transcript variant X6	XM_011516095.2:c.	N/A	Intron Variant
GRM8 transcript variant X12	XM_011516101.2:c.	N/A	Intron Variant
GRM8 transcript variant X13	XM_011516102.2:c.	N/A	Intron Variant
GRM8 transcript variant X14	XM_011516103.2:c.	N/A	Intron Variant
GRM8 transcript variant X4	XM_017012074.1:c.	N/A	Intron Variant
GRM8 transcript variant X7	XM_017012075.1:c.	N/A	Intron Variant
GRM8 transcript variant X8	XM_017012076.1:c.	N/A	Intron Variant
GRM8 transcript variant X9	XM_017012077.1:c.	N/A	Intron Variant
GRM8 transcript variant X10	XM_017012078.1:c.	N/A	Intron Variant
GRM8 transcript variant X11	XM_017012079.1:c.	N/A	Intron Variant
GRM8 transcript variant X17	XM_011516108.2:c.	N/A	Genic Upstream Transcript Variant
GRM8 transcript variant X15	XM_017012080.1:c.	N/A	Genic Upstream Transcript Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.970	A=0.030
1000Genomes	American	Sub	694	G=0.940	A=0.060
1000Genomes	East Asian	Sub	1008	G=0.874	A=0.126
1000Genomes	Europe	Sub	1006	G=0.954	A=0.046
1000Genomes	Global	Study-wide	5008	G=0.922	A=0.078
1000Genomes	South Asian	Sub	978	G=0.860	A=0.140
The Genome Aggregation Database	African	Sub	8732	G=0.975	A=0.025
The Genome Aggregation Database	American	Sub	838	G=0.920	A=0.080
The Genome Aggregation Database	East Asian	Sub	1606	G=0.873	A=0.127
The Genome Aggregation Database	Europe	Sub	18484	G=0.939	A=0.060
The Genome Aggregation Database	Global	Study-wide	29962	G=0.945	A=0.054
The Genome Aggregation Database	Other	Sub	302	G=0.910	A=0.090
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.955	A=0.045

PMID	Title	Author	Journal
19268276	Genome-wide association study of smoking initiation and current smoking.	Vink JM	Am J Hum Genet
22719919	Glutamate and synaptic plasticity systems and smoking behavior: results from a genetic association study.	dos Santos VA	PLoS One
27181159	A genetic variant in proximity to the gene LYPLAL1 is associated with lower hunger feelings and increased weight loss following Roux-en-Y gastric bypass surgery.	Bandstein M	Scand J Gastroenterol
25542302	Role of genetic variants in ADIPOQ in human eating behavior.	Rohde K	Genes Nutr

P-Value

SNP ID	p-value	Traits	Study
rs2237781	4.02E-05	nicotine smoking	19268276

eQTL of rs2237781 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs2237781 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.