rs224938

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0491 (14695/29924,GnomAD)
T=0451 (13136/29118,TOPMED)
C==0454 (2273/5008,1000G)
T=0492 (1897/3854,ALSPAC)
T=0496 (1840/3708,TWINSUK)
chr5:82421357 (GRCh38.p7) (5q14.2)
OD
GWASdb2
1   publication(s)
See rs on genome
6 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.82421357C>T
GRCh37.p13 chr 5NC_000005.9:g.81717176C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.644T=0.356
1000GenomesAmericanSub694C=0.460T=0.540
1000GenomesEast AsianSub1008C=0.335T=0.665
1000GenomesEuropeSub1006C=0.509T=0.491
1000GenomesGlobalStudy-wide5008C=0.454T=0.546
1000GenomesSouth AsianSub978C=0.260T=0.740
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.508T=0.492
The Genome Aggregation DatabaseAfricanSub8696C=0.624T=0.376
The Genome Aggregation DatabaseAmericanSub838C=0.380T=0.620
The Genome Aggregation DatabaseEast AsianSub1616C=0.324T=0.676
The Genome Aggregation DatabaseEuropeSub18474C=0.477T=0.523
The Genome Aggregation DatabaseGlobalStudy-wide29924C=0.508T=0.491
The Genome Aggregation DatabaseOtherSub300C=0.490T=0.510
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.548T=0.451
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.504T=0.496
PMID Title Author Journal
23183491Genome-wide association study identifies a potent locus associated with human opioid sensitivity.Nishizawa DMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs2249389.6E-07Opioid sensitivity23183491

eQTL of rs224938 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs224938 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr58169232081693304E068-23872
chr58167149781672593E070-44583
chr58176604981766252E07048873
chr58169232081693304E071-23872
chr58173190881732545E08114732
chr58174063581740880E08123459