rs2268888

Homo sapiens
C>T
DPP4 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0050 (1499/29992,GnomAD)
T=0037 (1090/29118,TOPMED)
T=0117 (587/5008,1000G)
T=0014 (54/3854,ALSPAC)
T=0015 (55/3708,TWINSUK)
chr2:162028940 (GRCh38.p7) (2q24.2)
AD
GWASdb2
1   publication(s)
See rs on genome
62 Enhancers around
8 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.162028940C>T
GRCh37.p13 chr 2NC_000002.11:g.162885450C>T

Gene: DPP4, dipeptidyl peptidase 4(minus strand)

Molecule type Change Amino acid[Codon] SO Term
DPP4 transcriptNM_001935.3:c.N/AIntron Variant
DPP4 transcript variant X1XM_005246371.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.944T=0.056
1000GenomesAmericanSub694C=0.990T=0.010
1000GenomesEast AsianSub1008C=0.737T=0.263
1000GenomesEuropeSub1006C=0.973T=0.027
1000GenomesGlobalStudy-wide5008C=0.883T=0.117
1000GenomesSouth AsianSub978C=0.780T=0.220
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.986T=0.014
The Genome Aggregation DatabaseAfricanSub8724C=0.943T=0.057
The Genome Aggregation DatabaseAmericanSub838C=0.980T=0.020
The Genome Aggregation DatabaseEast AsianSub1622C=0.718T=0.282
The Genome Aggregation DatabaseEuropeSub18506C=0.972T=0.027
The Genome Aggregation DatabaseGlobalStudy-wide29992C=0.950T=0.050
The Genome Aggregation DatabaseOtherSub302C=0.960T=0.040
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.962T=0.037
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.985T=0.015
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs22688880.00079alcohol dependence20201924

eQTL of rs2268888 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2268888 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2162854429162854485E067-30965
chr2162854760162855399E067-30051
chr2162858246162858347E069-27103
chr2162858540162858638E069-26812
chr2162858683162859181E069-26269
chr2162885667162885762E069217
chr2162885802162886415E069352
chr2162852137162852410E070-33040
chr2162858540162858638E070-26812
chr2162858683162859181E070-26269
chr2162891229162891350E0705779
chr2162885802162886415E071352
chr2162885667162885762E073217
chr2162885802162886415E073352
chr2162858683162859181E074-26269
chr2162859215162859791E074-25659
chr2162869238162869476E074-15974
chr2162869795162869864E074-15586
chr2162848647162848785E081-36665
chr2162848883162848950E081-36500
chr2162849611162850030E081-35420
chr2162852137162852410E081-33040
chr2162852411162852490E081-32960
chr2162852622162852672E081-32778
chr2162854429162854485E081-30965
chr2162854760162855399E081-30051
chr2162855474162855615E081-29835
chr2162855823162856342E081-29108
chr2162856497162856779E081-28671
chr2162856847162857521E081-27929
chr2162858246162858347E081-27103
chr2162858540162858638E081-26812
chr2162858683162859181E081-26269
chr2162859215162859791E081-25659
chr2162860043162860093E081-25357
chr2162860692162860803E081-24647
chr2162861086162861397E081-24053
chr2162861484162861727E081-23723
chr2162865753162865813E081-19637
chr2162882011162882505E081-2945
chr2162885802162886415E081352
chr2162848647162848785E082-36665
chr2162848883162848950E082-36500
chr2162852411162852490E082-32960
chr2162852622162852672E082-32778
chr2162854429162854485E082-30965
chr2162854760162855399E082-30051
chr2162855474162855615E082-29835
chr2162855823162856342E082-29108
chr2162856497162856779E082-28671
chr2162856847162857521E082-27929
chr2162858246162858347E082-27103
chr2162858540162858638E082-26812
chr2162858683162859181E082-26269
chr2162859215162859791E082-25659
chr2162860043162860093E082-25357
chr2162860692162860803E082-24647
chr2162874612162874662E082-10788
chr2162874967162875250E082-10200
chr2162876143162876255E082-9195
chr2162878921162879147E082-6303
chr2162885667162885762E082217








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr2162929701162931388E06744251
chr2162929701162931388E06944251
chr2162929701162931388E07144251
chr2162929701162931388E07244251
chr2162929701162931388E07344251
chr2162929701162931388E07444251
chr2162873824162873907E082-11543
chr2162929701162931388E08244251