rs2284981

Homo sapiens
G>C
ZNF225 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0313 (9399/29946,GnomAD)
G==0374 (10892/29118,TOPMED)
G==0425 (2130/5008,1000G)
G==0150 (577/3854,ALSPAC)
G==0159 (589/3708,TWINSUK)
chr19:44129405 (GRCh38.p7) (19q13.31)
AD
GWASdb2
1   publication(s)
See rs on genome
29 Enhancers around
60 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 19NC_000019.10:g.44129405G>C
GRCh37.p13 chr 19NC_000019.9:g.44633558G>C

Gene: ZNF225, zinc finger protein 225(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ZNF225 transcript variant 2NM_001321685.1:c.N/AIntron Variant
ZNF225 transcript variant 1NM_013362.3:c.N/AIntron Variant
ZNF225 transcript variant X3XM_005259223.3:c.N/AIntron Variant
ZNF225 transcript variant X1XM_011527285.2:c.N/AIntron Variant
ZNF225 transcript variant X2XM_011527286.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.625C=0.375
1000GenomesAmericanSub694G=0.460C=0.540
1000GenomesEast AsianSub1008G=0.499C=0.501
1000GenomesEuropeSub1006G=0.176C=0.824
1000GenomesGlobalStudy-wide5008G=0.425C=0.575
1000GenomesSouth AsianSub978G=0.310C=0.690
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.150C=0.850
The Genome Aggregation DatabaseAfricanSub8710G=0.567C=0.433
The Genome Aggregation DatabaseAmericanSub838G=0.480C=0.520
The Genome Aggregation DatabaseEast AsianSub1614G=0.460C=0.540
The Genome Aggregation DatabaseEuropeSub18482G=0.176C=0.823
The Genome Aggregation DatabaseGlobalStudy-wide29946G=0.313C=0.686
The Genome Aggregation DatabaseOtherSub302G=0.170C=0.830
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.374C=0.625
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.159C=0.841
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs22849818.45E-05alcohol consumption23743675

eQTL of rs2284981 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr19:44633558ZNF284ENSG00000186026.6G>C8.0274e-457261Cerebellar_Hemisphere

meQTL of rs2284981 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr194467075844670818E06737200
chr194467093344671011E06737375
chr194467104944671115E06737491
chr194461888344619034E068-14524
chr194467075844670818E06837200
chr194467093344671011E06837375
chr194460014844600194E069-33364
chr194460014844600194E070-33364
chr194461888344619034E070-14524
chr194461903744619091E070-14467
chr194461912544619165E070-14393
chr194467075844670818E07037200
chr194467093344671011E07037375
chr194467104944671115E07037491
chr194467187644671938E07038318
chr194461888344619034E071-14524
chr194467075844670818E07137200
chr194467075844670818E07237200
chr194467093344671011E07237375
chr194467075844670818E07437200
chr194467093344671011E07437375
chr194467187644671938E07438318
chr194467075844670818E08137200
chr194467093344671011E08137375
chr194467104944671115E08137491
chr194467187644671938E08138318
chr194460081644600930E082-32628
chr194467093344671011E08237375
chr194467104944671115E08237491









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr194459804744599722E067-33836
chr194461592544616789E067-16769
chr194461680644618482E067-15076
chr194464488144646741E06711323
chr194466849844670041E06734940
chr194459781244597885E068-35673
chr194459793544597989E068-35569
chr194459804744599722E068-33836
chr194461578744615827E068-17731
chr194461592544616789E068-16769
chr194461680644618482E068-15076
chr194464474344644803E06811185
chr194464488144646741E06811323
chr194466849844670041E06834940
chr194459804744599722E069-33836
chr194461578744615827E069-17731
chr194461592544616789E069-16769
chr194461680644618482E069-15076
chr194464488144646741E06911323
chr194466849844670041E06934940
chr194459804744599722E070-33836
chr194461592544616789E070-16769
chr194461680644618482E070-15076
chr194464474344644803E07011185
chr194464488144646741E07011323
chr194466849844670041E07034940
chr194459804744599722E071-33836
chr194461578744615827E071-17731
chr194461592544616789E071-16769
chr194461680644618482E071-15076
chr194464474344644803E07111185
chr194464488144646741E07111323
chr194466849844670041E07134940
chr194459804744599722E072-33836
chr194461592544616789E072-16769
chr194461680644618482E072-15076
chr194464474344644803E07211185
chr194464488144646741E07211323
chr194466849844670041E07234940
chr194459804744599722E073-33836
chr194461592544616789E073-16769
chr194461680644618482E073-15076
chr194464488144646741E07311323
chr194466849844670041E07334940
chr194459804744599722E074-33836
chr194461592544616789E074-16769
chr194461680644618482E074-15076
chr194464488144646741E07411323
chr194466849844670041E07434940
chr194459804744599722E081-33836
chr194461592544616789E081-16769
chr194461680644618482E081-15076
chr194464488144646741E08111323
chr194466849844670041E08134940
chr194459804744599722E082-33836
chr194461592544616789E082-16769
chr194461680644618482E082-15076
chr194464474344644803E08211185
chr194464488144646741E08211323
chr194466849844670041E08234940