SNP Detail Info-rs2345955

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 2	NC_000002.12:g.46093741C>T
GRCh37.p13 chr 2	NC_000002.11:g.46320880C>T

Gene: PRKCE, protein kinase C epsilon(plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
PRKCE transcript	NM_005400.2:c.	N/A	Intron Variant
PRKCE transcript variant X1	XM_005264428.1:c.	N/A	Intron Variant
PRKCE transcript variant X19	XM_006712050.3:c.	N/A	Intron Variant
PRKCE transcript variant X3	XM_011532971.2:c.	N/A	Intron Variant
PRKCE transcript variant X4	XM_011532975.2:c.	N/A	Intron Variant
PRKCE transcript variant X6	XM_011532978.1:c.	N/A	Intron Variant
PRKCE transcript variant X10	XM_011532980.2:c.	N/A	Intron Variant
PRKCE transcript variant X12	XM_011532981.2:c.	N/A	Intron Variant
PRKCE transcript variant X13	XM_011532982.1:c.	N/A	Intron Variant
PRKCE transcript variant X20	XM_011532983.2:c.	N/A	Intron Variant
PRKCE transcript variant X2	XM_017004486.1:c.	N/A	Intron Variant
PRKCE transcript variant X5	XM_017004487.1:c.	N/A	Intron Variant
PRKCE transcript variant X7	XM_017004488.1:c.	N/A	Intron Variant
PRKCE transcript variant X8	XM_017004489.1:c.	N/A	Intron Variant
PRKCE transcript variant X9	XM_017004490.1:c.	N/A	Intron Variant
PRKCE transcript variant X11	XM_017004491.1:c.	N/A	Intron Variant
PRKCE transcript variant X14	XM_005264431.3:c.	N/A	Genic Downstream Transcript Variant
PRKCE transcript variant X15	XM_017004492.1:c.	N/A	Genic Downstream Transcript Variant
PRKCE transcript variant X19	XR_001738846.1:n.	N/A	Genic Downstream Transcript Variant
PRKCE transcript variant X18	XR_939695.2:n.	N/A	Genic Downstream Transcript Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	C=0.528	T=0.472
1000Genomes	American	Sub	694	C=0.250	T=0.750
1000Genomes	East Asian	Sub	1008	C=0.155	T=0.845
1000Genomes	Europe	Sub	1006	C=0.191	T=0.809
1000Genomes	Global	Study-wide	5008	C=0.297	T=0.703
1000Genomes	South Asian	Sub	978	C=0.280	T=0.720
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	C=0.207	T=0.793
The Genome Aggregation Database	African	Sub	8648	C=0.475	T=0.525
The Genome Aggregation Database	American	Sub	836	C=0.160	T=0.840
The Genome Aggregation Database	East Asian	Sub	1608	C=0.159	T=0.841
The Genome Aggregation Database	Europe	Sub	18400	C=0.189	T=0.810
The Genome Aggregation Database	Global	Study-wide	29792	C=0.270	T=0.729
The Genome Aggregation Database	Other	Sub	300	C=0.290	T=0.710
Trans-Omics for Precision Medicine	Global	Study-wide	29116	C=0.313	T=0.686
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	C=0.201	T=0.799

PMID	Title	Author	Journal
19268276	Genome-wide association study of smoking initiation and current smoking.	Vink JM	Am J Hum Genet

P-Value

SNP ID	p-value	Traits	Study
rs2345955	0.00082	nicotine smoking	19268276

eQTL of rs2345955 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
Chr2:46320880	SRBD1	ENSG00000068784.8	C>T	6.4017e-3	481576	Nucleus_accumbens_basal_ganglia

meQTL of rs2345955 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr2	46290121	46290514	E067	-30366
chr2	46369822	46369992	E067	48942
chr2	46370110	46370281	E067	49230
chr2	46370381	46370741	E067	49501
chr2	46285274	46285324	E068	-35556
chr2	46300404	46301187	E068	-19693
chr2	46325738	46326159	E068	4858
chr2	46369822	46369992	E068	48942
chr2	46370110	46370281	E068	49230
chr2	46370381	46370741	E068	49501
chr2	46290121	46290514	E069	-30366
chr2	46290566	46290710	E069	-30170
chr2	46324713	46325421	E069	3833
chr2	46370110	46370281	E069	49230
chr2	46370381	46370741	E069	49501
chr2	46289518	46289654	E071	-31226
chr2	46289715	46289775	E071	-31105
chr2	46290121	46290514	E071	-30366
chr2	46290566	46290710	E071	-30170
chr2	46300404	46301187	E071	-19693
chr2	46342342	46342472	E071	21462
chr2	46346103	46346943	E071	25223
chr2	46369608	46369760	E071	48728
chr2	46369822	46369992	E071	48942
chr2	46370110	46370281	E071	49230
chr2	46370381	46370741	E071	49501
chr2	46285274	46285324	E072	-35556
chr2	46285443	46285524	E072	-35356
chr2	46369608	46369760	E072	48728
chr2	46369822	46369992	E072	48942
chr2	46370110	46370281	E072	49230
chr2	46370381	46370741	E072	49501
chr2	46285274	46285324	E073	-35556
chr2	46285443	46285524	E073	-35356
chr2	46299647	46299942	E073	-20938
chr2	46300404	46301187	E073	-19693
chr2	46361570	46362099	E073	40690
chr2	46370110	46370281	E073	49230
chr2	46370381	46370741	E073	49501
chr2	46285274	46285324	E074	-35556
chr2	46285443	46285524	E074	-35356
chr2	46290121	46290514	E074	-30366
chr2	46310391	46310501	E074	-10379
chr2	46325738	46326159	E074	4858
chr2	46326457	46326511	E074	5577
chr2	46342342	46342472	E074	21462
chr2	46369608	46369760	E074	48728
chr2	46369822	46369992	E074	48942
chr2	46370110	46370281	E074	49230
chr2	46370381	46370741	E074	49501
chr2	46343516	46343733	E081	22636
chr2	46343738	46343920	E081	22858
chr2	46343971	46344048	E081	23091
chr2	46356873	46356923	E081	35993

rs2345955

Genomic Coordinates

Gene: PRKCE, protein kinase C epsilon(plus strand)

Population Frequency

P-Value

eQTL of rs2345955 in Brain tissues (GTEx Analysis Release V7)

meQTL of rs2345955 in Fetal Brain

Genomic View

Chromatin Interaction

Enhancer Annotation (GRCh37.p13)