rs2361573

Homo sapiens
T>C / T>G
None
Check p-value
SNV (Single Nucleotide Variation)
T==0486 (14558/29914,GnomAD)
G=0481 (14022/29118,TOPMED)
G=0480 (2403/5008,1000G)
T==0434 (1674/3854,ALSPAC)
T==0421 (1562/3708,TWINSUK)
chr17:1322646 (GRCh38.p7) (17p13.3)
ND
GWASdb2
1   publication(s)
See rs on genome
77 Enhancers around
4 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 17NC_000017.11:g.1322646T>C
GRCh38.p7 chr 17NC_000017.11:g.1322646T>G
GRCh37.p13 chr 17NC_000017.10:g.1225940T>C
GRCh37.p13 chr 17NC_000017.10:g.1225940T>G
GRCh38.p7 chr 17 alt locus HSCHR17_2_CTG2NT_187613.1:g.264672T>C
GRCh38.p7 chr 17 alt locus HSCHR17_2_CTG2NT_187613.1:g.264672T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.686G=0.314
1000GenomesAmericanSub694T=0.330G=0.670
1000GenomesEast AsianSub1008T=0.530G=0.470
1000GenomesEuropeSub1006T=0.470G=0.530
1000GenomesGlobalStudy-wide5008T=0.520G=0.480
1000GenomesSouth AsianSub978T=0.470G=0.530
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.434G=0.566
The Genome Aggregation DatabaseAfricanSub8698T=0.623C=0.000
The Genome Aggregation DatabaseAmericanSub838T=0.330C=0.00,
The Genome Aggregation DatabaseEast AsianSub1616T=0.527C=0.000
The Genome Aggregation DatabaseEuropeSub18460T=0.425C=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29914T=0.486C=0.000
The Genome Aggregation DatabaseOtherSub302T=0.510C=0.00,
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.518G=0.481
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.421G=0.579
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs23615730.000103nicotine dependence17158188

eQTL of rs2361573 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr17:1225940CRKENSG00000167193.7T>G6.5377e-4-140516Anterior_cingulate_cortex

meQTL of rs2361573 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr174175507641755884E06825303
chr174177361141774156E06843838
chr174177143541772398E06941662
chr174177361141774156E06943838
chr174177420341774266E06944430
chr174177361141774156E07043838
chr174177420341774266E07044430
chr174177143541772398E07141662
chr174177346841773596E07143695
chr174177361141774156E07143838
chr174177420341774266E07144430
chr174177346841773596E07243695
chr174177361141774156E07243838
chr174177420341774266E07244430
chr174175507641755884E07325303
chr174177361141774156E07343838
chr174177420341774266E07344430
chr174177446741774517E07344694
chr174177466941774732E07344896
chr174175507641755884E07425303
chr174177361141774156E07443838
chr174177420341774266E07444430
chr174172731241727407E081-2366
chr174172747841727532E081-2241
chr174172785141728267E081-1506
chr174172833441728384E081-1389
chr174172867241729394E081-379
chr174172943641729568E081-205
chr174172967341729840E0810
chr174173606141736785E0816288
chr174173882841739076E0819055
chr174173907741740480E0819304
chr174174053841740679E08110765
chr174174676241747957E08116989
chr174174800741748162E08118234
chr174174822941748305E08118456
chr174174831141748788E08118538
chr174174889541749031E08119122
chr174174924141749310E08119468
chr174174963741749778E08119864
chr174174984341750050E08120070
chr174175009941750160E08120326
chr174175019241750252E08120419
chr174175026641750398E08120493
chr174175266041752963E08122887
chr174175298041753211E08123207
chr174175331441753354E08123541
chr174177143541772398E08141662
chr174177346841773596E08143695
chr174177361141774156E08143838
chr174177420341774266E08144430
chr174177446741774517E08144694
chr174177466941774732E08144896
chr174177491241774952E08145139
chr174177498741775037E08145214
chr174177509341775143E08145320
chr174172867241729394E082-379
chr174172943641729568E082-205
chr174172967341729840E0820
chr174172992741730027E082154
chr174173506841735136E0825295
chr174173907741740480E0829304
chr174174800741748162E08218234
chr174174822941748305E08218456
chr174174831141748788E08218538
chr174174889541749031E08219122
chr174174924141749310E08219468
chr174174963741749778E08219864
chr174174984341750050E08220070
chr174175009941750160E08220326
chr174175019241750252E08220419
chr174176867741769051E08238904
chr174177346841773596E08243695
chr174177361141774156E08243838
chr174177420341774266E08244430
chr174177446741774517E08244694
chr174177466941774732E08244896









Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr174172284041724030E068-5743
chr174172284041724030E069-5743
chr174172284041724030E071-5743
chr174172284041724030E082-5743