rs2375489

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0475 (14113/29682,GnomAD)
T==0496 (14448/29118,TOPMED)
C=0481 (2410/5008,1000G)
chr4:35515534 (GRCh38.p7) (4p15.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
14 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.35515534T>C
GRCh37.p13 chr 4NC_000004.11:g.35517156T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.483C=0.517
1000GenomesAmericanSub694T=0.460C=0.540
1000GenomesEast AsianSub1008T=0.704C=0.296
1000GenomesEuropeSub1006T=0.534C=0.466
1000GenomesGlobalStudy-wide5008T=0.519C=0.481
1000GenomesSouth AsianSub978T=0.400C=0.600
The Genome Aggregation DatabaseAfricanSub8640T=0.503C=0.497
The Genome Aggregation DatabaseAmericanSub836T=0.430C=0.570
The Genome Aggregation DatabaseEast AsianSub1602T=0.753C=0.247
The Genome Aggregation DatabaseEuropeSub18304T=0.518C=0.482
The Genome Aggregation DatabaseGlobalStudy-wide29682T=0.524C=0.475
The Genome Aggregation DatabaseOtherSub300T=0.590C=0.410
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.496C=0.503
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs23754890.000287nicotine dependence17158188

eQTL of rs2375489 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2375489 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr43552673735526787E0749581
chr43553670135536912E08219545
chr43553699835537160E08219842


Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr43552687235526986E0689716
chr43552703435527236E0689878
chr43552753335527608E06810377
chr43552687235526986E0699716
chr43552703435527236E0699878
chr43552687235526986E0719716
chr43552703435527236E0719878
chr43552753335527608E07110377
chr43552687235526986E0729716
chr43552703435527236E0729878
chr43552687235526986E0739716
chr43552703435527236E0739878
chr43552687235526986E0749716
chr43552703435527236E0749878