rs2398236

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0357 (10706/29932,GnomAD)
A==0350 (10215/29118,TOPMED)
A==0307 (1538/5008,1000G)
A==0379 (1462/3854,ALSPAC)
A==0379 (1407/3708,TWINSUK)
chr10:5289196 (GRCh38.p7) (10p15.1)
AD
GWASdb2
1   publication(s)
See rs on genome
95 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 10NC_000010.11:g.5289196A>G
GRCh37.p13 chr 10 fix patch HG871_PATCHNW_003871071.1:g.318862A>G
GRCh37.p13 chr 10NC_000010.10:g.5331159A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.286G=0.714
1000GenomesAmericanSub694A=0.460G=0.540
1000GenomesEast AsianSub1008A=0.251G=0.749
1000GenomesEuropeSub1006A=0.390G=0.610
1000GenomesGlobalStudy-wide5008A=0.307G=0.693
1000GenomesSouth AsianSub978A=0.200G=0.800
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.379G=0.621
The Genome Aggregation DatabaseAfricanSub8712A=0.305G=0.695
The Genome Aggregation DatabaseAmericanSub836A=0.450G=0.550
The Genome Aggregation DatabaseEast AsianSub1616A=0.224G=0.776
The Genome Aggregation DatabaseEuropeSub18466A=0.390G=0.609
The Genome Aggregation DatabaseGlobalStudy-wide29932A=0.357G=0.642
The Genome Aggregation DatabaseOtherSub302A=0.350G=0.650
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.350G=0.649
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.379G=0.621
PMID Title Author Journal
23691058Dosage transmission disequilibrium test (dTDT) for linkage and association detection.Zhang ZPLoS One

P-Value

SNP ID p-value Traits Study
rs23982369.07E-06alcohol dependence23691058

eQTL of rs2398236 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr10:5331159TUBAL3ENSG00000178462.7A>G1.5245e-3-115634Hippocampus

meQTL of rs2398236 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr10290440290490E067-28372
chr10290985291116E067-27746
chr10321004321089E0672142
chr10338932338982E06720070
chr10339171339221E06720309
chr10339288339338E06720426
chr10339542339638E06720680
chr10340144340306E06721282
chr10343106343831E06724244
chr10343924344003E06725062
chr10344049344318E06725187
chr10338932338982E06820070
chr10339171339221E06820309
chr10339288339338E06820426
chr10339542339638E06820680
chr10340144340306E06821282
chr10343106343831E06824244
chr10343924344003E06825062
chr10344049344318E06825187
chr10344403344453E06825541
chr10344740344858E06825878
chr10287477287640E069-31222
chr10290440290490E069-28372
chr10321004321089E0692142
chr10338932338982E06920070
chr10339171339221E06920309
chr10339288339338E06920426
chr10339542339638E06920680
chr10340144340306E06921282
chr10343106343831E06924244
chr10343924344003E06925062
chr10344049344318E06925187
chr10287923288291E070-30571
chr10288443288559E070-30303
chr10321004321089E0702142
chr10287477287640E071-31222
chr10321004321089E0712142
chr10335847336053E07116985
chr10336089336191E07117227
chr10336373336438E07117511
chr10336950336990E07118088
chr10338932338982E07120070
chr10339171339221E07120309
chr10339288339338E07120426
chr10339542339638E07120680
chr10340144340306E07121282
chr10343106343831E07124244
chr10343924344003E07125062
chr10344049344318E07125187
chr10344403344453E07125541
chr10287477287640E072-31222
chr10290440290490E072-28372
chr10321004321089E0722142
chr10328668328794E0729806
chr10338932338982E07220070
chr10339171339221E07220309
chr10339288339338E07220426
chr10339542339638E07220680
chr10340144340306E07221282
chr10343106343831E07224244
chr10343924344003E07225062
chr10344049344318E07225187
chr10344403344453E07225541
chr10339542339638E07320680
chr10340144340306E07321282
chr10343106343831E07324244
chr10287477287640E074-31222
chr10287923288291E074-30571
chr10290440290490E074-28372
chr10317286317666E074-1196
chr10321004321089E0742142
chr10335847336053E07416985
chr10336089336191E07417227
chr10336373336438E07417511
chr10338932338982E07420070
chr10339171339221E07420309
chr10339288339338E07420426
chr10339542339638E07420680
chr10340144340306E07421282
chr10343106343831E07424244
chr10343924344003E07425062
chr10344049344318E07425187
chr10344403344453E07425541
chr10344740344858E07425878
chr10287477287640E081-31222
chr10291259291444E081-27418
chr10291506291586E081-27276
chr10291655291723E081-27139
chr10291842292190E081-26672
chr10352079352249E08233217
chr10352252352502E08233390
chr10352608353131E08233746
chr10356266356354E08237404
chr10356392356451E08237530
chr10356518356595E08237656