rs2400474

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0343 (10265/29888,GnomAD)
A==0360 (10491/29118,TOPMED)
A==0396 (1985/5008,1000G)
A==0332 (1280/3854,ALSPAC)
A==0320 (1186/3708,TWINSUK)
chr8:81794204 (GRCh38.p7) (8q21.13)
AD
GWASdb2
1   publication(s)
See rs on genome
93 Enhancers around
39 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.81794204A>G
GRCh37.p13 chr 8NC_000008.10:g.82706439A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.376G=0.624
1000GenomesAmericanSub694A=0.390G=0.610
1000GenomesEast AsianSub1008A=0.597G=0.403
1000GenomesEuropeSub1006A=0.327G=0.673
1000GenomesGlobalStudy-wide5008A=0.396G=0.604
1000GenomesSouth AsianSub978A=0.290G=0.710
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.332G=0.668
The Genome Aggregation DatabaseAfricanSub8700A=0.368G=0.632
The Genome Aggregation DatabaseAmericanSub836A=0.320G=0.680
The Genome Aggregation DatabaseEast AsianSub1620A=0.629G=0.371
The Genome Aggregation DatabaseEuropeSub18432A=0.307G=0.692
The Genome Aggregation DatabaseGlobalStudy-wide29888A=0.343G=0.656
The Genome Aggregation DatabaseOtherSub300A=0.370G=0.630
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.360G=0.639
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.320G=0.680
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs24004742.16E-05alcohol consumption23743675

eQTL of rs2400474 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2400474 in Fetal Brain

Probe ID Position Gene beta p-value
cg17211192chr8:82754475SNX160.06507179835992783.6150e-27
cg27398817chr8:82754497SNX160.03859704753286651.9163e-15
cg23324259chr8:82754387SNX160.01760097898047476.9527e-14

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr88272692182727044E06720482
chr88272708482727145E06720645
chr88272739782727713E06720958
chr88275141582751459E06744976
chr88275155182751632E06745112
chr88275169382751743E06745254
chr88275176982751905E06745330
chr88275192082751978E06745481
chr88275205182752101E06745612
chr88275213682752286E06745697
chr88275242482752500E06745985
chr88275252382752586E06746084
chr88274913582749745E06842696
chr88275040382750493E06843964
chr88275055782750622E06844118
chr88275073382750913E06844294
chr88275118682751259E06844747
chr88275141582751459E06844976
chr88275155182751632E06845112
chr88275169382751743E06845254
chr88275242482752500E06845985
chr88275252382752586E06846084
chr88275264882752702E06846209
chr88275205182752101E06945612
chr88275213682752286E06945697
chr88275242482752500E06945985
chr88275252382752586E06946084
chr88275264882752702E06946209
chr88270876682709232E0702327
chr88270927582709325E0702836
chr88270935482709440E0702915
chr88273635982736422E07029920
chr88273760682737656E07031167
chr88273770482737783E07031265
chr88274913582749745E07042696
chr88272692182727044E07120482
chr88272739782727713E07120958
chr88275040382750493E07143964
chr88275055782750622E07144118
chr88275073382750913E07144294
chr88275176982751905E07145330
chr88275192082751978E07145481
chr88275205182752101E07145612
chr88275213682752286E07145697
chr88275242482752500E07145985
chr88275252382752586E07146084
chr88275264882752702E07146209
chr88269268482693377E072-13062
chr88272629482726439E07219855
chr88272692182727044E07220482
chr88272708482727145E07220645
chr88272739782727713E07220958
chr88272739782727713E07320958
chr88272692182727044E07420482
chr88275040382750493E07443964
chr88275055782750622E07444118
chr88275073382750913E07444294
chr88275118682751259E07444747
chr88275141582751459E07444976
chr88275155182751632E07445112
chr88275169382751743E07445254
chr88275176982751905E07445330
chr88275192082751978E07445481
chr88275205182752101E07445612
chr88275213682752286E07445697
chr88275242482752500E07445985
chr88275252382752586E07446084
chr88275264882752702E07446209
chr88269268482693377E081-13062
chr88274894182748991E08142502
chr88275118682751259E08144747
chr88275141582751459E08144976
chr88275155182751632E08145112
chr88275169382751743E08145254
chr88275176982751905E08145330
chr88275192082751978E08145481
chr88275205182752101E08145612
chr88275213682752286E08145697
chr88275242482752500E08145985
chr88275252382752586E08146084
chr88275264882752702E08146209
chr88269939382699447E082-6992
chr88269957982699654E082-6785
chr88274913582749745E08242696
chr88274982582749873E08243386
chr88275155182751632E08245112
chr88275169382751743E08245254
chr88275176982751905E08245330
chr88275192082751978E08245481
chr88275205182752101E08245612
chr88275213682752286E08245697
chr88275242482752500E08245985
chr88275252382752586E08246084










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr88275290282753069E06746463
chr88275314082753307E06746701
chr88275349982753591E06747060
chr88275360282754599E06747163
chr88275349982753591E06847060
chr88275360282754599E06847163
chr88275461982755486E06848180
chr88275290282753069E06946463
chr88275314082753307E06946701
chr88275349982753591E06947060
chr88275360282754599E06947163
chr88275290282753069E07046463
chr88275314082753307E07046701
chr88275349982753591E07047060
chr88275360282754599E07047163
chr88275290282753069E07146463
chr88275314082753307E07146701
chr88275349982753591E07147060
chr88275360282754599E07147163
chr88275461982755486E07148180
chr88275290282753069E07246463
chr88275314082753307E07246701
chr88275349982753591E07247060
chr88275360282754599E07247163
chr88275290282753069E07346463
chr88275314082753307E07346701
chr88275349982753591E07347060
chr88275360282754599E07347163
chr88275461982755486E07348180
chr88275314082753307E07446701
chr88275349982753591E07447060
chr88275360282754599E07447163
chr88275461982755486E07448180
chr88275360282754599E08147163
chr88275290282753069E08246463
chr88275314082753307E08246701
chr88275349982753591E08247060
chr88275360282754599E08247163
chr88275461982755486E08248180