rs2400540

Homo sapiens
A>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0333 (9971/29910,GnomAD)
C=0344 (10019/29118,TOPMED)
C=0386 (1933/5008,1000G)
C=0332 (1280/3854,ALSPAC)
C=0320 (1188/3708,TWINSUK)
chr8:81851713 (GRCh38.p7) (8q21.13)
AD
GWASdb2
1   publication(s)
See rs on genome
89 Enhancers around
39 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.81851713A>C
GRCh37.p13 chr 8NC_000008.10:g.82763948A>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.664C=0.336
1000GenomesAmericanSub694A=0.610C=0.390
1000GenomesEast AsianSub1008A=0.403C=0.597
1000GenomesEuropeSub1006A=0.670C=0.330
1000GenomesGlobalStudy-wide5008A=0.614C=0.386
1000GenomesSouth AsianSub978A=0.710C=0.290
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.668C=0.332
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.655C=0.344
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.680C=0.320
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs24005403.51E-05alcohol consumption23743675

eQTL of rs2400540 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2400540 in Fetal Brain

Probe ID Position Gene beta p-value
cg17211192chr8:82754475SNX160.06514329975886591.7902e-27
cg27398817chr8:82754497SNX160.03860539417403211.4948e-15
cg23324259chr8:82754387SNX160.01760124910621795.6813e-14

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr88272692182727044E067-36904
chr88272708482727145E067-36803
chr88272739782727713E067-36235
chr88275141582751459E067-12489
chr88275155182751632E067-12316
chr88275169382751743E067-12205
chr88275176982751905E067-12043
chr88275192082751978E067-11970
chr88275205182752101E067-11847
chr88275213682752286E067-11662
chr88275242482752500E067-11448
chr88275252382752586E067-11362
chr88274913582749745E068-14203
chr88275040382750493E068-13455
chr88275055782750622E068-13326
chr88275073382750913E068-13035
chr88275118682751259E068-12689
chr88275141582751459E068-12489
chr88275155182751632E068-12316
chr88275169382751743E068-12205
chr88275242482752500E068-11448
chr88275252382752586E068-11362
chr88275264882752702E068-11246
chr88275205182752101E069-11847
chr88275213682752286E069-11662
chr88275242482752500E069-11448
chr88275252382752586E069-11362
chr88275264882752702E069-11246
chr88273635982736422E070-27526
chr88273760682737656E070-26292
chr88273770482737783E070-26165
chr88274913582749745E070-14203
chr88272692182727044E071-36904
chr88272739782727713E071-36235
chr88275040382750493E071-13455
chr88275055782750622E071-13326
chr88275073382750913E071-13035
chr88275176982751905E071-12043
chr88275192082751978E071-11970
chr88275205182752101E071-11847
chr88275213682752286E071-11662
chr88275242482752500E071-11448
chr88275252382752586E071-11362
chr88275264882752702E071-11246
chr88277068982771569E0716741
chr88278429982784817E07120351
chr88272629482726439E072-37509
chr88272692182727044E072-36904
chr88272708482727145E072-36803
chr88272739782727713E072-36235
chr88272739782727713E073-36235
chr88272692182727044E074-36904
chr88275040382750493E074-13455
chr88275055782750622E074-13326
chr88275073382750913E074-13035
chr88275118682751259E074-12689
chr88275141582751459E074-12489
chr88275155182751632E074-12316
chr88275169382751743E074-12205
chr88275176982751905E074-12043
chr88275192082751978E074-11970
chr88275205182752101E074-11847
chr88275213682752286E074-11662
chr88275242482752500E074-11448
chr88275252382752586E074-11362
chr88275264882752702E074-11246
chr88278429982784817E07420351
chr88274894182748991E081-14957
chr88275118682751259E081-12689
chr88275141582751459E081-12489
chr88275155182751632E081-12316
chr88275169382751743E081-12205
chr88275176982751905E081-12043
chr88275192082751978E081-11970
chr88275205182752101E081-11847
chr88275213682752286E081-11662
chr88275242482752500E081-11448
chr88275252382752586E081-11362
chr88275264882752702E081-11246
chr88274913582749745E082-14203
chr88274982582749873E082-14075
chr88275155182751632E082-12316
chr88275169382751743E082-12205
chr88275176982751905E082-12043
chr88275192082751978E082-11970
chr88275205182752101E082-11847
chr88275213682752286E082-11662
chr88275242482752500E082-11448
chr88275252382752586E082-11362










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr88275290282753069E067-10879
chr88275314082753307E067-10641
chr88275349982753591E067-10357
chr88275360282754599E067-9349
chr88275349982753591E068-10357
chr88275360282754599E068-9349
chr88275461982755486E068-8462
chr88275290282753069E069-10879
chr88275314082753307E069-10641
chr88275349982753591E069-10357
chr88275360282754599E069-9349
chr88275290282753069E070-10879
chr88275314082753307E070-10641
chr88275349982753591E070-10357
chr88275360282754599E070-9349
chr88275290282753069E071-10879
chr88275314082753307E071-10641
chr88275349982753591E071-10357
chr88275360282754599E071-9349
chr88275461982755486E071-8462
chr88275290282753069E072-10879
chr88275314082753307E072-10641
chr88275349982753591E072-10357
chr88275360282754599E072-9349
chr88275290282753069E073-10879
chr88275314082753307E073-10641
chr88275349982753591E073-10357
chr88275360282754599E073-9349
chr88275461982755486E073-8462
chr88275314082753307E074-10641
chr88275349982753591E074-10357
chr88275360282754599E074-9349
chr88275461982755486E074-8462
chr88275360282754599E081-9349
chr88275290282753069E082-10879
chr88275314082753307E082-10641
chr88275349982753591E082-10357
chr88275360282754599E082-9349
chr88275461982755486E082-8462