SNP Detail Info-rs2468406

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0143 (4279/29914,GnomAD)
A=0167 (4871/29118,TOPMED)
A=0169 (848/5008,1000G)
A=0112 (432/3854,ALSPAC)
A=0095 (354/3708,TWINSUK)

Position: chr12:68556891 (GRCh38.p7) (12q15)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 2 Enhancers around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 12	NC_000012.12:g.68556891G>A
GRCh37.p13 chr 12	NC_000012.11:g.68950671G>A

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.737	A=0.263
1000Genomes	American	Sub	694	G=0.880	A=0.120
1000Genomes	East Asian	Sub	1008	G=0.815	A=0.185
1000Genomes	Europe	Sub	1006	G=0.889	A=0.111
1000Genomes	Global	Study-wide	5008	G=0.831	A=0.169
1000Genomes	South Asian	Sub	978	G=0.880	A=0.120
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.888	A=0.112
The Genome Aggregation Database	African	Sub	8706	G=0.763	A=0.237
The Genome Aggregation Database	American	Sub	836	G=0.870	A=0.130
The Genome Aggregation Database	East Asian	Sub	1618	G=0.840	A=0.160
The Genome Aggregation Database	Europe	Sub	18452	G=0.901	A=0.098
The Genome Aggregation Database	Global	Study-wide	29914	G=0.857	A=0.143
The Genome Aggregation Database	Other	Sub	302	G=0.890	A=0.110
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.832	A=0.167
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.905	A=0.095

PMID	Title	Author	Journal
17158188	Novel genes identified in a high-density genome wide association study for nicotine dependence.	Bierut LJ	Hum Mol Genet

SNP ID	p-value	Traits	Study
rs2468406	0.000987	nicotine dependence	17158188

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr12	68933543	68933636	E068	-17035
chr12	68915049	68916110	E071	-34561

rs2468406