rs2477735

Organism: Homo sapiens

Alleles: T>C

Gene : Feature

ARHGEF10L : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

C=0078 (2362/29972,GnomAD)
C=0090 (2645/29118,TOPMED)
C=0066 (333/5008,1000G)
C=0077 (297/3854,ALSPAC)
C=0078 (288/3708,TWINSUK)

Position: chr1:17542684 (GRCh38.p7) (1p36.13)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 399 Enhancers around

Promoter: 19 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 1	NC_000001.11:g.17542684T>C
GRCh37.p13 chr 1	NC_000001.10:g.17869179T>C

Gene: ARHGEF10L, Rho guanine nucleotide exchange factor 10 like(plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
ARHGEF10L transcript variant 1	NM_018125.3:c.	N/A	Intron Variant
ARHGEF10L transcript variant 2	NM_001011722.2:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant 3	NM_001319837.1:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant 4	NM_001319838.1:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X2	XM_005245923.2:c.	N/A	Intron Variant
ARHGEF10L transcript variant X9	XM_005245925.2:c.	N/A	Intron Variant
ARHGEF10L transcript variant X1	XM_006710728.1:c.	N/A	Intron Variant
ARHGEF10L transcript variant X7	XM_006710729.1:c.	N/A	Intron Variant
ARHGEF10L transcript variant X6	XM_006710731.1:c.	N/A	Intron Variant
ARHGEF10L transcript variant X12	XM_017001617.1:c.	N/A	Intron Variant
ARHGEF10L transcript variant X12	XM_005245927.2:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X13	XM_005245929.2:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X8	XM_011541691.2:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X10	XM_011541692.2:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X11	XM_011541693.2:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X21	XM_011541695.2:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X23	XM_011541696.2:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X16	XM_017001618.1:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X17	XM_017001619.1:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X18	XM_017001620.1:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X26	XM_017001621.1:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X27	XM_017001622.1:c.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X14	XR_001737276.1:n.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X19	XR_001737277.1:n.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X10	XR_946686.2:n.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X20	XR_946688.2:n.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X21	XR_946689.2:n.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X22	XR_946690.2:n.	N/A	Genic Upstream Transcript Variant
ARHGEF10L transcript variant X24	XR_946691.2:n.	N/A	Genic Upstream Transcript Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	T=0.883	C=0.117
1000Genomes	American	Sub	694	T=0.950	C=0.050
1000Genomes	East Asian	Sub	1008	T=0.994	C=0.006
1000Genomes	Europe	Sub	1006	T=0.933	C=0.067
1000Genomes	Global	Study-wide	5008	T=0.934	C=0.066
1000Genomes	South Asian	Sub	978	T=0.930	C=0.070
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	T=0.923	C=0.077
The Genome Aggregation Database	African	Sub	8722	T=0.897	C=0.103
The Genome Aggregation Database	American	Sub	838	T=0.960	C=0.040
The Genome Aggregation Database	East Asian	Sub	1622	T=0.992	C=0.008
The Genome Aggregation Database	Europe	Sub	18488	T=0.924	C=0.076
The Genome Aggregation Database	Global	Study-wide	29972	T=0.921	C=0.078
The Genome Aggregation Database	Other	Sub	302	T=0.970	C=0.030
Trans-Omics for Precision Medicine	Global	Study-wide	29118	T=0.909	C=0.090
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	T=0.922	C=0.078

PMID	Title	Author	Journal
20201924	Genome-wide association study of alcohol dependence implicates a region on chromosome 11.	Edenberg HJ	Alcohol Clin Exp Res

P-Value

SNP ID	p-value	Traits	Study
rs2477735	0.00027	alcohol dependence	20201924

eQTL of rs2477735 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs2477735 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr1	17828779	17829278	E067	-39901
chr1	17829286	17829561	E067	-39618
chr1	17864060	17864129	E067	-5050
chr1	17864601	17865711	E067	-3468
chr1	17873894	17874069	E067	4715
chr1	17877217	17877839	E067	8038
chr1	17877892	17877956	E067	8713
chr1	17878031	17878131	E067	8852
chr1	17888138	17888493	E067	18959
chr1	17890554	17890642	E067	21375
chr1	17891005	17891146	E067	21826
chr1	17891274	17891388	E067	22095
chr1	17891406	17891589	E067	22227
chr1	17891699	17892037	E067	22520
chr1	17892086	17892255	E067	22907
chr1	17892303	17892587	E067	23124
chr1	17893021	17893284	E067	23842
chr1	17893538	17893619	E067	24359
chr1	17893762	17893836	E067	24583
chr1	17894145	17894467	E067	24966
chr1	17894638	17894698	E067	25459
chr1	17895170	17895335	E067	25991
chr1	17895451	17895614	E067	26272
chr1	17895659	17896724	E067	26480
chr1	17896758	17896982	E067	27579
chr1	17897104	17897231	E067	27925
chr1	17897687	17897766	E067	28508
chr1	17898892	17899011	E067	29713
chr1	17899034	17899159	E067	29855
chr1	17899163	17899424	E067	29984
chr1	17899458	17899582	E067	30279
chr1	17899641	17899737	E067	30462
chr1	17899877	17900574	E067	30698
chr1	17900761	17900811	E067	31582
chr1	17913688	17913795	E067	44509
chr1	17829286	17829561	E068	-39618
chr1	17858140	17858939	E068	-10240
chr1	17858942	17858991	E068	-10188
chr1	17860315	17860416	E068	-8763
chr1	17862183	17862377	E068	-6802
chr1	17864060	17864129	E068	-5050
chr1	17864601	17865711	E068	-3468
chr1	17871596	17872206	E068	2417
chr1	17873435	17873511	E068	4256
chr1	17873512	17873768	E068	4333
chr1	17873894	17874069	E068	4715
chr1	17877043	17877187	E068	7864
chr1	17877217	17877839	E068	8038
chr1	17877892	17877956	E068	8713
chr1	17878031	17878131	E068	8852
chr1	17878205	17878821	E068	9026
chr1	17888138	17888493	E068	18959
chr1	17889068	17889241	E068	19889
chr1	17889761	17889821	E068	20582
chr1	17890554	17890642	E068	21375
chr1	17891005	17891146	E068	21826
chr1	17891274	17891388	E068	22095
chr1	17891406	17891589	E068	22227
chr1	17891699	17892037	E068	22520
chr1	17892086	17892255	E068	22907
chr1	17892303	17892587	E068	23124
chr1	17893021	17893284	E068	23842
chr1	17893538	17893619	E068	24359
chr1	17894638	17894698	E068	25459
chr1	17895170	17895335	E068	25991
chr1	17895451	17895614	E068	26272
chr1	17895659	17896724	E068	26480
chr1	17896758	17896982	E068	27579
chr1	17897104	17897231	E068	27925
chr1	17897687	17897766	E068	28508
chr1	17898769	17898842	E068	29590
chr1	17898892	17899011	E068	29713
chr1	17899034	17899159	E068	29855
chr1	17899163	17899424	E068	29984
chr1	17899458	17899582	E068	30279
chr1	17899641	17899737	E068	30462
chr1	17899877	17900574	E068	30698
chr1	17900761	17900811	E068	31582
chr1	17901025	17901118	E068	31846
chr1	17901143	17901378	E068	31964
chr1	17901969	17902037	E068	32790
chr1	17913808	17915364	E068	44629
chr1	17828779	17829278	E069	-39901
chr1	17829286	17829561	E069	-39618
chr1	17853759	17853921	E069	-15258
chr1	17858140	17858939	E069	-10240
chr1	17858942	17858991	E069	-10188
chr1	17864601	17865711	E069	-3468
chr1	17871596	17872206	E069	2417
chr1	17873894	17874069	E069	4715
chr1	17874312	17874668	E069	5133
chr1	17877217	17877839	E069	8038
chr1	17877892	17877956	E069	8713
chr1	17878031	17878131	E069	8852
chr1	17878205	17878821	E069	9026
chr1	17887716	17888024	E069	18537
chr1	17888138	17888493	E069	18959
chr1	17889068	17889241	E069	19889
chr1	17890554	17890642	E069	21375
chr1	17891005	17891146	E069	21826
chr1	17891274	17891388	E069	22095
chr1	17891406	17891589	E069	22227
chr1	17891699	17892037	E069	22520
chr1	17892086	17892255	E069	22907
chr1	17892303	17892587	E069	23124
chr1	17893021	17893284	E069	23842
chr1	17895170	17895335	E069	25991
chr1	17895451	17895614	E069	26272
chr1	17895659	17896724	E069	26480
chr1	17896758	17896982	E069	27579
chr1	17897104	17897231	E069	27925
chr1	17898769	17898842	E069	29590
chr1	17898892	17899011	E069	29713
chr1	17899034	17899159	E069	29855
chr1	17899163	17899424	E069	29984
chr1	17899458	17899582	E069	30279
chr1	17899641	17899737	E069	30462
chr1	17899877	17900574	E069	30698
chr1	17900761	17900811	E069	31582
chr1	17901025	17901118	E069	31846
chr1	17901143	17901378	E069	31964
chr1	17828779	17829278	E070	-39901
chr1	17829286	17829561	E070	-39618
chr1	17858140	17858939	E070	-10240
chr1	17858942	17858991	E070	-10188
chr1	17862183	17862377	E070	-6802
chr1	17862586	17862699	E070	-6480
chr1	17863079	17863269	E070	-5910
chr1	17864060	17864129	E070	-5050
chr1	17871596	17872206	E070	2417
chr1	17872417	17872520	E070	3238
chr1	17872900	17873211	E070	3721
chr1	17873894	17874069	E070	4715
chr1	17874312	17874668	E070	5133
chr1	17874820	17875107	E070	5641
chr1	17877217	17877839	E070	8038
chr1	17877892	17877956	E070	8713
chr1	17878031	17878131	E070	8852
chr1	17878205	17878821	E070	9026
chr1	17887716	17888024	E070	18537
chr1	17890554	17890642	E070	21375
chr1	17891005	17891146	E070	21826
chr1	17891274	17891388	E070	22095
chr1	17891406	17891589	E070	22227
chr1	17893021	17893284	E070	23842
chr1	17893538	17893619	E070	24359
chr1	17895170	17895335	E070	25991
chr1	17895451	17895614	E070	26272
chr1	17895659	17896724	E070	26480
chr1	17897687	17897766	E070	28508
chr1	17898769	17898842	E070	29590
chr1	17898892	17899011	E070	29713
chr1	17899034	17899159	E070	29855
chr1	17899163	17899424	E070	29984
chr1	17899458	17899582	E070	30279
chr1	17899641	17899737	E070	30462
chr1	17899877	17900574	E070	30698
chr1	17900761	17900811	E070	31582
chr1	17901025	17901118	E070	31846
chr1	17901143	17901378	E070	31964
chr1	17901969	17902037	E070	32790
chr1	17902156	17902615	E070	32977
chr1	17902621	17902669	E070	33442
chr1	17902716	17902897	E070	33537
chr1	17902915	17903042	E070	33736
chr1	17913688	17913795	E070	44509
chr1	17828779	17829278	E071	-39901
chr1	17829286	17829561	E071	-39618
chr1	17829712	17829992	E071	-39187
chr1	17853759	17853921	E071	-15258
chr1	17854070	17854336	E071	-14843
chr1	17858140	17858939	E071	-10240
chr1	17858942	17858991	E071	-10188
chr1	17864601	17865711	E071	-3468
chr1	17869207	17869548	E071	28
chr1	17869594	17869644	E071	415
chr1	17871596	17872206	E071	2417
chr1	17872417	17872520	E071	3238
chr1	17872900	17873211	E071	3721
chr1	17873435	17873511	E071	4256
chr1	17873512	17873768	E071	4333
chr1	17873894	17874069	E071	4715
chr1	17877217	17877839	E071	8038
chr1	17877892	17877956	E071	8713
chr1	17878031	17878131	E071	8852
chr1	17878205	17878821	E071	9026
chr1	17887495	17887549	E071	18316
chr1	17888138	17888493	E071	18959
chr1	17889068	17889241	E071	19889
chr1	17889761	17889821	E071	20582
chr1	17890554	17890642	E071	21375
chr1	17891005	17891146	E071	21826
chr1	17891274	17891388	E071	22095
chr1	17891406	17891589	E071	22227
chr1	17891699	17892037	E071	22520
chr1	17892086	17892255	E071	22907
chr1	17892303	17892587	E071	23124
chr1	17893021	17893284	E071	23842
chr1	17893538	17893619	E071	24359
chr1	17894145	17894467	E071	24966
chr1	17894638	17894698	E071	25459
chr1	17895170	17895335	E071	25991
chr1	17895451	17895614	E071	26272
chr1	17895659	17896724	E071	26480
chr1	17896758	17896982	E071	27579
chr1	17897104	17897231	E071	27925
chr1	17897687	17897766	E071	28508
chr1	17898769	17898842	E071	29590
chr1	17898892	17899011	E071	29713
chr1	17899034	17899159	E071	29855
chr1	17899163	17899424	E071	29984
chr1	17899458	17899582	E071	30279
chr1	17899641	17899737	E071	30462
chr1	17899877	17900574	E071	30698
chr1	17900761	17900811	E071	31582
chr1	17901025	17901118	E071	31846
chr1	17901143	17901378	E071	31964
chr1	17901969	17902037	E071	32790
chr1	17902156	17902615	E071	32977
chr1	17913808	17915364	E071	44629
chr1	17828779	17829278	E072	-39901
chr1	17829286	17829561	E072	-39618
chr1	17858140	17858939	E072	-10240
chr1	17871596	17872206	E072	2417
chr1	17877217	17877839	E072	8038
chr1	17877892	17877956	E072	8713
chr1	17878031	17878131	E072	8852
chr1	17887495	17887549	E072	18316
chr1	17887716	17888024	E072	18537
chr1	17888138	17888493	E072	18959
chr1	17890554	17890642	E072	21375
chr1	17891005	17891146	E072	21826
chr1	17891274	17891388	E072	22095
chr1	17891406	17891589	E072	22227
chr1	17891699	17892037	E072	22520
chr1	17892086	17892255	E072	22907
chr1	17892303	17892587	E072	23124
chr1	17893021	17893284	E072	23842
chr1	17895170	17895335	E072	25991
chr1	17895451	17895614	E072	26272
chr1	17895659	17896724	E072	26480
chr1	17896758	17896982	E072	27579
chr1	17897104	17897231	E072	27925
chr1	17897687	17897766	E072	28508
chr1	17899163	17899424	E072	29984
chr1	17899458	17899582	E072	30279
chr1	17899641	17899737	E072	30462
chr1	17899877	17900574	E072	30698
chr1	17900761	17900811	E072	31582
chr1	17901025	17901118	E072	31846
chr1	17901143	17901378	E072	31964
chr1	17913808	17915364	E072	44629
chr1	17858140	17858939	E073	-10240
chr1	17858942	17858991	E073	-10188
chr1	17862183	17862377	E073	-6802
chr1	17862586	17862699	E073	-6480
chr1	17864601	17865711	E073	-3468
chr1	17871596	17872206	E073	2417
chr1	17872417	17872520	E073	3238
chr1	17872900	17873211	E073	3721
chr1	17873435	17873511	E073	4256
chr1	17873512	17873768	E073	4333
chr1	17873894	17874069	E073	4715
chr1	17874312	17874668	E073	5133
chr1	17877043	17877187	E073	7864
chr1	17877217	17877839	E073	8038
chr1	17877892	17877956	E073	8713
chr1	17878031	17878131	E073	8852
chr1	17878205	17878821	E073	9026
chr1	17887716	17888024	E073	18537
chr1	17888138	17888493	E073	18959
chr1	17889068	17889241	E073	19889
chr1	17890554	17890642	E073	21375
chr1	17891005	17891146	E073	21826
chr1	17891274	17891388	E073	22095
chr1	17891406	17891589	E073	22227
chr1	17891699	17892037	E073	22520
chr1	17892086	17892255	E073	22907
chr1	17892303	17892587	E073	23124
chr1	17893021	17893284	E073	23842
chr1	17893538	17893619	E073	24359
chr1	17894638	17894698	E073	25459
chr1	17895170	17895335	E073	25991
chr1	17895451	17895614	E073	26272
chr1	17895659	17896724	E073	26480
chr1	17896758	17896982	E073	27579
chr1	17897104	17897231	E073	27925
chr1	17898892	17899011	E073	29713
chr1	17899034	17899159	E073	29855
chr1	17899163	17899424	E073	29984
chr1	17899458	17899582	E073	30279
chr1	17899641	17899737	E073	30462
chr1	17899877	17900574	E073	30698
chr1	17900761	17900811	E073	31582
chr1	17901025	17901118	E073	31846
chr1	17901143	17901378	E073	31964
chr1	17901969	17902037	E073	32790
chr1	17828779	17829278	E074	-39901
chr1	17829286	17829561	E074	-39618
chr1	17853429	17853489	E074	-15690
chr1	17853586	17853636	E074	-15543
chr1	17853653	17853713	E074	-15466
chr1	17853759	17853921	E074	-15258
chr1	17854070	17854336	E074	-14843
chr1	17858140	17858939	E074	-10240
chr1	17858942	17858991	E074	-10188
chr1	17864601	17865711	E074	-3468
chr1	17872900	17873211	E074	3721
chr1	17873435	17873511	E074	4256
chr1	17873512	17873768	E074	4333
chr1	17873894	17874069	E074	4715
chr1	17877043	17877187	E074	7864
chr1	17877217	17877839	E074	8038
chr1	17877892	17877956	E074	8713
chr1	17878031	17878131	E074	8852
chr1	17878205	17878821	E074	9026
chr1	17887495	17887549	E074	18316
chr1	17887716	17888024	E074	18537
chr1	17888138	17888493	E074	18959
chr1	17889068	17889241	E074	19889
chr1	17889761	17889821	E074	20582
chr1	17890554	17890642	E074	21375
chr1	17891005	17891146	E074	21826
chr1	17891274	17891388	E074	22095
chr1	17891406	17891589	E074	22227
chr1	17891699	17892037	E074	22520
chr1	17892086	17892255	E074	22907
chr1	17892303	17892587	E074	23124
chr1	17893021	17893284	E074	23842
chr1	17894145	17894467	E074	24966
chr1	17894638	17894698	E074	25459
chr1	17895170	17895335	E074	25991
chr1	17895451	17895614	E074	26272
chr1	17895659	17896724	E074	26480
chr1	17896758	17896982	E074	27579
chr1	17897104	17897231	E074	27925
chr1	17897687	17897766	E074	28508
chr1	17898769	17898842	E074	29590
chr1	17898892	17899011	E074	29713
chr1	17899034	17899159	E074	29855
chr1	17899163	17899424	E074	29984
chr1	17899458	17899582	E074	30279
chr1	17899641	17899737	E074	30462
chr1	17899877	17900574	E074	30698
chr1	17900761	17900811	E074	31582
chr1	17901025	17901118	E074	31846
chr1	17901143	17901378	E074	31964
chr1	17901969	17902037	E074	32790
chr1	17902156	17902615	E074	32977
chr1	17902621	17902669	E074	33442
chr1	17902716	17902897	E074	33537
chr1	17902915	17903042	E074	33736
chr1	17903116	17903171	E074	33937
chr1	17912644	17913675	E074	43465
chr1	17913688	17913795	E074	44509
chr1	17913808	17915364	E074	44629
chr1	17864601	17865711	E081	-3468
chr1	17871596	17872206	E081	2417
chr1	17872417	17872520	E081	3238
chr1	17872900	17873211	E081	3721
chr1	17873435	17873511	E081	4256
chr1	17873512	17873768	E081	4333
chr1	17873894	17874069	E081	4715
chr1	17877217	17877839	E081	8038
chr1	17877892	17877956	E081	8713
chr1	17887716	17888024	E081	18537
chr1	17890554	17890642	E081	21375
chr1	17891005	17891146	E081	21826
chr1	17891274	17891388	E081	22095
chr1	17891406	17891589	E081	22227
chr1	17891699	17892037	E081	22520
chr1	17892086	17892255	E081	22907
chr1	17892303	17892587	E081	23124
chr1	17898769	17898842	E081	29590
chr1	17898892	17899011	E081	29713
chr1	17899034	17899159	E081	29855
chr1	17899163	17899424	E081	29984
chr1	17899458	17899582	E081	30279
chr1	17899641	17899737	E081	30462
chr1	17899877	17900574	E081	30698
chr1	17900761	17900811	E081	31582
chr1	17871596	17872206	E082	2417
chr1	17872417	17872520	E082	3238
chr1	17872900	17873211	E082	3721
chr1	17873435	17873511	E082	4256
chr1	17873512	17873768	E082	4333
chr1	17887716	17888024	E082	18537
chr1	17888138	17888493	E082	18959
chr1	17891406	17891589	E082	22227
chr1	17891699	17892037	E082	22520
chr1	17892303	17892587	E082	23124
chr1	17893021	17893284	E082	23842
chr1	17893538	17893619	E082	24359
chr1	17893762	17893836	E082	24583
chr1	17899163	17899424	E082	29984
chr1	17899458	17899582	E082	30279
chr1	17899641	17899737	E082	30462
chr1	17899877	17900574	E082	30698
chr1	17912234	17912360	E082	43055

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr1	17866098	17866238	E067	-2941
chr1	17866243	17867757	E067	-1422
chr1	17866098	17866238	E068	-2941
chr1	17866243	17867757	E068	-1422
chr1	17866098	17866238	E069	-2941
chr1	17866243	17867757	E069	-1422
chr1	17866098	17866238	E070	-2941
chr1	17866243	17867757	E070	-1422
chr1	17866098	17866238	E071	-2941
chr1	17866243	17867757	E071	-1422
chr1	17866098	17866238	E072	-2941
chr1	17866243	17867757	E072	-1422
chr1	17866098	17866238	E073	-2941
chr1	17866243	17867757	E073	-1422
chr1	17866098	17866238	E074	-2941
chr1	17866243	17867757	E074	-1422
chr1	17866243	17867757	E081	-1422
chr1	17866098	17866238	E082	-2941
chr1	17866243	17867757	E082	-1422