rs2525994

Homo sapiens
C>A
TRIM25 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0228 (6818/29890,GnomAD)
C==0219 (6400/29118,TOPMED)
C==0220 (1104/5008,1000G)
C==0261 (1005/3854,ALSPAC)
C==0263 (975/3708,TWINSUK)
chr17:56899561 (GRCh38.p7) (17q22)
AD
GWASdb2
1   publication(s)
See rs on genome
5 Enhancers around
8 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 17NC_000017.11:g.56899561C>A
GRCh37.p13 chr 17NC_000017.10:g.54976922C>A

Gene: TRIM25, tripartite motif containing 25(minus strand)

Molecule type Change Amino acid[Codon] SO Term
TRIM25 transcriptNM_005082.4:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.140A=0.860
1000GenomesAmericanSub694C=0.290A=0.710
1000GenomesEast AsianSub1008C=0.191A=0.809
1000GenomesEuropeSub1006C=0.247A=0.753
1000GenomesGlobalStudy-wide5008C=0.220A=0.780
1000GenomesSouth AsianSub978C=0.280A=0.720
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.261A=0.739
The Genome Aggregation DatabaseAfricanSub8684C=0.155A=0.845
The Genome Aggregation DatabaseAmericanSub838C=0.260A=0.740
The Genome Aggregation DatabaseEast AsianSub1616C=0.149A=0.851
The Genome Aggregation DatabaseEuropeSub18452C=0.269A=0.730
The Genome Aggregation DatabaseGlobalStudy-wide29890C=0.228A=0.771
The Genome Aggregation DatabaseOtherSub300C=0.150A=0.850
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.219A=0.780
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.263A=0.737
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs25259940.000772alcohol dependence21314694

eQTL of rs2525994 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2525994 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr175498808754988374E06711165
chr175498808754988374E06811165
chr175496217354962407E070-14515
chr175496253854962606E070-14316
chr175498808754988374E07111165




Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr175499038654993682E06713464
chr175499038654993682E06813464
chr175499038654993682E06913464
chr175499038654993682E07113464
chr175499038654993682E07213464
chr175499038654993682E07313464
chr175499038654993682E07413464
chr175499038654993682E08213464