rs2542435

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0113 (3406/29944,GnomAD)
A=0124 (3614/29118,TOPMED)
A=0074 (369/5008,1000G)
A=0119 (457/3854,ALSPAC)
A=0117 (433/3708,TWINSUK)
chr8:139591259 (GRCh38.p7) (8q24.3)
AD
GWASdb2
1   publication(s)
See rs on genome
58 Enhancers around
6 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.139591259G>A
GRCh37.p13 chr 8NC_000008.10:g.140603502G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.877A=0.123
1000GenomesAmericanSub694G=0.910A=0.090
1000GenomesEast AsianSub1008G=1.000A=0.000
1000GenomesEuropeSub1006G=0.875A=0.125
1000GenomesGlobalStudy-wide5008G=0.926A=0.074
1000GenomesSouth AsianSub978G=0.980A=0.020
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.881A=0.119
The Genome Aggregation DatabaseAfricanSub8718G=0.862A=0.138
The Genome Aggregation DatabaseAmericanSub834G=0.910A=0.090
The Genome Aggregation DatabaseEast AsianSub1620G=0.999A=0.001
The Genome Aggregation DatabaseEuropeSub18470G=0.886A=0.113
The Genome Aggregation DatabaseGlobalStudy-wide29944G=0.886A=0.113
The Genome Aggregation DatabaseOtherSub302G=0.890A=0.110
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.875A=0.124
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.883A=0.117
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs25424350.000299alcohol dependence21314694

eQTL of rs2542435 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2542435 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr8140642890140643799E06739388
chr8140631441140631505E06827939
chr8140631646140631700E06828144
chr8140642890140643799E06839388
chr8140642890140643799E06939388
chr8140616499140616549E07012997
chr8140619166140619312E07015664
chr8140620189140620239E07016687
chr8140642754140642878E07039252
chr8140642890140643799E07039388
chr8140631441140631505E07127939
chr8140642754140642878E07139252
chr8140642890140643799E07139388
chr8140642890140643799E07239388
chr8140644132140644212E07240630
chr8140644217140644328E07240715
chr8140645664140645771E07242162
chr8140645804140645875E07242302
chr8140645887140645969E07242385
chr8140646139140646189E07242637
chr8140613761140613811E08110259
chr8140614042140614092E08110540
chr8140614364140614497E08110862
chr8140631441140631505E08127939
chr8140631646140631700E08128144
chr8140631926140632021E08128424
chr8140632239140632289E08128737
chr8140636023140636098E08132521
chr8140636248140636374E08132746
chr8140636425140636475E08132923
chr8140636530140636580E08133028
chr8140639108140639205E08135606
chr8140639647140640352E08136145
chr8140641115140641155E08137613
chr8140641358140641627E08137856
chr8140641701140641797E08138199
chr8140642079140642155E08138577
chr8140642512140642562E08139010
chr8140642754140642878E08139252
chr8140642890140643799E08139388
chr8140594944140594994E082-8508
chr8140595005140595074E082-8428
chr8140595155140595322E082-8180
chr8140595532140595606E082-7896
chr8140616347140616461E08212845
chr8140616499140616549E08212997
chr8140616552140616607E08213050
chr8140616954140617047E08213452
chr8140631441140631505E08227939
chr8140631646140631700E08228144
chr8140631926140632021E08228424
chr8140632239140632289E08228737
chr8140639647140640352E08236145
chr8140642754140642878E08239252
chr8140642890140643799E08239388
chr8140644132140644212E08240630
chr8140644217140644328E08240715
chr8140644715140644820E08241213








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr8140594281140594610E068-8892
chr8140594281140594610E069-8892
chr8140594281140594610E071-8892
chr8140594281140594610E072-8892
chr8140594281140594610E073-8892
chr8140594281140594610E074-8892