rs2567261

Homo sapiens
T>C
ARHGAP28 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0144 (4330/29932,GnomAD)
T==0170 (4976/29118,TOPMED)
T==0228 (1140/5008,1000G)
T==0084 (324/3854,ALSPAC)
T==0094 (349/3708,TWINSUK)
chr18:6868926 (GRCh38.p7) (18p11.31)
AD
GWASdb2
2   publication(s)
See rs on genome
18 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.6868926T>C
GRCh37.p13 chr 18NC_000018.9:g.6868925T>C

Gene: ARHGAP28, Rho GTPase activating protein 28(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ARHGAP28 transcriptNM_001010000.2:c.N/AIntron Variant
ARHGAP28 transcript variant X1XM_005258144.1:c.N/AIntron Variant
ARHGAP28 transcript variant X2XM_005258145.1:c.N/AIntron Variant
ARHGAP28 transcript variant X3XM_005258146.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.235C=0.765
1000GenomesAmericanSub694T=0.160C=0.840
1000GenomesEast AsianSub1008T=0.292C=0.708
1000GenomesEuropeSub1006T=0.096C=0.904
1000GenomesGlobalStudy-wide5008T=0.228C=0.772
1000GenomesSouth AsianSub978T=0.340C=0.660
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.084C=0.916
The Genome Aggregation DatabaseAfricanSub8704T=0.227C=0.773
The Genome Aggregation DatabaseAmericanSub834T=0.150C=0.850
The Genome Aggregation DatabaseEast AsianSub1616T=0.284C=0.716
The Genome Aggregation DatabaseEuropeSub18476T=0.093C=0.906
The Genome Aggregation DatabaseGlobalStudy-wide29932T=0.144C=0.855
The Genome Aggregation DatabaseOtherSub302T=0.110C=0.890
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.170C=0.829
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.094C=0.906
PMID Title Author Journal
24832863Association of substance dependence phenotypes in the COGA sample.Wetherill LAddict Biol
23089632A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.Wang JCMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs25672611.21E-05alcohol dependence23089632

eQTL of rs2567261 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs2567261 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1868661086866148E070-2777
chr1868664096866630E070-2295
chr1868666416866796E070-2129
chr1868669396867019E070-1906
chr1868697276869908E070802
chr1868700746870209E0701149
chr1868786046879821E0709679
chr1868810076881890E07012082
chr1868734836873879E0814558
chr1868739026874052E0814977
chr1868784846878587E0819559
chr1868786046879821E0819679
chr1868798976880300E08110972
chr1868803536880907E08111428
chr1868867086886777E08117783
chr1868867986887407E08117873
chr1868786046879821E0829679
chr1868798976880300E08210972